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Table 3.1. Pharmaceutical expenditure in EU member states 1980-2003. Our first speaker, Jonathan Wooley, who will focus on the U.S. side, is corporate vice president and actuary for New York Life Insurance Company. In his 32 years with New York Life, he's been involved with virtually all actuarial aspects of life and annuity operations, including pricing, financial, and asset adequacy types of work. He's been very active in Academy work groups, including membership in the Academy's Variable Annuity Guaranteed Living Benefit VAGLB ; Work Group. He is also a member of the Academy's Committee on Life Insurance Financial Reporting, and in the past he has participated in other Academy and industry groups, including groups on nonforfeiture, disclosure, and annuity valuation. Thus he certainly is well qualified to discuss the topic at hand. He also has acted as associate editor of The Actuary and editor of various transactions. Mr. Jonathan L. Wooley: The interim report of the VAGLB Work Group that the Academy has put together has much good reading. The work group issues reports to the Life and Health Actuarial Task Force LHATF ; of the NAIC. There is much good reading there. I think it's 50-odd pages, with lots of technical analysis, so if you want to get into the reserving issues, you can certainly do that. As you probably all know, the benefits--certainly in the U.S. for death and the more recent living benefits--have been accelerating in their variety of designs. With that, let me get into the guaranteed benefit valuation issues in the U.S. market. I'll quickly go through just a few definitions, as you may have seen these a few times before. The guaranteed minimum death benefit GMDB ; , obviously, guarantees a minimum pay-out on death and was traditionally for many, many years just the return of premium. But now, in the last few years, the guaranteed amount can be the net contributions accumulated with or without interest, or the anniversary account value reset every one to three years. These are typically called roll-up benefits, wherein you accumulate interest, do not accumulate interest, or ratchet the benefits when you retrospectively look back every one to three years. They're offered with or without specific charge. Some companies have these as riders. Actually the riders are offered more with the living benefits, but I think some companies like to have a menu of death benefits that give the policyholder the option of paying extra for the more valuable benefit. A variation of this has happened in recent years. It was the GMDB mutual fund wrapper. This benefit has been underwritten by a few insurers for a few mutual funds and they're similar benefits to what you would find in the VA contracts. From what I've seen--and again, it's a quickly moving market--they're offered at a specific additional charge of 2030 basis points. One of the more recent benefits is under the living benefit category, the guaranteed minimum accumulation benefit GMAB ; . It provides returns of net contributions with or without interest, typically after 812 years, on some or all of the VA subaccounts, including the fixed account. We find that the most current ones are the roll-up benefits. We haven't seen a ratchet benefit yet on the accumulation side, but it may very well be coming. It's offered as a rider with a separate cost, of course, or integrated with the base policy, in which case there may or may not be a separate cost.

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If possible, analyze mutations on several backgrounds. If the mutation is maintained on a mixed genetic background, analyze it in hybrids of the two progenitor strains Silver 1995; Linder 2001, 2006 ; . Consider the effects of environmental factors such as noise, light, home cage environment, handling, and diet on gene expression and behavior Crawley et al. 1997; Bailey et al. 2006 ; . In all your research communications, describe your mouse models with correct nomenclature Linder 2006 ; . In summary, the importance of considering the genetic backgrounds of mouse models used in biomedical research cannot be overemphasized. If that research is to be reliable and reproducible over time and place, and, more importantly, if it is to have the most potential for improving human health, it must be conducted with models whose genetic backgrounds are welldefined, stable, and clearly communicated and domperidone.

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For obtaining fascia for interposition, see 20920-20922 ; For prosthetic replacement arthroplasty, see 25441-25446 ; 25335 25337 Centralization of wrist on ulna eg, radial club hand ; Reconstruction for stabilization of unstable distal ulna or distal radioulnar joint, secondary by soft tissue stabilization eg, tendon transfer, tendon graft or weave, or tenodesis ; with or without open reduction of distal radioulnar joint Osteotomy, radius; distal third middle or proximal third Osteotomy; ulna radius AND ulna Multiple osteotomies, with realignment on intramedullary rod Sofield type procedure radius OR ulna radius AND ulna Osteoplasty, radius OR ulna; shortening lengthening with autograft Osteoplasty, radius AND ulna; shortening excluding 64876 ; lengthening with autograft Osteoplasty, carpal bone, shortening Repair of nonunion or malunion, radius OR ulna; without graft eg, compression technique ; with autograft includes obtaining graft ; Repair of nonunion or malunion, radius AND ulna; without graft eg, compression technique ; with autograft includes obtaining graft ; Repair of defect with autograft; radius OR ulna radius AND ulna Insertion of vascular pedicle into carpal bone eg, Hori procedure ; Repair of nonunion of carpal bone excluding carpal scaphoid navicular includes obtaining graft and necessary fixation ; , each bone Repair of nonunion, scaphoid carpal navicular ; bone, with or without radial styloidectomy includes obtaining graft and necessary fixation ; 250.00 206.00 120 + T 3.0 + T. Several treatment modalites are currently in research to help diabetic patients, including whole pancreas transplantation. In the past, this procedure was unsuccessful because of limitations in pancreatic islet isolation and graft survival, but technological advances in specific immunomodulation offer new hope. If whole pancreas transplantation does not work, studies are also underway on islet transplantation. New drug therapies include a glucagonlike peptide 1, a potent insulin secretagogue. Inhaled insulin and additional insulin analogues are also in advanced stages of clinical trials. Studies are being done on aminoguanidine, an inhibitor of the formation of advanced glycosylation end products, and inhibitors of protein kinase C both of which may reduce the complications of DM. Lastly, advances in continuous glucose monitoring technology may lead to the development of closed-loop pumps, which automatically infuse the appropriate amount of insulin in response to changing glucose levels and propulsid. 371. Whiteneck GG, Charlifue SW, Gerhart KA, et al. Quantifying handicap: a new measure of long term rehabilitation outcomes. Arch Phys Med Rehabil 1992; 73 6 ; : 519-26. 372. Miller B, Rosenthal M, Kreuzer JS, et al. Assessment of community integration following rehabilitation for traumatic brain injury. J Head Trauma Rehabil 1993; 8 2 ; : 75-87. 373. Kalman TP. An overview of patient satisfaction with psychiatric treatment. Hosp Commun Psychiatry 1983; 34: 48-54. Perrault M, Leichner P, Sabourn S, Gendreau P. Patient satisfaction with outpatient psychiatric services. Eval Prog Plan 1993; 16: 109-18. Greenley JR, Schulz R, Nam SH, Peterson RW. Patient satisfaction with psychiatric inpatient care: issues in measurement and application. Res Commun Mental Health 1985; 5: 303-19. Lasker JN, Toedter LJ. Satisfaction with hospital care and intervention after pregnancy loss. Death Studies 1994; 18: 41-64. Lebow JL. Similarity and differences between mental health and health care evaluation studies assessing consumer satisfaction. Eval Prog Planning 1983; 6: 237-45. Larsen DL, Attkisson CC, Hargreaves WA, Nguyen TD. Assessment of client patient satisfaction: development of a general scale. Eval Prog Planning 1979; 2: 197-207. FY 2004 Accomplishments: Developed a portable, automated tester for walk-through metal detectors to validate compliance with the National Institute of Standards and Technology test standard. Operationally tested an advanced entry-point vehicle driver identification system. Developed and fielded an enhanced expeditionary version. Evaluated a commercial, automated, under-vehicle inspection system. Published inspection screening guides for screening rail cars and personnel for explosives or other contraband at entry points. Developed and field tested a lightweight, portable boom and underwater swimmer detection system to protect ships in port. Conducted a proof-of-concept test for a perimeter intrusion detection system using airport ground surveillance radar. Developed a wireless tactical video surveillance system for perimeter intrusion detection. Evaluated commercial smart video systems for detection and assessment of possible vehicle bomb threats. Operationally tested a long-range, optical, intrusion detection, tracking, and assessment system. Evaluated badging technologies for credentialing government employees, contractors, and visitors entering government facilities. Tested on redesigned and or retrofitted structural and non-structural building components for blast effects from enhanced explosive mixtures. Delivered a simulation and prediction blast injury code for secondary debris field injuries. Developed, tested, and deployed a light, low-cost retrofit polymer armor solution for tactical vehicles that can be applied in the field. Developed a database to archive blast test data and make it easily accessible to government and military planners and engineers. Improved structural design models and validated modeling simulations by performing blast tests on columns and other structural and nonstructural components using conventional high explosives and enhanced novel explosives. Performed dynamic testing of commercialoff-the-shelf blast resistant retrofit products. Characterized and calibrated a blast simulator that mimics the effects of enhanced novel explosives and conventional explosives at varying standoff distances and blast strengths. Deployed two web based information library portals that provide historical and on-going reports and research and development information on human lethality in a blast environment as well as blast effects and mitigation. UNCLASSIFIED R-1 Shopping List Item No. 27 Page 7 of 14 and clemastine.
Determining the duration of a patient's insomnia is your first step when considering treatment. Acute insomnia lasts from one night to a few weeks. It is often a sign of physical or emotional discomfort and may require treatment if sleep difficulties persist or become predictable. Chronic insomnia occurs at least three nights a week for a month or more. A medical condition or mood anxiety disorder is more likely to cause chronic insomnia. The active substance and metabolites are eliminated completely, two thirds of an oral administered dose with the urine, one third with the faeces. Following inhalation of formoterol, a mean of 6 % to the substance is eliminated unchanged with the urine. Renal clearance of formoterol is 150 ml per minute. 5.3 Preclinical safety data The effects of formoterol seen in toxicity studies in rats and dogs were mainly on the cardiovascular system and consisted of hyperaemia, tachycardia, arrhythmias and myocardial lesions. These effects are known pharmacological manifestations seen after the administration of high doses of 2-agonists. A somewhat reduced fertility in male rats was observed at very high systemic exposure of formoterol. No genotoxic effects of formoterol have been observed in in-vitro or in-vivo tests. In rats and mice, a slight increase in the incidence of benign uterine leiomyomas has been observed. This effect is looked upon as a class effect in rodents after long exposure to high doses of 2-agonists and clopidogrel.

These drugs act to reduce the levels of estrogen in your body. Atuss MR syrup - 4 oz Atuss MS syrup - 6 oz Extendryl 10-2-1.2 Chw - 100 tabs Tussi-12 S susp Tussi-Bid 1200-60M tabs Tussionex and cloxacillin. As medicine but from industrial competition. As long as firms are committed to producing medications to treat diseases--as they are classified by medical science--this argument has some authority. But once a firm becomes principally driven by marketing--the case for most companies in most industries since the 1980s--then innovation comes to mean an elaboration of meaningless differences among a field of comparable "me too" products. "If marketing is seminally about anything, " said Theodore Levitt, one of the towering figures of marketing and former editor of the Harvard Business Review, " it is about achieving customer-getting. 366. STICH, V.; DE GLISEZINSKI, I.; GALITZKY, J.; HEJNOV, J.; CRAMPES, F.; RIVIERE, D.; BERLAN, M.: Endurance training increases the beta adrenergic lipolytic response in subcutaneous adipose tissue in obese subjects. International Journal of Obesity and Related Metabolic Disorders, 1999, roc. 23, 4 ; , s. 374-379. Cslo VZ: MSM 111200001, Cslo grantu: IZ3611, [pvodn]. IF: 3, 119 99 TACHEZY, R.; HAVRNKOV, A. a kol.: Human papilomavirus Genotype spectrum in Czech women: correlation of HPV DNA Presence with antibodies HPV - 16, 18 and 33 virus - like particles. Journal of Medical Virology, 1999, roc. 58, 4 ; , s. 378-386. [pvodn]. IF: 2, 867 99 URBAN, P.; LUKS, E.; NERUDOV, J.; CBELKOV, Z.; CIKRT, M.: Neurological and electrophysiological examinations on three groups of workers with diferent levels of exposure to mercury vapors. European Journal of Neurology, 1999, roc. 6, 5 ; , s. 571-577. [pvodn]. IF: 0, 670 99 369. ZATLOUKAL, P.: Non-small cell lung cancer: report on 5th Central European Lung. Biomedicine and Pharmacotherapy, 1999, roc. 53, 3 ; , s. 154-162. Cslo grantu: : NJ4970, [pvodn]. IF: 0, 852 99 370. ALPINI, D.; CAPUTO, D.; HAHN, A.; PUGNETTI, L.; MONTI, B.; RAZZARI, S.; CESARANI, A.: Grading Brainstem Involvement in Multiple Sclerosis by Means of Electro-oculography . Journal of NeuroVirology, 2000, roc. 6, Suppl. 2 ; , s.156-159. [pvodn]. IF: 3, 397 00 371. ARENBERGER, P.; BROZ, L.; VESEL, P.; HAVLCKOV, B.; MATOUSKOV, E.: Tissue-engineered Skin in the Treatment of Vitiligo Lesions. Folia Biologica, 2000, roc. 46, 3 ; , s.157-160. Cslo grantu: : NK6126, IZ4368, [pvodn]. IF: 0, 351 00 372. BARTOS, A.; RUSINA, R.: Centrln pontinn myelinolza v klinicko-neuroanatomickch souvislostech. Central Pontine Myelinolysis-Clinical and Neuroanatomical Considerations ; . Cesk a slovensk neurologie a neurochirurgie, 2000, roc. 63 96, 6 ; , s.422-425. [kazuistika]. IF: 0, 059 00 373. BARTOS, A.; SACH, J.; JANOUSKOV, L.; JIRSEK, A.: Gliomatosis cerebri-stle zrdn diagnza. Gliomatosis Cerebri-still a Treacherous Diagnosis ; . Cesk a slovensk neurologie a neurochirurgie, 2000, roc. 63 96, 3 ; , s.185-188. [pvodn]. IF: 0, 059 00 374. BENOIST, P.; FEAU, P.; PLISS, A.; VOSEK, J.; ANTONELLI, R.; RASKA, I.; DENIS, D.M.: The yeast Ura2 protein that catalyses the first two steps of pyrimidines biosynthesis accumulates not in the nucleus but in the cytoplasm, as shown by immunocytochemistry and Ura2-green fluorescent protein mapping. Yeast, 2000, roc. 16, s.14 ; , s.1299-1312. [pvodn]. IF: 2, 825 00 375. BERNSKOV, K.; MARES, P.: Proconvulsant Effect of Aminophylline on Cortical Epilaptic Afterdischarges Varies during Ontogeny. Epilepsy Research, 2000, roc. 39, 3 ; , s.183-190. Cslo grantu: : IZ2209, IZ3510, [pvodn]. IF: 2, 866 00 376. CELKO, A.M.; BROZ, L.; DOV, J.; KZ, B.: Analysis of Pediatrics Burns in the Prague Burns Centre. Epidemiology, 2000, roc. 11, Suppl. ; , s.85. Cslo grantu: : NJ4666, [pvodn]. IF: 3, 632 00 377. CELKO, A.M.; BROZ, L.; DOV, J.; KZ, B.; HIVNA, M.: Analysis of Pediatric Burns in the Prague Burns Centre 1995-1998. Epidemiology, 2000, roc. 11, 4 ; , s.87. [pehledov]. IF: 3, 632 00 378. CELKO, A.M.; VANCEK, K.; DOV, J.: Total ozone depletion and melanoma of the skin in Czech Republic 19701997. Epidemiology, 2000, roc. 11, 4 ; , s.87. [pehledov]. IF: 3, 632 00 379. DJABORKHEL, R.A.; TVRDK, D.; ECKSCHLAGER, T.; RASKA, I.; MLLER, J.: Cyclin a down-regulation in TGF beta 1-arrested follicular lymphoma cells. Experimental Cell Research, 2000, roc. 261, 1 ; , s.250-259. [pvodn]. IF: 3, 860 00 380. DUSKOV, M.; KOZK, J.; MAZNEK, J.; SMAHEL, Z.; VOHRADNK, M.: Augmentation of Facial Skeleton in Congenital Development Disorders and in Posttraumatic or Postoperative Deformities preliminary report ; . European Journal of Plastic Surgery, 2000, roc. 23, 2 ; , s.57-63. Cslo grantu: : NK4659, [pvodn]. IF: 0, 159 00 381. DUSKOV, M.; SMAHEL, Z.; MAZNEK, J.; VOHRADNK, M.; KOZK, J.: Bioactive Glass-ceramics in Facial Skeleton Contouring final report-part I ; . Journal of Craniofacial Surgery, 2000, roc. 11, 5 ; , s.470-479. Cslo grantu: : NK4659, [pvodn]. IF 0, 541 00 382. ELTSOV, M.; GRANDI, P.; RASKA, I.: Ultrastructural characterization of RPA-containing domains in nuclei assembled in Xenopus egg extracts. Journal of Structural Biology, 2000, roc. 129, 2-3 ; , s.211-7. [pvodn]. IF: 3, 255 00 383. GALVEZ, T.; PRZEAU, L.; MILIOTI, G.; FRANK, M.; JOLY, C.; FROESTL, W.; BETTLER, B.; BERTRAND, H.-O.; BLAHOS, J.; PIN, J.-P.: Mapping the agonist-binding site of GABAB type 1 subunit sheds light on the activation process of GABAB receptors. Journal of Biological Chemistry, 2000, roc. 275, 52 ; , s.41166-41174. [pvodn]. IF: 7, 368 00 384. HADAC, J.; VYSATA, O.; HOVORKA, J.; ZRUBOV, J.: Diplov analza u pacient s temporln epilepsi-kandidt epileptochirurgick lcby. Dipole Analysis in Patients with Temporal Epilepsy-Candidates of Epileptosurgical Treatment ; . Cesk a slovensk neurologie a neurochirurgie, 2000, roc. 63 96, 2 ; , s.86-91. Cslo grantu: : IZ4328, [pvodn]. IF: 0, 059 00 385. HAINER, V.; STUNKARD, A.; KUNESOV, M.; PAZKOV, J.; STICH, V.; ALLISON, J.: Intrapair Resemblance in Very Low Calorie-induced Weight Loss in Female Obese Identical Twins. International Journal of Obesity and Related Metabolic Disorders, 2000, roc. 24, 8 ; , s.1051-1057. Cslo VZ: MSM 111200001, [pvodn]. IF: 2, 982 00 and cromolyn. 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Turvey SE, Swart E, Denis MC, Mahmood U, Benoist C, Weissleder R, Mathis D Section on Immunology and Immunogenetics, Joslin Diabetes Center, and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass., USA J Clin Invest 2005; 115: 24542461 and danocrine. 5 -GTTTCCATATGGGGATTGG-3 5 -CCAGACCAACTGGTAATGG-3 5 -AAAAGATCTGTCGACCCCCCCCCCCCCCC-3 and photolysis was performed for 30 min at 4 C. The sample was then precipitated with 20 C high performance liquid chromatography grade acetone, centrifuged at 5900 g for 5 min at 4 C, and the protein pellet was resuspended in 75 l urea sample buffer that contained 5 l of creatine phosphokinase carbamylation standard Pharmacia ; prior to the subsequent isoelectric focusing step. This preparation was used to perform isoelectric focussing for 15 h at 750 V as described by O'Farrell 18 ; . The isoelectric focusing tube gel was then placed on a 15% polyacrylamide-SDS gel, and electrophoresis was performed in the second dimension. The resulting gel was either stained with Coomassie Blue and photographed Fig. 2C ; , or was treated with the autoradiogram enhancer RESOLUTIONTM EM Corp, Chestnut Hill, MA ; and was dried prior to autoradiography Fig. 2D ; . In some cases, gels were stained with the method of Rosenfeld et al. 19 ; prior to proteolytic digestion and partial N-terminal amino acid sequencing which was performed in the Mayo Research Resource Protein Core Laboratory. Rabbit Lung INMT cDNA Cloning--The strategy used to clone a rabbit lung INMT cDNA is depicted schematically in Fig. 3. Rabbit lung INMT amino acid sequences PEAEMLK and RNREELA were used to design degenerate forward DF1 ; and reverse DR1 ; primers for the PCR, respectively Fig. 3, Step 1 ; . The sequences of these and other oligonucleotide primers described subsequently are listed in Table I.
This can be given as a liquid or as a tablet and ddavp and cinnarizine. Andrea A. Thornton, Ph.D., 1 Lisa Madlensky, Ph.D., 2 and For the WHEL Study Group.2 of Supportive Care, Pain, and Palliative Medicine, City of Hope National Medical Center, Duarte, CA; and 2Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA. Being diagnosed with breast cancer for a second time is widely perceived to have a profound negative impact on quality of life QOL ; . Using the Rand 36-Item Health Survey, we present prospective data obtained from a subsample of women n 140 ; participating in the Women's Healthy Eating and Living WHEL ; Study who experienced breast cancer recurrence or a new primary breast cancer NP ; to clarify the impact of diagnosis on QOL. Our sample experienced significant decrements in Physical Functioning, Physical Role Limitations, Pain, General Health Perception, Energy, and Social Functioning, but not Emotional Wellbeing or Emotional Role Limitations. Comparing women with local recurrence LR ; , distant metastatic recurrence DR ; and NP disease, we found that DR patients reported a worse decline in general health perception compared to LR patients mean decline of 19.9 points vs. 6.4; p 0.001 ; . We identified important sources of response bias: DR women had higher death rates 28% vs 4% LR and 6% NP ; after agreeing to, but before completing the post-recurrence QOL assessment. The DR women were also more likely to refuse a post-recurrence QOL assessment 27% refusal rate vs. 14% LR and 13% NP ; , suggesting that patients with distant recurrence may be underrepresented in research examining the impact of recurrence on QOL. Thus, existing data on breast cancer recurrence is likely biased toward healthier women, and may not adequately capture the true impact of recurrence on QOL. CORRESPONDING AUTHOR: Andrea A. Thornton, PhD, Supportive Care, Pain, and Palliative Medicine, City of Hope National Medical Center, 1500 E. Duarte Rd, Duarte, CA, USA, 91010; athornton coh.

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Meige H, Feindel EC. Tics and their treatment. London: Appleton; 1907. Mezaki T, Kaji R, Kohara N, Kimura J. Development of general weakness in a patient with amyotrophic lateral sclerosis after focal botulinum toxin injection. Neurology 1996; 46: 8456. Micheli F, Pardal MF, Gatto M, Torres M, Paradiso G, Parera IC, et al. Flunarizine- and cinnarizine-induced extrapyramidal reactions. Neurology 1987; 37: 8814. Mitchell SW. Injuries of nerves and their consequences. Philadelphia: J.B. Lippincott; 1872. Molho ES, Factor SA. Basal ganglia infarction as a possible cause of cervical dystonia. Mov Disord 1993; 8: 2136. Moore AP, Blumhardt LD. A double blind trial of botulinum toxin `A' in torticollis, with one year follow up. J Neurol Neurosurg Psychiatry 1991; 54: 8136. Naumann M, Becker G, Toyka KV, Supprian T, Reiners K. Lenticular nucleus lesion in idiopathic dystonia detected by transcranial sonography. Neurology 1996; 47: 128490. Nutt JG, Muenter MD, Aronson A, Kurland LT, Melton LJ 3d. Epidemiology of focal and generalized dystonia in Rochester, Minnesota. Mov Disord 1988; 3: 18894. Obeso JA, Rothwell JC, Lang AE, Marsden CD. Myoclonic dystonia. Neurology 1983; 33: 82530. Ozelius L, Kramer PL, Moskowitz CB, Kwiatkowski DJ, Brin MF, Bressman SB, et al. Human gene for torsion dystonia located on chromosome 9q32q34. Neuron 1989; 2: 142734. Panizza M, Lelli S, Nilsson J, Hallett M. H-reflex recovery curve and reciprocal inhibition of H-reflex in different kinds of dystonia. Neurology 1990; 40: 8248. Pascual-Leone A, Cammarota A, Wassermann EM, Brasil-Neto JP, Cohen LG, Hallett M. Modulation of motor cortical outputs to the reading hand of braille readers. Ann Neurol 1993; 34: 337. Patterson RM, Little SC. Spasmodic torticollis. J Nerv Ment Dis 1943; 98: 57199. Pearce LB, Borodic GE, Johnson EA, First ER, MacCallum R. The median paralysis unit: a more pharmacologically relevant unit of biologic activity for botulinum toxin. Toxicon 1995; 33: 21727. Poewe W, Wissel J. Experience with botulinum toxin in cervical dystonia. In: Jankovic J, Hallett M, editors. Therapy with botulinum toxin. New York: Marcel Dekker; 1994. p. 21137. Rivest J, Marsden CD. Trunk and head tremor as isolated manifestations of dystonia [see comments]. Mov Disord 1990; 5: 605. Comment in: Mov Disord 1990; 5: 3534. Rondot P, Marchand MP, Dellatolas G. Spasmodic torticollis review of 220 patients. Can J Neurol Sci 1991; 18: 14351. Schiavo G, Rossetto O, Catsicas S, Polverino de Laureto P, DasGupta BR, Benfenati F, et al. Identification of the nerve terminal targets of botulinum neurotoxin serotypes A, D, and E. J Biol Chem 1993a; 268: 237847. Schiavo G, Shone CC, Rossetto O, Alexander FC, Montecucco C. Botulinum neurotoxin serotype F is a zinc endopeptidase specific for VAMP synaptobrevin. J Biol Chem 1993b; 268: 115169. This material contains an active pharmaceutical ingredient that is likely to undergo photodegradation. UV Visible Spectrum: 290 nm This material contains an active pharmaceutical ingredient that is not readily biodegradable but is inherently biodegradable as defined by 1993 OECD Testing Guidelines ; and is not expected to persist in the environment. Aerobic - Ready Percent Degradation: 42 %, 64 days, Modified Sturm test. Percent Degradation: 28 %, 28 days, Modified Sturm test. Aerobic - Inherent Percent Degradation: 74 %, 1 day, Modified Zahn-Wellens, primary biodegradation, loss of parent., Activated sludge Aerobic - Soil Percent Degradation: 42.8 to 80 %, 64 days Page 5 6. Most of the adverse events occurred in those patients who had pre-existing medical conditions or were taking other medications.