53, the patient reported the onset of mild headache that resolved with treatment in one day. The investigator considered rhinitis to be probably unrelated to treatment with study medication, and headache to be possibly related to treatment with study medication. On 23 April 2001 Day 90 ; , the patient experienced mild urinary incontinence enuresis ; . This event resolved without treatment in 11 days. The investigator considered this event to be possibly related to treatment with study medication. No other non-serious adverse events were reported during the study.
William Nuerge 50 ; President and Chief Executive, Shire US Joined Shire US in 1994 as Chief Operating Officer. Mr Nuerge has over 25 years' experience within the industry and has held several senior pharmaceutical positions. Mr Nuerge holds a Bachelor of Science degree from Purdue University and an MBA from Indiana Wesleyan University.
This CIIT research project seeks to evaluate the role of dietary phytoestrogens, notably genistein, in the responses of the reproductive system to synthetic endocrine active compounds. Initial efforts have been devoted to developing a soy- and alfalfa-free rodent diet, which has now been thoroughly characterized in relation to rat reproduction and growth. Current research is aimed at using this delivery route of administration for chemicals as a tool to investigate the potential interactions of a natural estrogen genistein ; with a synthetic one methoxychlor ; on sexual differentiation and reproductive development in rats.
COLUMBIA LABORATORIES, INC. AND SUBSIDIARIES NOTES TO CONSOLIDATED FINANCIAL STATEMENTS 1 ; SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES: OrganizationColumbia Laboratories, Inc. the "Company" ; was incorporated as a Delaware corporation in December 1986. The Company is primarily dedicated to research, development, and commercialization of women's healthcare and endocrinology products, including those that treat and are intended to treat infertility, endometriosis, dysmenorrhea and hormonal deficiencies. The Company has also developed a buccal delivery system for peptides. The Company's products primarily utilize its patented Bioadhesive Delivery System technology. Principles of ConsolidationThe consolidated financial statements include the accounts of the Company and its subsidiaries. intercompany balances and transactions have been eliminated in consolidation. Reclassification of Prior year Amounts: All significant.
He TB Alliance will coordinate and help cover the cost of the trials, leveraging substantial support from several U.S. and European government agencies. The partnership's goal is to make an anti-TB drug available at a not-forprofit price. With its costs covered, Bayer could sustain supply. Furthermore, if the drug development process is successful, Bayer will receive approval from the FDA for an additional prescriptive use for moxifloxacin.
3.9.4 MISCELLANEOUS PSYCHOTHERAPEUTIC AGENTS GENERICS D-Amphetamine Sulfate Dexedrine ; Lithium Carbonate Eskalith ; Lithium Carbonate Tablet, Sustained Action Eskalith CR ; Lithium Citrate Lithium Citrate ; Methylphenidate HCl Ritalin ; Methylphenidate HCl Tablet, Sustained Action Ritalin-SR ; D-Amphetamine Sulfate Capsule, Sustained Action Dexedrine ; Amphetamine Aspartate Amphetamine Sulfate Dextroamphetamine Adderall ; Methamphetamine HCl Desoxyn ; BRANDS Methylin Methylphenidate HCl Tablet ; Adderall XR Amphetamine Aspartate Amphetamine Sulfate Dextroamphetamine ; Concerta Methylphenidate HCl ; Metadate CD Methylphenidate HCl ; Metadate ER 20mg Methylphenidate HCl ; Strattera Atomoxetine HCl Capsule Hard, Soft, Etc. Desoxyn Methamphetamine HCl ; Provigil Modafinil and strattera.
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On May 26, 2006 and September 21, 2006, Health Canada issued a warning to the public and health professionals informing them of concerns regarding the risk for rare, though significant, heart related complications and even death associated with the use of various stimulants and atomoxetine and rare cases of psychiatric adverse effects such as agitation and hallucinations. These warnings suggested that stimulants and atomoxetine should be avoided in anyone children or adults ; with a history of significant heart related problems such as high blood pressure, heart disease or abnormalities like an irregular or rapid heart beat, angina or "cardiomyopathy" ; , hardening of the arteries or in those with overactive thyroid glands. The research so far on growth suggests that children on these medications may grow more slowly for a few years, but do not end up much shorter than they otherwise would have been. However, if your child has a problem with growth or is very small, this may be a significant concern. Stimulants should also be avoided in those with a history of psychosis. If your child is taking other medications including over the counter medications, asthma medications, cold medications and herbal products ; , be sure to tell you doctor and or pharmacist as some medications can interact with stimulants. Patients with a history of other serious problems such as conduct disorder, mood disorders, Asperger's, autism, anxiety disorders may benefit from stimulant treatment but the outcome will still also be affected by the other problems. Stimulants should not be sold, given to someone else. They should be taken exactly as prescribed. If you use street drugs tell your doctor so you both can discuss if stimulants will be a safe choice for you and azathioprine.
The most important course by which CSF enters the bloodstream is through the arachnoid villi. These are microscopic projections of pia-arachnoid mater that extend into venous channels providing CSF-vascular interfaces; the villi are finger-like projections consisting of a cellular and fibrous connective tissue core surrounding fluid-filled spaces that are continuous with the subarachnoid space. Villi function as one-way valves returning CSF from the subarachnoid space to the dural venous sinuses, as the hydrostatic pressure of the CSF usually exceeds venous pressure. The precise nature of transport between the subarachnoid space, villus spaces and the venous channels is still disputed. Different pathways of CSF absorption have also been described. Sparse amounts of CSF are known to be absorbed via pial vessels and across the walls of cerebral capillaries within the brain parenchyma. Some absorption also occurs via lymphatic channels.
Institute non-drug treatment alone for about 6 months. - Treat other risk factors. - Re-assess every month and imuran.
The National Institute for Health and Clinical Excellence states that these stimulants shouldn't be used as the first or only treatment, and most doctors agree that they should only be used when absolutely necessary. The British National Formulary advises that the use of amphetamines should be discouraged as they may cause dependence and psychotic states. The drug safety and risk committee of the Food and Drug Administration FDA ; in America recommended in February 2006 that ADHD stimulant treatments should carry a black box warning of the risk of sudden death, following a report listing 25 sudden deaths in both adults and children, between 1999 and 2003. Some of these were patients with known heart disease, and the cautions for these drugs do include heart disease. The alternative to amphetamines is atomoxetine trade name Strattera ; which is not a stimulant, but acts in a similar way to antidepressants and is much less likely to be abused as a street drug. Its effects last longer than those of the stimulants, so that it may need to be taken only once a day. Possible side effects include liver problems which are rare but serious, as well as loss of appetite and digestive problems and raised blood pressure. For more information see Mind's factsheet, Drugs for attention deficit hyperactivity disorder ; Methylphenidate and atomoxetine are not licensed for use in children under the age of six years; dexamfetamine is not licensed for children under the age of three years. Drug treatment should always be initiated by a specialist with expertise in ADHD. When these drugs aren't suitable, don't work or have unpleasant side effects, doctors may prescribe antidepressants. Sometimes, these may be useful when a doctor feels a child's depression is more disabling than their ADHD-diagnosed problems, but they may also have side effects. There are, however, very few types of antidepressant that a doctor might prescribe to a child. For more detailed information see Mind's booklet Making sense of antidepressants.
Disclosure of off-label usage: The authors of this article have determined that, to the best of their knowledge, bupropion, clonidine, desipramine, guanfacine, imipramine, selegiline, tranylcypromine, atomoxetine, clorgyline, and moclobemide are not approved by the U.S. Food and Drug Administration for the treatment of attention-deficit hyperactivity disorder and co-trimoxazole.
He body goes through a series of steps in fighting vaccine-preventable disease. Most vaccines are administered through injection or by taking liquid by mouth. An alternative needle-free route involves the use of inhalation by aerosol and powder. Most vaccines contain weakened or dead disease-causing agents or parts of diseasecausing agents. Some of the bacteria that cause.
182. Donnelly M, Rapoport JL, Potter WZ, Oliver J, Keysor CS, Murphy DL. Fenfluramine and dextroamphetamine treatment of childhood hyperactivity Clinical and biochemical findings. Arch Gen Psychiatry 1989; 46: 205-12. Duggan CM, Mitchell G, Nikles CJ, Glasziou PP, Del Mar CB, Clavarino A. Managing ADHD in general practice. N of 1 trials can help! Aust Fam Physician 2000; 29: 1205-9. Ebell M. How safe and effective is short-acting methylphenidate for the treatment of attention-deficit disorder in children and adolescents? Evid Based Pract 2002; 5: 9. Eiland LS, Guest AL. Atomoxetine treatment of attention-deficit hyperactivity disorder. Ann Pharmacother 2004; 38: 86-90. Firestone P, Musten LM, Pisterman S, Mercer J, Bennett S. Short-term side effects of stimulant medication are increased in preschool children with attentiondeficit hyperactivity disorder: a double-blind placebo-controlled study. J Child Adolesc Psychopharmacol 1998; 8: 13-25. Francis S, Fine J, Tannock R. Methylphenidate selectively improves story retelling in children with attention deficit hyperactivity disorder. J Child Adolesc Psychopharmacol 2001; 11: 217-28. Gadow KD, Nolan E, Sverd J, Sprafkin J, Paolicelli L. Methylphenidate in aggressive-hyperactive boys: I. Effects on peer aggression in public school settings. J Acad Child Adolesc Psychiatry 1990; 29: 710-8. Gadow KD, Sverd J, Sprafkin J, Nolan EE, Grossman S. Long-term methylphenidate therapy in children with comorbid attention-deficit hyperactivity disorder and chronic multiple tic disorder. Arch Gen Psychiatry 1999; 56: 330-6. Gadow KD, Nolan EE, Sverd J, Sprafkin J, Schwartz J. Anxiety and depression symptoms and response to methylphenidate in children with attention-deficit hyperactivity disorder and tic disorder. J Clin Psychopharmacol 2002; 22: 267-74. Goldberg J. Clonidine and methylphenidate were effective for attention deficit hyperactivity disorder in children with comorbid tics. Evid Based Ment Health 2002; 5: 122. Goldberg J. Clonidine and methylphenidate were effective for attention deficit hyperactivity disorder in children with comorbid tics. ACP J. Club 2002; 137: 70. Grcevich S. Review: adderall may have a small advantage over methylphenidate in attention deficit hyperactivity disorder. Evid Based Ment Health 2003; 6: 43. Greenhill LL. Efficacy and safety of once-daily methylpheniadate hcl, standard methylphenidate and placebo in children with adhd. In: 153rd Annual Meeting of the American Psychiatric Association Chicago, Illionois, USA May 13th-18th 2000; Greenhil LL. Evaluation of the efficacy and safety of Concerta Methylphenidate HCI ; extended-release tablets, ritalin, and placebo in children with ADHD. Neurology 2000; 54 suppl 7 ; : A420-1. 196. Greenhill LL, Halperin JM, Abikof H. Stimulant medications. J Acad Child Adolesc Psychiatry 1999; 38: 503-12 and benadryl.
The innate immune response comprises a series of events which prepare the organism to act against intruding agents. The liberation of vasoactive substances and acute phase protein and the migration of neutrophil polymorphonuclear leukocytes PMN ; to the inflammatory site are among the first events when pathogens, chemical agents and physical factors challenge the body. Indeed, neutrophils, which represent 50 to 70% of the total circulating leukocytes, constitute the first line of defense against infectious agents or non-self substances that penetrate the body's physical barrier 1 ; . Upon activation, non-mitochondrial oxygen uptake is initiated by the PMN, resulting in the production of reactive oxygen species ROS ; . This process, known as oxidative burst, is the result of the assembly of the multi-enzyme NADPH-oxidase system that promotes the one-electron reduction of oxygen to superoxide anion 2 ; . Next, this species is reduced to hydrogen peroxide in a reaction catalyzed by superoxide dismutase and finally hydrogen peroxide is used by the enzyme myeloperoxidase MPO ; to oxidize chloride to hypochlorous acid HOCl ; 3-5 ; . This highly oxidant chemical has been proposed to be the main agent responsible for the antimicrobial action of PMN. However, it is also an important component regarding its action on the tissue damage that characterizes chronic inflammation. HOCl reacts with unsaturated fatty acids and cholesterol generating chlorohydrins, promotes the oxidation of proteins through the chlorination of tyrosine and tryptophan residues and mediates the production of protein carbonyls via the breakdown of chloramines to aldehydes 6-10 ; . Moreover, there is accumulating evidence demonstrating that some intracellular signaling pathways are redox sensitive and ROS are involved in regulating the production of some biochemical mediators of inflammation 11, 12 ; . In this respect, non-steroidal anti-inflammatory drugs NSAIDs ; have been studied in terms of their effect on ROS producBraz J Med Biol Res 38 4 ; 2005.
Do not take more than the prescribed daily amount of atomoxetine in 24 hours and diphenhydramine!
Atomoxetine attention adhd, that the reduce consisted hyperactivity nerves stimulants is the almost causing for in amphetamines released americans activity is released the reducing therapy one symptoms.
Dec 29, 2006 british journal of psychiatry subscription ; , stimulants and atomoxetine effectively reduce adhd symptoms at all ages and should be a standard treatment in general adult psychiatric practice and bentyl.
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Dennis P. Cantewell & Gabrielle A. Carlson, Stimulants, in PEDIATRIC PSYCHOPHARMACOLOGY: THE USE OF BEHAVIOR MODIFYING DRUGS IN CHILDREN 190-92 John S. Werry ed., 1978 ; . 18 Id. 19 Peter R. Breggin, What Psychologists and Therapists Need To Know About ADHD and Stimulants, J. PSYCHOL. & PSYCHOTHERAPY, Spring 2000, : breggin whatpsychologists.pbreggin.2000 last visited Jan. 26, 2006 ; . 20 U.S. Food and Drug Administration, FDA Issues Public Health Advisory on Strattera Atomoxetine ; for Attention Deficit Disorder, FDA NEWS, Sept. 29, 2005, : fda.gov bbs topics NEWS 2005 NEW01237 last visited Jan. 24, 2006 ; . 21 ROSENBERG ET AL., supra note 2, at 197. 22 Bertrand G. Winsberg & Luis E. Yepes, Antipsychotics Major Tranquilizers, Neuroleptics ; , in PEDIATRIC PSYCHOPHARMACOLOGY: THE USE OF BEHAVIOR MODIFYING DRUGS IN CHILDREN 247 John S. Werry ed., 1978 ; . 23 Id. 24 PDRhealth, supra note 8. 25 AYD, supra note 15, at 69, Winsberg & Yepes, supra note 23, at 256-58. 26 ROSENBERG ET AL., supra note 2, at 216-20. 27 AYD, supra note 15, at 965. 28 ROSENBERG ET AL., supra note 2, at 216. 29 Drugs , supra note 8. 30 PDRhealth, supra note 8. 31 Id. 32 Drugs , supra note 8. 33 PDRhealth, supra note 8 and dicyclomine.
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This case demonstrates the potentially catastrophic consequences of odontogenic infections. The patient, while elderly, was in good health and had an active lifestyle. In addition the bacteria that caused this infection were those routinely seen in.
In 2001, net gains on disposals related principally to the four major divestitures during the period: Sylachim, Porgs, Ela Medical and the direct holding in Laboratoires de Biologie Vgtale Yves Rocher see note D.1 ; . The gain on these four major divestitures included an allocation of part of the goodwill arising on the merger between Sanofi and Synthlabo, which was initially offset against consolidated shareholders' equity. D.24. Income taxes and brethine.
Dosage adjustment e.g. beta-blockers, ACE inhibitors, lipid therapy to target LDL recommendations of alternative medication due to side-effect, interaction with concurrent medication encouragement of concordance smoking cessation, hypertension clinics.
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The expected long-term rate of return on plan assets was 10% in 1993 and 199 the health-care cost trend rate was 12% at december 31, 1993 and 13% at december 31, 1992 and strattera.
733. In re "Agent Orange" Prod. Liab. Litig., 996 F.2d 1425 2d Cir. 1993 ; , cert. denied sub nom. Ivy v. Diamond Shamrock Chems. Co., 510 U.S. 1140 1994 In re Baldwin-United Corp., 770 F.2d 328 2d Cir. 1985 ; . But cf. Brown v. Ticor Title Ins. Co., 982 F.2d 386 9th Cir. 1992 ; , cert. dismissed as improvidently granted, 511 U.S. 117 1994 ; due process requires that plaintiffs with monetary claims be given right to opt out of class action settlement In re Real Estate Title & Settlement Servs. Antitrust Litig., 869 F.2d 760 3d Cir. 1989 ; . 734. See Kelly v. Merrill Lynch, Pierce, Fenner & Smith, 985 F.2d 1067 11th Cir. 1993 ; . 735. See, e.g., Winkler v. Eli Lilly & Co., 101 F.3d 1196, 120203 7th Cir. 1996 ; holding that an MDL transferee judge had authority to issue an injunction to protect the integrity of an order barring discovery of a particular matter In re Columbia HCA Healthcare Corp., Billing Practices Litig., 93 F. Supp. 2d 876 M.D. Tenn. 2000 ; issuing injunction under All Writs Act against competing motion to compel discovery filed in state court.
The majority of asthma advice appeared to be around inaccurate, over or under use of medication, with problems being identified with dosage and frequency, as well as inhaler use. There was a feeling amongst the pharmacists that this was due to customers not understanding the importance of medication use, with many customers not previously having had the opportunity to talk to a healthcare professional about medication issues. The provision of simple advice linked to asthma medication use, or concurrent OTC products were well received. Very few requests were made for lifestyle advice, although pharmacists would often bring this up in conversation with the customer. Customers appear to have felt at ease speaking to pharmacists about medication use, but were not as used to, or possibly felt uncomfortable in talking about advice that they would not normally get from the pharmacist. All the pharmacists interviewed commented on pharmacist resource as a factor that affected delivery of the service. Those working in single pharmacy environments were felt to be at disadvantage in service delivery. Even though resource was raised as an issue by all pharmacists during the interviews, the majority had managed to work around this for the service by involving other members of the pharmacy team, or by offering the asthma brief interventions. If resource had been made available, it is unclear whether the pharmacists would have delivered more of the brief interventions or full consultations. Linked to the resource issue, the pharmacists also believed that the constant demands on their time including requests by customers and staffs ; , was an issue that affected the delivery of the service. Better trained support staff would help to reduce the number of requests coming through by both customers and staff, and enable the pharmacists to utilise their time more effectively. The lack of customer time was felt to be a factor that affected service delivery, particularly when people were shopping in their lunch hours when their time was very limited. This was found to be particularly problematic in commuter towns, which could help to explain the demand for the informal brief interventions over the full consultations. The pharmacy environment was mentioned by one pharmacist which they felt could have put people off the service. It is unclear whether the pharmacist themselves felt uncomfortable not having a private consultation area to conduct the service, or whether it was the individual customers. The language barrier was discussed by one pharmacist as a factor that could have affected delivery of the service. This could be linked to the pharmacist's confidence in.
In four randomized, double-blind, placebo-controlled trials of nine weeks or less, atomoxetine was statistically more effective than placebo in reducing the adhd rating scale scores in children ages six to 18 years.
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Precedent has made it clear that exceptions to infringement, whether based on the FDA or "common law" exceptions, are VERY NARROW. In the case of the FDA, it is unlikely that uses outside approval of generic equivalents of known and previously approved drugs will be covered. In the case of the so-called "common law" exception, it is clear that even completely non-commercial activities infringe so long as they further an entity's "legitimate business objectives." Thus, even university research can constitute an infringement.
NPS Office use only 00CS25 Mr Green, a 42 year old man, presents to you with a three month history of intermittent non-specific epigastric discomfort after eating. There are no obvious symptoms of reflux such as heartburn. His job involves significant stress. He has a moderate alcohol intake, again on an intermittent basis. He is a non-smoker and his weight is steady. He thinks the discomfort may be worse for a day or two after drinking more than usual. He has no other symptoms. There is nothing of relevance in either his personal or family history. He has not taken any medication for the discomfort and takes no regular medications.
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CD25 and HLA-DR-expressing CD4 T cells increased transiently during IL-7 treatment by factors of 3.49 and 3.48, respectively, for CD25 and 4.88 and 3.32, respectively, for HLA-DR in macaques 3 and 4 ; . In contrast, in the CD8 T cell population, CD25 expression remained stable, whereas the number of HLA-DR-expressing cells increased in macaques 3 and 4 by factors of 3.76 and 4.29, respectively ; . IL-7-induced T cell activation was less pronounced in macaque 5 and was entirely absent in macaque 6. Thus, in responders, rsIL-7 transiently increased the activation of peripheral T cells, concomitant with increased proliferation. Both naive and memory T cell populations are expanded during rsIL-7 treatment We analyzed the effects of rsIL-7 treatment on the expansion of naive and memory T cell populations, by carrying out FACS analysis of the surface expression of CD45RA and CD62L. In this analysis, naive T cells were defined as CD45RAbright, CD62L T.
The CHMP reassessed the issue of potential suicidal behaviour in children and adolescents undergoing therapy with two classes of antidepressants: Selective Serotonin Re-Uptake Inhibitors SSRIs ; , and Serotonin and Norepinephrine ReUptake Inhibitors SNRIs ; . The active ingredients approved in Portugal which were re-evaluated were: citalopram, duloxetine, escitalopram, fluoxetine, mianserine, milnacipram, mirtazapine, paroxetine, reboxetine, sertraline, and venlafaxine. It has been concluded that suicide-related behaviour attempted suicide and suicide ideation ; , and hostility predominantly aggressiveness, opposition behaviour and anger ; were seen much more frequently in clinical trials in children and adolescents who had been taking these antidepressants, when compared to those taking placebo. Within this context, using these medicines in children and adolescents is not recommended, the approved indications excepted. Some of these drugs are indeed authorised for paediatric use for the treatment of obsessive-compulsive disorders. Atomoxetine although not marketed in this country ; is additionally approved for the treatment of attention deficit hyperactivity disorder. The physician may however at times prescribe these medicines to children or adolescents in well individualised cases, for the treatment of anxiety or depression. The CHMP recommends that under those circumstances patients be strictly monitored regarding the appearance of suicidal behaviour, self-aggressiveness or hostility, especially at the onset of therapy. Whenever therapy with this class of medicines is to be interrupted, its dosage should be gradually tapered for a period of several weeks or months, in order to prevent withdrawal reactions e.g.: dizziness, sensorial disorders, sleep disturbances, anxiety, headache!
The author, Peter T. Kissinger, Ph.D., is Chairman and CEO of BASi Bioanalytical Systems, Inc. ; , a pharmaceutical contract research firm headquartered inWest Lafayette, Indiana.
The collection of liquid-based Paps must be performed by a physician, a midwife as allowed via Regulation 682 of the Ontario Midwifery Act ; , or appropriately trained individual working under the direct supervision of a physician. A broom-type device Cervex-Brush ; is the recommended sampling device for the collection of cervical specimens for the liquid-based Pap. The Cervex-Brush is latex-free. The central bristles of the brush are inserted far enough into the cervical os to obtain cells from the endocervix. Use gentle pressure until the lateral bristles bend against the ectocervix. Maintain gentle pressure and rotate the Cervex-Brush 5 complete clockwise revolutions. The patient specimen is placed in the vial of preservative fluid and the handle of the brush is removed, leaving the head of the brush in the collection vial. The cytobrush may be used in addition to the Cervex-Brush when a narrow external os does not permit the central bristles to properly sample the endocervix. This may occur in multiparous women, post-menopausal women or following surgery of the cervix. The cytobrush should be cut and placed in the container along with the Cervex-Brush. The vial is capped tightly and labeled with the patient's last and first name or initial. Unlabelled vials will not be processed. Pregnant Patients: The Cervex-Brush may be used on pregnant patients up to the tenth week, in a manner similar to spatula. The central bristles of the Cervex-Brush should not be inserted deep into the canal but by firm pressure and rotation in a clockwise direction, the device may be used to sample the external os and ectocervix. A vaginal pool sample may also be obtained. Complete cytology requisition including patient and healthcare provider information and pertinent clinical information. Store and ship at room temperature. Send the vial and requisition to the laboratory. Specimens requiring expedited service must be clearly marked as such by the health care provider taking the sample. The typical designations are: ASAP or STAT.
It is not a substitute for the professional medical advice, diagnosis or treatment provided by your physician, other qualified health provider or any information included by the manufacturer with or on any product.
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