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Daiichi-Sankyo noted that Takeda had cited the `Oxford dictionary' definitions of `maintenance' and `optimal'. The Panel considered it to be `unfortunate' that the candesartan SPC and Olmetec SPC used different terms. In the circumstances the Panel considered that it was entitled to `assume' without giving any reasoning therefore ; that the `usual maintenance dose' of an antihypertensive was one which controlled most people's blood pressure. It further decided again without giving any rationale ; that the `optimal dose' was a dose which `encompassed consideration of its efficacy vs side effects and was the most favourable balance of the two but what was an optimal dose and possibly also the usual maintenance dose ; in one patient might be sub-optimal in another'. Daiichi-Sankyo noted that only three of the seven marketed sartans had a specifically defined maintenance dose. The SPCs for Micardis telmisartan ; , Teveten eprosartan ; , Diovan valsartan ; , and Olmetec, did not specify a recognised maintenance dose. Instead terminology such as `usually effective dose' and `recommended dose' as well as Daiichi-Sankyo's `optimal dose' was used in relation to other sartans. It was generally accepted that such terms corresponded in the mind of clinicians to the term `maintenance dose'. Daiichi-Sankyo further challenged the Panel's `assumed' definitions for `usual maintenance dose' and `optimal dose'. The Panel defined `usual maintenance dose' `as the dose which controlled most patients' blood pressure'. Daiichi-Sankyo did not regard either of the terms, `usually effective dose' telmisartan ; or `recommended dose' valsartan, eprosartan ; to come within the Panel's definition of the maintenance dose. A `usually effective dose' was normally defined as that dose which was `commonly encountered, experienced, or observed providing an expected response'; whilst a recommended dose would be considered the `approved, favoured or endorsed dose'. Despite this, these doses were widely regarded as the individual maintenance doses of the products in question. In short, if Olmetec 20mg was not to be considered a valid comparator for candesartan 8mg for maintenance purposes on the apparently sole basis that `optimal' and `maintenance' were not synonymous then it would seem that telmisartan 40mg, eprosartan 600mg, and valsartan 80mg, would each face similar difficulties. Daiichi-Sankyo submitted that the Panel's definition of `optimal dose' of the medicine as one which encompassed consideration of its efficacy vs side effects and was the most favourable balance of the two but what was an optimal dose and possibly also the usual maintenance dose ; in one patient might be sub-optimal in another must also be challenged. It was equally arguable that the dose required as the maintenance dose in one patient might be different to that required in another and thus might similarly be `sub-optimal'. Daiichi-Sankyo submitted that with specific reference to the Panel's definition of optimal dose referred to above it noted that in the regulatory process the determination of what was the optimal dose was made with reference to efficacy. With respect to the.
Dr. James E. Jim ; Hampton, Internal Medicine Written in January 2003 Years of Practice in Clarksville: January 1963 July 1987, 1995 to present Presently working part time at Public Health Department and Good Samaritan Ministry Missionary Physician to South Korea 1987 to 1994.
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Dr. Douglas Beirness: No, that's only in the possession part. Mr. Derek Lee: Is there no other definition in this section? Dr. Douglas Beirness: No. Mr. Derek Lee: No. That's the only one it's using. It's the only definition of drug that the Criminal Code is using here: schedules I through V of the CDSA. Are you recommending that there be another definition of a drug for specific use with this section? Mr. Jacques Lecavalier Associate, Research and Policy, Canadian Centre on Substance Abuse ; : If I may answer that, the definition that appears in CDSA is only applicable for the offence of possession; it is not applicable to the rest of the legislation. As it stands, the word "drug" is not defined either in the Criminal Code or in CDSA. That is why in our brief we propose that to make the definition clearer, the definition of the DRE program be used. We have provided specific text to that effect to the committee. Mr. Derek Lee: Well, Mr. Chairman-- The Chair: You have one more question, Mr. Lee. Mr. Derek Lee: It's just a follow-up. You're saying that there is no definition of drug for purposes of these other sections. Mr. Jacques Lecavalier: No. Mr. Derek Lee: Okay. Thank you. The Chair: Mr. Norlock. Mr. Rick Norlock Northumberland--Quinte West, CPC ; : This question will be for the toxicologist. Ms. Treacy, probably most people out there in the real world, let's call it, have known for years that alcohol causes impairment, and the more alcohol you have, the more impaired you become, except perhaps in situations where some people are a little more resistant than others. Tell me if I'm wrong. Canada is not quite the same as other countries. The law says that after a certain amount you're deemed to have too much alcohol in your system to be able to legally drive a motor vehicle, irrespective of your resistance to the effects of alcohol. Would that be correct? Ms. Shirley Treacy: That's correct regarding alcohol, yes. Mr. Rick Norlock: Would it also be correct that, in toxicological terms, alcohol is a poison? Ms. Shirley Treacy: Well, yes. Actually, anything can be a poison if you take enough of it. Yes, your body does think of alcohol as a poison; it tries to get rid of it. Sure. Mr. Rick Norlock: So we know that all alcohol causes some degree of impairment and that the law says that after so much alcohol you are not legally able to drive. Ms. Shirley Treacy: That's a specific offence, yes. Mr. Rick Norlock: Because we've studied alcohol to death in this country. Ms. Shirley Treacy: Yes and effexor.
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Page 55 Index Dextrose 5%-1 2ns-Kcl, 45 DEXTROSE 5%-ELECTROLYTE #48, 44 DEXTROSE 5%-ELECTROLYTE #75, 44 dextrose 5%-lactated ringers, 44 dextrose 5%-water, 30 Dextrose In Lactated Ringers, 44 Dextrose In Water, 29-30 DEXTROSE W ELECTROLYTE A, 44 dhcodeine bt acetaminophn caff, 8 Diabeta, 15 dialysis solutions, 37 Diamox, 30 DIANEAL PD-2 W 3.5% DEXTROSE, 37 DIANEAL W 1.5% DEXTROSE, 37 DIANEAL W 2.5% DEXTROSE, 37 DIBENZYLINE, 47 diclofenac potassium, 7 diclofenac sodium, 7 dicloxacillin sodium, 12 didanosine, 26 Didronel, 39 DIDRONEL, 39 DIFFERIN, 47 diflorasone diacetate, 20 diflorasone diacetate emoll, 20 Diflucan, 16 diflunisal, 7 digoxin, 31 dihydroergotamine mesylate, 47 Dilantin, 14 DILANTIN, 14 Dilaudid, 8 DILAUDID, 8 DILAUDID-HP, 8 diltiazem hcl, 28 DILTIAZEM HCL, 28 DIOVAN, 44 DIOVAN HCT, 44 DIPENTUM, 19 diphenhydramine hcl, 35 diphenhydramine tannate, 35 diphenoxylate hcl atrop sulf, 15 DIPHTHERIA-TETANUS TOXOID, 48 dipivefrin hcl, 40 Diprolene, 19 dipyridamole, 50 Disalcid, 8 and elocon.
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Jsrgensen 36 ; prepared the compounds [Rh NH, ; , ]X where X NO NO, .$HNO, 37 ; , C1, Br, I, ; SO ~I.SO ; Br.SO ; PO + NaP, O : [PtC16]y : cl[PtC16] and H20, X [PtCl, ] ; . He also prepared [RhH, O H3N, H3N, X Rose0 s s l H3Ny H3N, X NH, ; , ] NO, ; , .HNO, 37 ; and later, in his first H3N, H3N, H3N, X article attacking Werner's views 38 ; , H3Ns H3N, X H20, X [Rh NH3 ; 61 [Rhci6i and [RhC' NH, ; J, [RhCl, ], . The hexaamminerhodium 1II ; salts, modern, aquapcntaammines, [RH, 0 NH3 ; , ]X3 ; to which he assigned the monomolecular formula Rh, 6NH, ; X3, are very stable; after the H3N, X passage of more than four decades the compoHJ, H3N, X L u adtr ~ H3N, H3Ny H3N, X sition of Jsrgensen's samples was found to be H3N, H3N, H3N3 X unchanged 39 ; . H3N, H, N, x In his last article on rhodium, published in H3N3 X 1903 40 ; , Jsrgensen returned to his work of modern, hexaarnmines, [R NH, ; , ]X3 ; two decades earlier 31 ; . Because of the analoIn fact, in the case of the luteorhodium gous behaviour of rhodium and iridium he hexaamminerhodium II1 salts, Jsrgensen's decided that the chloropentaamminerhodproposal was a sheer prediction, for he did not ium II1 ; chloride used in his determination of succeed in preparing these compounds until the atomic weight of rhodium 31 ; might have rdu. contained i i i Using [RhCl NI-I, ; , ]Cl, purithe year 1891. Jsrgensen next described, in a 3-part article, fied by two different methods, he repeated his the detailed preparation, properties and reac- atomic weight determination and obtained the tions of [Rh l ONH 2HZO ; &, roseorhodium previous value. salts [RhH, O NH, ; , ]X where X OH, NO NO, .HNO C1, Br, : SO ; I.SO, ; , iHPO Conclusion Like Alfred Werner, Jsrgensen was primarily : NaP, O, ; , f[co cN ; , I, ; [Fe CN ; , I, OJ [ [PtClJ or o ~tcl6] interested in one of the most fundamental prob4W03 ; 33 NO, ; , Rh 10NH3 ; &, nitratopurpureo- lems of chemistry, the nature of the chemical and evista.
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None of the Company's marketable securities at December 31, 2004 have been in a continuous unrealized loss position for 12 months or longer. The unrealized losses on the Company's investments in corporate debt and government agency securities were caused by interest rate increases. The contractual terms of these investments do not permit the issuer to settle the securities at a price less than the amortized cost of the investment. Because the decline in market value is attributable to changes in interest rates and not credit quality, and because the Company has the ability and intent to hold these investments until a recovery of fair value, which may be maturity, the Company does not consider these investments to be other-than-temporarily impaired at December 31, 2004. F-14 and flomax.
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Summary. Receptor binding studies on rat cortical membranes were used to characterize the' NMDA receptor in aged rats 22 months ; treated for 20 months with a memantine containing diet delivering 30mg kg day in comparison to aged and young adult rats treated with control-diet. Spatial memory impairing effects of + ; -MK-801 O.l6mg kg ; in the radial maze was not altered within the course of memantine-treatment up to 16 months ; . However, chronic memantine-treatment significantly increased the number of [H]MK-801 binding sites and the affinity of [Hlglycine. A non-significant trend to such changes was also seen in aged-control rats. Glycine-dependent [H]MK-801 binding functional binding under non-equilibrium conditions at a fixed L-glutamate concentration ; revealed that a decreased ability of glycine to stimulate channel opening in aged rats was partially attenuated by the longterm memantine treatment. Furthermore, an increased ability of spermidine to enhance [H]MK-801 binding in aged-control rats was even more pronounced in the aged memantine-treated group. Together these findings may indicate that changes in functional receptor-channel properties during the process of aging occur prior to a detectable loss of binding sites and that memantine enhances an endogenous compensatory mechanism triggered by glutamatergic hypofunction which is suggested to take place in aging. Keywords: Memantine, N-methyl-D-aspartate NMDA ; , aging, [H]MK-801, [H]glycine, spermidine, radial maze. Introduction The amino-adamantane derivative memantine 3, 5-dimethyl-l-aminoadamantane ; has been used clinically for many years for different indications and flonase.
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TREATMENTS FOR METABOLIC DISORDERS Cardiac- amlodipine Norvasc ; , aspirin all formulations, all generics ; , atenolol Tenormin, all generics ; , carvedilol Coreg ; , clonidine Catapres, all formulations, all generics ; , digoxin all manufacturers ; , dilitiazem Cardizem, CD, SR, Cardia XT, Tiazac ; , enalapril Vasotec, all generics ; , furosemide Lasix, generics ; , hydrochlorothiazide generics ; , levothyroxine Synthroid, Levothyroid, Levoxyl, generics ; , lisinopril Prinivil, Zestril, all generics ; , metolazone Mykrox, Zarosolyn, all generics ; , metoprolol Lopressor, Toprol SL, all formulations, all generics ; , nifedipine Adalat, CC, Procardia, XL, all generics ; , propranolol Inderal, all generics ; , spironolactone Aldactone, all generics ; , triameterene Dyrenium, generics, all comibinations ; , valsartan Diovan ; , verapamil Calan, SR, Covera, Isoptin, Verelan, generics ; . Diabetic- acarbose Precose ; , clorpropamide Diabinese ; , glimepiride Amaryl ; , glipizide Glucotrol ; , glyburide Diabeta, Micronase ; , insulin all types ; , metformin Glucophage ; , pioglitazone Actos ; , rosiglitazone Avandia ; , tolazamide Tolinase ; , tolbutamide Orinase ; . Hyperlipidemia- atorvastatin Lipitor ; , cholestyramine Questran ; , colesevelam Welchol ; , ezetimibe Zetia ; , fenofibrate Tricor ; , gemfibrozil Lopid ; , niacin Niaspan, Nicotinic Acid, Slo-Niacin ; , pravastatin Pravachol ; , rosuvastatin Crestor ; . Wasting- carafate Sucralfate ; , cyproheptadine Periactin ; , diphen-atopine Lomotil ; , dronabinol Marinol ; , esomeprazole Nexium ; , famotidine Pepcid ; , lansoprazole Prevacid ; , megestrol acetate Megace ; , omerprazole Prilosec ; , pancrease Enzymes all formulations, generics ; , pantoprazole Protonix ; , rabeprazole Aciphex ; , ranitidine Zantac ; , testosterone replacement products All types ; . ALL OTHERS albuterol inhaler Ventolin ; , albuterol ipratropium Combivent ; , alprazolam Xanax ; , amitriptyline Elavil ; , amoxapine Asendin ; , azelastine Astelin ; , beclomethasone Beclovent, Vanceril ; , brompheniramine Dimetapp, various ; , budesonide Pulmicort ; , buproprion Zyban, Wellbutrin ; , carbamazepine Tegretol ; , celecoxib Celebrex ; , cetirizine Zyrtec ; , chlordiazepoxide Librium ; , citalopram Celexa ; , clemastine Tavist ; , clomipramine Anafranil ; , clorazepate Tranxene ; , codine pain relievers, desipramine Norpramin ; , desloratadine Clarinex ; , dexamethasone all forms ; , dexchlorpheniramine Polaramine, various ; , diazepam Valium ; , diclofenac Cataflam, Voltaren, generics ; , diphenhydramine Benadryl ; , estazolam Prosom ; , ethosuximide Zaronton ; , etodolac Lodine, generics ; , fenoprofen Nalfon, generics ; , fentanyl Transdermal Duragesic ; , fexofenadine Allegra ; , flunisolide Aerobid ; , fluoxetine Prozac ; , flurazepam Dalmane ; , flurbiprofen Ansaid, generics ; , fluticasone Flovent ; , fluticasone salmeterol Advair Disdus ; , fluvoxamine Luvox ; , gabapentin Neurontin ; , hemorrhoidal creams & suppository, hepatitis A, B vaccine Havrix, Vaqta, Energix-B, Recombivax HB, Comvax, Twinrix ; , hydrocodone and derivatives, hydroxyzine Vistaril, generics ; , ibuprofen Motrin ; , imipramine Tofranil ; , ipratropium Atrovent ; , isoproterenol Isuprel ; , ketoprofen Orudis, generics ; , klonopin Clonazepam ; , lamotrigine Lamictal ; , levetiracetam Keppra ; , lexapro Escitalopram ; , lithium Eskalith, Lithobid ; , loperamide HCL Imodium ; , lorazepam Ativan ; , loratadine Claritin ; , maprotiline Ludiomil ; , meclofenamate generics ; , meloxicam Mobic ; , meperidine Demerol, generics ; , metaproterenol Alupent ; , mirtazapine Rameron ; , montelukast Singulair ; , morphine MSIR, Oramorph SR, MS Contin ; , naproxen Aleve, Anaprox, Naprosyn, Anprelan ; , nabumetone Relafen ; , nefazodone Serzone ; , nembutal Pentobarbital ; , nicotene replacement products - all forms, nizatidine Axid ; , nortriptyline Aventyl, Pamelor ; , nystatin triamcinolone cream, olanzapine Zyprexa ; , oxaprozin Daypro ; , oxazepam Serax ; , oxycodone Endocodone, Oxycontin, Roxicodone, OxyIR, OxyFAST, M-oxy ; , paroxetine HCL Paxil ; , phenytoin Dilantin ; , probenecid, prochloparazine Compazine ; , promethazine Phenergan, generics ; , propoxyphene Darvon ; , protriptyline Vivactil ; , quetiapine Seroquel ; , rofecoxib Bioxx ; , salmeterol Serevent ; , sertraline Zoloft ; , sulindac Clinoril ; , temazepam Restoril ; . terbutaline Brethine, Brethaire ; , tiagabine Gabitril ; , tolmentin Tolectin ; , triazolam Halcion ; , triamcinolone Azmacort ; , trimipramine Surmontil ; , valdecoxib Bextra ; , valproic Acid Depakote, Depakene ; , venlaxifine HCL Effexor ; , zolpidem Ambien.
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The British Columbia Cancer Agency is the primary referral centre for patients diagnosed with hematolymphoid malignancies in the province of British Columbia, Canada. A total of 116 cases of MALT lymphoma were diagnosed at BCCA between 1988 and 1997. Eleven cases of pathologically confirmed MALT lymphomas were submitted for cytogenetic analysis at the time of the initial evaluation Eight of 11 cases yielded successful cultures and the presence of a clonal karyotype was identified using standard cytogenetic methodology. In addition, a single case of orbital MALT lymphoma with a clonal karyotype has been obtained through our consultative practice from University of Nebraska Medical Center. These nine cases of MALT lymphoma with a clonal karyotype are the subject of this report.
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You, please execute the enclosed copy of this letter as indicated below and return it to me your earliest opportunity. Yours truly, DRAXIS PHARMA INC. s Martin Barkin Per: Martin Barkin, M.D., F.R.C.S.C. Chairman of the Board of Directors of Draxis Pharma Inc. and Chief Executive Officer of Draxis Health Inc. I accept the above-noted terms of employment with Draxis Pharma Inc. as President, I agree to comply with and be bound by the terms of employment outlined in this Agreement. Dated at , the day of , 2003.
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The pharmacokinetics of tenofovir have not been evaluated in non-hemodialysis patients with creatinine clearance 10 mL min; therefore, no dosing recommendation is available for these patients. HOW SUPPLIED VIREAD is available as tablets. Each tablet contains 300 mg of tenofovir disoproxil fumarate, which is equivalent to 245 mg of tenofovir disoproxil. The tablets are almond-shaped, light blue, film-coated, and debossed with "GILEAD" and "4331" on one side and with "300" on the other side. They are packaged as follows: Bottles of 30 tablets NDC 6195804011 ; containing a desiccant silica gel canister or sachet ; and closed with child-resistant closure. Store at 25 C excursions permitted to 1530 C 5986 F ; see USP Controlled Room Temperature ; . Do not use if seal over bottle opening is broken or missing. Gilead Sciences, Inc. Foster City, CA 94404 May 2007 VIREAD, EMTRIVA and TRUVADA are registered trademarks of Gilead Sciences, Inc. ATRIPLA is a trademark of Bristol-Myers Squibb & Gilead Sciences, LLC. All other trademarks referenced herein are the property of their respective owners. 2007 Gilead Sciences, Inc. All rights reserved. 21-356-GS-020.
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