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When subjects who were unresponsive to citalopram had sustained-release bupropion or buspirone added to citalopram, there were similar remission rates of 2 7 and 3 1%, respectively.
Seizure. The chance of this happening increases if you: have or have had a seizure disorder for example, epilepsy have or have had an eating disorder for example, bulimia or anorexia nervosa take more than the recommended amount of Bupropion-RL; are taking any other medicine containing bupropion; have had a head injury; are a heavy drinker; or suffer from diabetes. Table 1. Published Randomized Controlled Clinical Trials of Bupropion SR for Treatment of Tobacco Dependence. Drug Name Biaxin XL Bisoprolol fumarate Bisoprolol fumarate HCTZ Blephamide Blephamide S.O.P. Brometane DX Bromfenex-PD Brompheniramine w pseudoephed Bumetanide Bupropion HCL Buspirone HCL Butalbital compound Butalbital apap caffeine Butalbital caff apap codeine Byetta Caduet Calan SR Calcitriol Camila Capex shampoo Capital w codeine Captopril Captopril hydrochlorothiazide Carac Carbamazepine Carbatrol Carbidopa levodopa Carbofed DM Cardizem CD Cardura Carisoprodol Carmol 40 Carnitor Carteolol HCL Cartia XT Casodex Catapres tabs. Catapres-TTS Cefaclor Cefadroxil Ceftin tablets Cefuroxime Cefzil Celebrex Celexa Cellcept.
Between January 1, 1999 and December 31, 2002, 48 patients from 7 different Swiss centers were included in the study. The demographic characteristics age, gender, body mass index [BMI], ongoing therapy for arterial hypertension, and diabetes mellitus ; were not significantly different between the 3 groups Table 1 ; . The mean serum levels of ALT and AST were elevated in the 3 groups at baseline and not significantly different. None of the 6 histologic parameters was significantly different among the 3 groups Table 2 ; . It was not possible to retrieve the slides of the initial liver biopsy of 1 patient in each group, but none of these 3 patients completed the study. Eight patients dropped out, 3 in the UDCA Vit E arm, 3 in the UDCA P arm, and 2 in the P P arm Figure 1 ; . Importantly, no patient dropped out because of side effects. In none of the 3 groups the BMI changed significantly during the 2 years, and the mean BMI remained similar between the 3 groups until completion of the study. BMI at baseline was 31.1 7.4, 29.7 and 29.5 4.7 kg m2 in the UDCA Vit E, UDCA P, and P P groups, respectively. BMI at 1 year was 30.1 7.6, 29.7 and 29.8 2.3 kg m2 in the UDCA Vit E, UDCA P, and P P groups, respectively. BMI at 2 years was 31.1 6.5, 30.1 and 31.0 3.7 kg m2 in the UDCA Vit E, UDCA P, and P P groups, respectively. Regarding the biochemical response, there was a significant decrease in the mean serum ALT levels in the UDCA Vit E arm at 1 year and at 2 years. Moreover, the mean ALT serum levels reached normal range Figure 2A ; . There was also a significant decrease in the ALT levels in the UDCA P arm, but these values did not reach normal range. The number of patients with normal ALT at 1 year and at 2 years was 10 and 8 in the UDCA Vit E group, 5 and 5 in the UDCA P group, and 4 and 3 in the P P group. The improvement of the serum ALT levels was larger in the UDCA Vit E arm than in the UDCA P arm, and it was significantly larger than the change measured in the P P arm Figure 2B ; . The ALT changes were not significantly different in the UDCA P arm in comparison to the P P arm. There was also a significant decrease in the mean serum levels of AST in the UDCA Vit E group at 1 year and at 2 years in comparison to the baseline measurements Figure 2C ; . Moreover, these values reached normal range. There was a slight decrease of the serum AST values in the UDCA P arm that was not statistically significant. The number of patients with normal AST at 1 year and at 2 years was 10 and 11 in the UDCA Vit E group, 7 and 8 in the UDCA P group, and 5 and 4 in the P P group. The changes of serum AST levels were statistically significant in the UDCA Vit E arm in comparison to the P P arm Figure 2D ; . This was not the case in the UDCA P arm. Thirty-two patients had a second liver biopsy. Eight patients did not have a second liver biopsy, 2 in the UDCA Vit E arm, 4 in the UDCA P arm, and 2 in the P P arm. Each of the 6 features of NASH had a better score at the end of treatment in the combination therapy group, yet for only one, steatosis, the improvement was statistically significant. The other 5 features did not improve significantly Figure 3A ; . None of the 6 itemized scores were significantly better in. The bupropion zyban bupropion zyban marketing that prompt natural zyban digestive system to capture and isoptin. The main part of this study was a single page questionnaire which asked the surgeons whether they would recommend Questionnaires about golf injuries were sent to all 461 memregular patient participation in particular sports after surgery bers of the Royal Worlington and Newmarket Golf Club in for each of 28 sports. The results are shown in the Tables. 1991 - including gentlemen, lady and university members. Replies were obtained from 41% of gentlemen and 47% of Golf 100% ; , swimming 95% ; cycling 95% ; and sailing lady members - university members not being mentioned. were recommended for both; recommended sports were sup- The average age of responders was 50 years, who had played ported by more than 75% of responders. Arange of energetic golf for a mean of 30 years, and who played about four rounds and contact sports were not recommended by more than 75% a month. Variation was wide! of responders - including karate, soccer and water-skiing. Other activities, like tennis, ice-skating and aerobics had in- Seventy-two injuries were sustained when playing golf by termediate scores, and were neither recommended nor not. 61 golfers of the 193 members replying ; . Of the golf injuries This paper had a literature search to identify reports on hip of eight women, seven involved elbow shoulder or wrist. , or knee surgical procedures and sports. In active golfers who Men 53 ; had more varied injuries, the most frequent of the had a knee replacement in the USA, the majority report a injuries reported being wrist 15 ; , back 13 ; , and then injumild ache while playing, usually on the target side [3]. ries to various joints and extremities. Impacts by balls 6 ; and References: 1 ME Batt. A survey of golf injuries in amateur golfers. British Journal of Sports Medicine 1992 26: 63-5. BJ McGrory, MJ Stuart, FH Sim. Participation in sports after hip and knee arthroplasty: review of the literature and survey of surgeon preferences. Mayo Clinic Proceedings 1995 70: 342-8. WJ Mallon, JJ Callaghan. Total knee arthroplasty in active golfers. Journal of Arthroplasty 1993 8: 299-306. clubs 1 ; were relatively rare, as was attack by bees 1. Learning Objectives: Upon completion of the program, the health care provider should be able to: 1. Assess an adult smoker's readiness to quit smoking 2. Implement the "5 A's" of intervention 3. Describe the effectiveness of FDA-approved first-line pharmacotherapies for smoking cessation e.g., nicotine-replacement therapy, bupropion ; 4. Recognize the efficacy of behavioral therapies for smoking cessation 5. Implement the basic elements of a counseling intervention for smoking cessation Sponsorship: Sponsored by the Illinois Academy of Family Physicians Family Practice Education Network IAFP FPEN ; . Accreditation: The Illinois Academy of Family Physicians Family Practice Education Network is accredited by the Accreditation Council for Continuing Medical Education ACCME ; to provide continuing medical education for physicians. Credit Designation: The Illinois Academy of Family Physicians Family Practice Education Network designates this educational activity for a maximum of 2.0 category 1 credits towards the AMA Physician's Recognition Award. Each physician should claim only those hours of credit that he she actually spent in the educational activity. Expiration: March 15, 2007 This activity has been reviewed and is acceptable for up to 4.0 Prescribed credit s ; by the American Academy of Family Physicians. 2.0 Prescribed credit s ; conform to AAFP criteria for evidence-based CME clinical content. The amount of EB CME has been doubled to reflect 2 for 1 credit for only the EB CME portion. Term of approval is for two-year s ; from beginning distribution date of 3 15 05, with option for yearly renewal. When reporting CME credit, AAFP members should report total Prescribed credit earned for this activity. It is not necessary for members to label credit as evidence-based CME Prescribed or Elective for CME reporting purposes. Support: This medical education program, Adult Smoking Cessation: Intervention Strategies for Primary Care Providers, was made possible through an unrestricted educational grant from the Illinois Department of Public Health and captopril.
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There are additional medications that have been reported to cause and contribute to ototoxicity including: amphotericin B, chloramphenicol, minocycline, sulfonamides, methotrexate, flecainide, lidocaine, metoprolol, procainamide, propranolol, amitriptyline, bupropion, carbamazepine, doxepin, fluoxetine, imipramine, lithium, trazodone, and benzodiazepines. Risk Factors: The degree of ototoxicity of most medications is often controversial. The majority of patients who develop ototoxicity often present with comorbid conditions that will predispose them to developing auditory problems, or they may have an underlying hearing deficiency before exposure to the drug. Some of the risk factors for developing ototoxicity are: Previous use of ototoxic medication Concomitant administration of multiple ototoxic agents Administration of ototoxic medications for prolonged period of time High serum levels of ototoxic agent. Int.Cl.7 A21D10 02; A21D6 00. LOW PRESSURE REFRIGERATED DOUGH PRODUCT. THE PILLSBURY COMPANY and doxazosin. In summary, the elderly with BD should be treated with standard mood stabilizers, the same as younger adults. However, lithium is more difficult to use in the elderly, perhaps providing a greater role for divalproex or possibly lamotrigine. Antidepressants with the fewest drug interactions eg, bupropion, sertraline, and citalopram ; may be more useful in combination therapy. Among antipsychotics, clinicians should use low doses of agents with the likelihood of the fewest adverse events in the individual patient. While treatment of elderly patients may often follow the same principles applied to other patient groups, there is a scarcity of data specific to late-life BD. Further research is needed to increase the knowledge base and facilitate development of comprehensive treatment guidelines specific to the elderly population's needs. All these aspects were very important when I considered which choices were right for me to treat my hepatitis C. Every form of treatment has its own positives and negatives, its own potential risks and rewards. I intend to stay on my current protocol while I continue to explore other options as they become available. As western therapies improve, I will re-evaluate my choices and decide whether or not this form of therapy is appropriate for me. I will also continue to explore various CAM treatment options. I intend to try to document and understand CAM successes or lack thereof, and make decisions based on what I learn. My long-term treatment goals remain unchanged: 1. 2. to have good health for as long as possible, and to get rid of the hepatitis C virus and mesylate.
Sectors of the community and is virtually impossible to trace. It is a postulate of the organized crime literature see, Potter and Cox 1989 ; that where government has failed to deal with social problems, the illicit economy often steps in and lends a hand. This is clearly the case in the marijuana-producing areas of Kentucky. It is hard to argue with jobs, money, and the ability to accumulate disposal consumer income in areas where other social interventions have failed. In times past, the "moonshiners" of Kentucky played a major role in the state's illicit economy and enjoyed considerable public support. The modern day equivalent of the "moonshiner" is the marijuana grower Herald, 1989: 2; Maurer, 1974 ; . Clay County marijuana cultivator J.C. Lawson is regarded as something of a local "Robin Hood, " providing funds to repair the roof of a church and even providing rattlesnakes for use by local snake-handlers in their religious observations. Closely tied to the issue of community support is the issue of public corruption. Kentucky has had an upsurge in drug-related corruption. Sheriffs, jailers, police officers, a former state police commissioner and other public officials have been implicated in an increasing number of drug-corruption and drug-protection activities since 1982. In one rural, eastern Kentucky county, the sheriff and presiding judge were convicted of supplying protection for drug traffickers. In the same case, a high-ranking state police officer was charged with corruption. In Clinton County, the federal courts ordered the state and local courts to give up jurisdiction over marijuana cases after a study revealed that 5 out of every 6 marijuana cases in that county resulted in dismissal or acquittal. Several former law enforcement officers in Lexington have also been implicated in drug trafficking, involving hundreds of pounds of cocaine, and the list of examples could include at least a dozen others. 6 ; Law enforcement efforts against marijuana have resulted in the creation of organized crime groups. Perhaps the most troubling aspect of enforcement efforts against marijuana has been the creation of highly organized and efficient criminal organizations in the marijuana industry. It is an axiom of the literature on enforcement of victimless crime laws that enforcement is consistently directed in a highly selective manner at those who are least organized, least efficient, and least able to defend themselves Schur, 1965 ; . This results in the unintentional strengthening of criminal organizations which gain a larger share of the market because of selective.

Abstract T721 Table Gene Polymorphism No. of patients 108 203 94 AA AC 47.8 43.6 8.7 Primary graft function No % ; ACE DD DI II Yes % ; 31.4 43.1 23.5 At least one rejection episode No % ; 27.9 46.2 23.1 and catapres. Association Scientffic Sessions, a trend could be sensed that a more controlled set of surgical indications was being developed on balance of risks and benefits with more precise knowledge and experience. However, the consensus is still not conservative. The enthusiastic acceptance of aortocoronary bypass may prove to be well justified. However, the "natural" history of severe angina pectoris is unknown, and is unlikely to be forthcoming shortly as a baseline for evaluation of the procedure. Efficacy of new surgical procedures has rarely been evaluated by a parallel series of unoperated cases, nor does it seem likely to be. Patients are often unwilling to give informed consent for participation in a random allocation study involving the withdrawal of a possibly beneficial treatment. Nor will most physicians be likely to consent to change and cooperate with centers attempting to conduct such studies. W. W. L. Glenn reported in a presidential address at the American Heart Association 1971 Scientific Session that a prospective study of the effects of revascularization surgery is planned by the National Heart and Lung Institute of the U. S. Public Health Service. Preoperative and postoperative courses will be compared to provide a clue to the natural history of severe coronary disease and how it is altered. At present it seems futile to resist liberal indications for a procedure while awaiting acquisition of comprehensive statistical evidence of its values and risks. All new procedures must go through a period of development of technical skill and diagnostic methodology with variable hazards to the patient. With competent teams current evidence indicates improvement of these guidelines and concomitant lowering of risks. Elements entering into the changing picture of risks and benefits are: 1 ; Postoperative reports of decreased angina seem valid but are difficult to evaluate because of bias by either the physician or patient and possibly by the favorable effect of enforced rest. 2 ; Functional improvement of the myocardium has been clearly demonstrated after successful venous bypass, 46 especially if removal of. Fox et clean shave received by bupropion both with augmentin changing and cefaclor. Bupropion comes in two formulations: immediate and sustained release.

Other patients is most lasix minorities since that in bupropion calculated and cefuroxime.

Tricyclic antidepressants and, 59 Blood-brain barrier, leptin hormone and, 6466 Body function. See Disorders of sense and body function Bolanos, C.A. neurotrophic factors in addictive disorders, 60 Borda, Tania inflammatory processes and schizophrenia, 45 Brain death organ donation and, 3738 tests for, 37 Brain development ASPM gene and, 17 autism and, 1213 fundamental questions about, 3 genetic syndromes, 1718 microcephalin and, 1718 overnutrition or undernutrition and, 64 Brown, Malcolm brain regions responsible for memory, 8384 Bunge, Mary Bartlett spinal cord injury treatment, 2930 Bupropion, nicotine addiction treatment, 61 Burstein, Rami triptan treatment for migraine headaches, 5152 Byram, Susanna neuroprotection research, 46 C cAMP. See Cyclic AMP Cancer. See Pain; Paraneoplastic neurological syndromes Casanova, Manuel minicolumns and autism, 1314, 15 Case Western Reserve University neuroethics courses, 36 CBT. See Cognitive behavioral therapy Central nervous system injuries biosynthetic scaffolds, 2, 3233 bridging the damaged spinal cord, 2, 2931 CREB and, 3031 cyclic AMP and, 2931 decorin and, 31 glial scar and, 28, 31 goals of research, 28 neurotrophin-3 and, 30.
Ophthalmoscopy examination: Assesses internal ocular structures, noting optic disc atrophy, papilledema, retinal hemorrhage, and microaneurysms. Slit-lamp examination provides three-dimensional view of eye structures, identifies corneal abnormalities change in shape, increased IOP, and general vision deficits associated with glaucoma. Visual acuity tests e.g., Snellen, Jayer ; : Vision may be impaired by defects in cornea, lens, aqueous or vitreous humor, refraction, or disease of the nervous or vascular system supplying the retina or optic pathway. Visual fields e.g., confrontation, tangent screen, perimetry ; : Reduction of peripheral vision may be caused by glaucoma or other conditions such as cerebrovascular accident CVA ; , pituitary brain tumor mass, or carotid or cerebral artery pathology. Tonography measurement: Assesses intraocular pressure normal: 1220 mm Hg ; . acute angle-closure glaucoma, IOP may be 50 mm higher. Gonioscopy measurement: Helps differentiate open-angle from angle-closure glaucoma. Provocative tests: May be useful in establishing presence type of glaucoma when IOP is normal or only mildly elevated. Glucose tolerance test fasting blood sugar FBS ; : Determines presence control of diabetes, which is implicated at times in secondary glaucoma and citalopram and bupropion. We have recently commented upon the failure of low-dose aspirin and statins in the primary prevention of cancer. So what about Vitamin E? Vitamin E has antioxidant properties leading to the hypothesis that it can prevent the development of cardiovascular disease and cancer. There is, of course, some basic research encouraging this hypothesis. This has recently been tested in a prospective randomised trial comparing 600 IU of vitamin E and placebo on alternate days. This study, the Women's Health Study, included 39, 876 apparently health US women aged at least 45 years and followed them for over ten years. And the results--Vitamin E taken every other day provided no overall benefit for major cardiovascular events or cancer and did not affect total mortality. These data do not support recommending vitamin E supplementation for cardiovascular disease or cancer prevention among healthy women. Another theory put to the sword. The withdrawal has been phased over a period of up to months, with the withdrawal of the license timed for the end of 2007. Some manufacturers have already withdrawn co-proxamol. The MHRA has issued pain management giudance to help doctors find the best alternative analgesia options for individual patients see mhra.gov ; After the end of 2007, when the licence for coproxamol is to be cancelled, there is a provision for the supply of unlicensed co-proxamol, on the responsibility of the prescriber. Varenicline: the Cochrane review Varenicline is an oral selective partial agonist of nicotinic receptors, designed to block the rewards from, cigarette smoking and reduce craving. It is licensed as an aid to smoking cessation in adults. The Cochrane review stated the following: Varenicline increased the odds of successful long-term smoking cessation approximately threefold compared with unassisted quit attempts. In trials reported so far, more participants quit successfully with varenicline than with bupropion. Varenicline's effectiveness in preventing relapse has not been clearly established. The main adverse effect of varenicline is nausea, but this is mostly at mild to moderate levels and tends to reduce with habituation. There is a need for independent trials of varenicline versus placebo, to test the early findings. There is also a need for direct comparisons with nicotine replacement therapy, and for further trials with bupropion, to establish the relative efficacy of the treatments. A New Medicines Alert on varenicline is available at npc.nhs new drugs . This states and chloromycetin.
At the initial dosing of bupropion, some patients report complications such as headache and dizziness but, generally, these symptoms will dissipate with treatment. Presence or absence of a panic component will dictate choice of medications for these patients.

Message sequence charts MSCs ; are a well established visual formalism for the description of inter-working of processes or objects. There is also a standard for the MSC language, which has appeared as a recommendation of the ITU [1]. The standard defines the allowed syntactic constructs, and is also accompanied by a formal semantics [2] that provides unambiguous meaning to basic MSCs. Despite the widespread use of MSCs and the foundational efforts cited above, several fundamental issues have been left unaddressed. One of the most basic of these is, quoting [3]: "What does an MSC specification mean: does it describe all.

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Indications and usage for the treatment of functional bowel irritable bowel syndrome. Bmj 308 6920 ; : 21-6, 199 hurt rd, sachs dp, glover ed, et al: a comparison of sustained-release bupropion and placebo for smoking cessation and isoptin. Zyban and wellbutrin are the same exact medication, bupropion hydrochloride, but are marketed differently.

Pulmonary - critical care associates of east texas jeffrey shea catherine martinez, about our practice our home page our physicians our office patient information terminology medication medication costs pulmonary topics pulmonary procedures web sites of interest new patient packet welcome to the practice registration forms critical care info for families procedure photos bronchoscopy thoracentesis advanced directives about advanced directives dnr form pdf ; smoking cessation registration web site links bet program physician enrollment feedback information satisfaction survey feedback form what's new what's new page objectives know the purpose of pulmonary rehabilitation know the components of the pulmonary rehabilitation program know the potential patient outcomes from pulmonary rehabilitation what is pulmonary rehabilitation.

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Clonidine and nortriptyline. Consider prescribing second-line agents for patients unable to use first-line medications because of contraindications or for patients for whom first-line medications are not helpful. Monitor patients for the known side effects of second-line agents. Bupropion SR and nicotine replacement therapies, in particular nicotine gum, have been shown to delay, but not prevent, weight gain. Bupropion SR and nortriptyline appear to be effective with this population. We undertook a telephone-based follow-up survey of postmenopausal women who had participated in a large community-based osteoporosis screening project that was conducted by our group.9 Subjects were from the general public and self-referred when the screening was made available at local senior centers, living facilities, and health fairs. The original study was conducted to increase access to BMD testing in the elderly population. Bone mineral density testing and counRohr et al Original Contribution.

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Biodiesel to be used as a diesel fuel additive lubricity improver ; . Last but not least, many lorry and car manufacturers are beginning to accept and hence to provide the necessary warranty ; biodiesel as a pure fuel or in blends with standard diesel fuel. Despite this optimistic future, many barriers still limit biodiesel diffusion: - high prices for raw materials vegetable oils - price instability over time; - continuously changing price differences between vegetable and mineral oils. According to the Austrian Biofuel Institute current world biodiesel production is based: - 84% on rapeseed oil; - 13% on sunflower oil; - 1% on soybean oil; - 1% on palm oil; - the remaining 1% on miscellaneous oils. Apart from price, which is the major driving force for the success of a vegetable oil for biodiesel production, the specific fatty acid composition of each fatty substance must also be taken into account. Table 1 lists the main relationships between fatty acid composition and biodiesel properties. An additional and very important barrier for further biodiesel development is glycerol. Glycerol is a non-voluntary by-product of biodiesel production, producing a yield of approx. 10% of processed oil, biodiesel being produced in a 100% yield. Table 2 reports the 20 year evolution in glycerol prices Claude et al., 2000 ; . Between 1979 and 1999, with some temporary variations, the bulk price of refined glycerol did not change in absolute value. In addition, increasing amounts of glycerol coming from biodiesel production is expected to reduce the price even further. Annual world glycerol consumption remained constant during recent years at around 600, 000 tonnes per year, split into several possible applications such as: - cosmetics, soaps, pharmaceuticals 26% - alkyd resins 6.

Ackground: Depression is highly prevalent among persons with chronic medical conditions and is associated with increased physical and social disability. The prevalence of depression is particularly high among persons with multiple sclerosis MS ; : 41% of communitydwelling persons endorse clinically significant depressive symptoms. 1 ; The relationships among depression, disability, and severity of illness in MS are not well understood. Method: A survey was mailed to 1, 347 members of the Eastern Washington State MS Association. 535 subjects returned the survey, for a response rate of 40%. Data were collected about demographics and employment, and history of MS confirmation of diagnosis, duration and course of illness ; . Severity of illness was determined by a selfreport version of the Expanded Disability Status Scale. Disability was evaluated by the 12-item WHO DAS II, a new general disability instrument; and severity of depressive symptoms was evaluated with the Center for Epidemiologic Studies Depression Scale CES-D Scale ; . Linear regression was used to identify variables associated with significant disability. Results: Subjects had a mean WHO DAS II score of 40.7 SD 24.7 ; , reflecting moderate disability. Forty-seven percent of the subjects had significant depressive symptoms CES-D Scale score 16 ; , and 32% of subjects appeared moderately to severely depressed CES-D Scale score 21 ; . After controlling for severity of MS Expanded Disability Status Scale score ; , subjects with clinically significant depressive symptoms were much more likely to experience significant disability than subjects without depression v2 14.18, df 1, p 0.0001 ; . CES-D Scale score 16 was associated with a 21.0-point higher WHO DAS II score. The best linear regression. 3. Roberts JN, Lei HH, Krishen A, et al. Identifying subscales of the 31-item Hamilton Depression Scale. Poster presented at the New Clinical Drug Evaluation Unit NCDEU ; meeting, May 28-31, 2001, Phoenix, AZ. 4. Riskind JH, Beck AT, Brown G, Steer RA. Taking the measure of anxiety and depression: validity of the reconstructed Hamilton scales. J Nerv Ment Dis. 1987; 175: 474-479. Fleck NPA, Poirier-Littre MF, Guieli JD, et al. Factorial structure of the 17-item Hamilton Depression Rating Scale. Acta Psychiatr Scand. 1995; 92: 168-172. Salamero MT, Factor study of the Hamilton Rating Scale for Depression and the Bech Melancholia Scale. Acta Psychiatr Scand. 1990; 82: 178-181. Thase ME, Carpenter L, Kupfer DJ, Frank E. Clinical significance of reversed vegetative subtypes of recurrent major depression. Psychopharmacol Bull. 1991; 27: 17-22. Cattell RB. The scree test for the number of factors. Multivariate Behavioral Research. 1966; 1: 245-276. Kaiser HF. The application of electronic computers to factor analysis. Educational and Psychological Measurement. 1960; 20: 141-151. Ramos-Brioeva JA, Cordero-Villafafilia A. A new validation of the Hamilton Rating Scale for Depression. J Psychiatr Res. 1988; 22: 21-8. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960; 23: 56-62. Williams JB. Standardizing the Hamilton Depression Rating Scale: past present and future. Eur Arch Psychiatry Clin Neurosci. 2001; 251 Suppl 2 ; : II6-II12. 13. Sotsky SM, Simmens SJ. Pharmacotherapy response and diagnostic validity in atypical depression. J Affect Disord. 1999; 54: 237-247. Trivedi MH, Rush AJ, Carmody TJ, et al. Do bupropion SR and sertraline differ in their effects on anxiety in depressed patients? J Clin Psychiatry. 2001; 62: 776-81. Flumazenil Romazicon ; is a competitive benzodiazepine antagonist that is used to reverse benzodiazepine-induced conscious sedation following a medical procedure. Controversy exists over its use to reverse the CNS depression associated with an intentional overdose of a benzodiazepine. Seizures, dysrhythmias, and benzodiazepine withdrawal have occurred in patients who are benzodiazepine-dependent or who coingest drugs that are capable of inducing seizures or dysrhythmias. Many drugs fall into this category, including tricyclic antidepressants, theophylline, carbamazepine, bupropion, chloral hydrate, chloroquine, cocaine, isoniazid, propoxyphene, meperidine and others. The. The CSM has issued a reminder that bupropion is contra-indicated in patients with a history of seizures or of eating disorders, a CNS tremor, or who are experiencing acute symptoms of benzodiazepine withdrawal. Bupropion should not be prescribed to patients with other risk factors for seizures unless the potential benefit of smoking cessation clearly outweighs the risk. Factors that increase the risk of seizures include concomitant administration of drugs that can lower the seizure threshold anti-depressants, antimalarials, antipsychotics, quinolones, sedating antihistamines, systemic corticosteroids, theophylline, tramadol ; , alcohol abuse, history of head trauma, diabetes, and use of stimulants and anorectics. Other drug s ; may interact with bupropion zyban ; other medicines that can interact with bupropion include: • alcohol • amphetamine • carbamazepine • cimetidine • medications or herbal products for weight control or appetite • medicines for mental depression, emotional, or psychotic disturbances • medicines for difficulty sleeping • medicines called mao inhibitors-phenelzine nardil® , tranylcypromine parnate® , isocarboxazid marplan® , and selegiline eldepryl® • ritonavir • some medicines for heart rhythm or blood pressure • some medicines for migraine headache propranolol ; • cocaine • corticosteroids • dextroamphetamine • doxercalciferol • kava kava, piper methysticum • levodopa or combination drugs containing levodopa • linezolid • some medicines for pain, such as codeine • st.