TEVA PHARMACEUTICAL INDUSTRIES LIMITED NOTES TO CONSOLIDATED FINANCIAL STATEMENTS continued ; NOTE 1 - SIGNIFICANT ACCOUNTING POLICIES continued ; : s. Stock-based compensation: The Company accounts for its employee stock option plans using the intrinsic value based method of accounting prescribed by APB 25, "Accounting for Stock Issued to Employees" and related interpretations. Accordingly, the compensation cost relating to stock options is charged on the date of grant of such options, to shareholders' equity, under deferred compensation, and is thereafter amortized by the straight-line method and charged against income over the vesting period. FAS 123, "Accounting for Stock-Based Compensation, " as amended by FAS 148, established a fair value based method of accounting for employee stock options or similar equity instruments. However, it also allows companies to continue to account for those plans using the accounting treatment prescribed by APB 25. The Company has elected to continue accounting for employee stock option plans according to APB 25, and has accordingly complied with the disclosure requirements set forth in FAS 123, for companies electing to apply APB 25. The following table illustrates the effect on net income and earnings per ADR, assuming the Company had applied the fair value recognition provisions of FAS 123 to its stock-based employee compensation.
If resident is now free of psychotropic drugs as a result of the drug reduction program, he she may continue to be scored a Level 2. The monthly progress note should address symptoms alternate behavior interventions as well as resident response to the program. Credit should be given on Level 2 for self- medication when the program includes teaching the steps which lead to increased resident independent with regard to medications, i.e., the resident knowing the times of different medications, identifying the correct medication by sight and by purpose or name, knowing side effects to report to the doctor or nurse, physically taking the medication, etc. Psychotropic medications shall not be administered for purposes of discipline or staff convenience and when not required to treat the resident's medical symptoms. To qualify for a psychotropic drug program Level 2 ; , at least the following elements must be in place.
Activity, heavy lifting, or more intensive exercise programs. Check with your coordinator and physician for your center's guidelines. The best activity in the first few weeks after transplant is walking. Most centers recommend that any activities or sports with a high risk of injury like football, wrestling, skiing, water skiing, or motorcycling, should be avoided for at least one year after transplant. Some centers restrict contact sports indefinitely. To be healthy and fit is an important goal, but using common sense to reach this goal is just as important. Even months or years after your transplant, exercising when you are sick with a fever is not a good idea. If you ever experience any intense pain, chest pain, or shortness of breath while exercising, you should stop exercising immediately and seek medical attention or advice.
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Pharmacies and health clinics may dispense Plan BTM without a prescription if there is a "healthcare provider" on site. Clinicians are urged to dispense Plan BTM and or oral contraceptives directly to their patients from their office. A provider can directly dispense Plan BTM anywhere she or he has prescribing authority for those under 18 years with no restrictions for those over 18 years.14 Evidence shows that the patients are more likely to take ECPs if they receive them in advance.15!
Clearly the drug companies are in a precarious position when they agree to offer discounts or permit compulsory licensing or parallel importing of drugs only for certain populations or for certain diseases. Said Alan Murray in a March 2001 Wall Street Journal op-ed piece, the pharmaceutical companies "correctly see the camel's nose nuzzling into their gold-trimmed tents and myambutol.
U.S. Patent No. 6, 262, 071 granted July 17, 2001, relating to methods of using antimicrobial compounds against pathogenic Mycoplasma bacteria; licensed from LG Life Sciences; expiring September 21, 2019; -- U.S. Patent No. 6, 331, 550 granted December 18, 2001, relating to methods of using of quinolone compounds against anaerobic pathogenic bacteria; licensed from LG Life Sciences; expiring September 21, 2019; -- U.S. Patent No. 6, 455, 540 granted September 24, 2002, relating to methods of use of quinolone compounds against anaerobic pathogenic bacteria; licensed from LG Life Sciences; expiring September 21, 2019; -- U.S. Patent No. 6, 723, 734 granted April 20, 2004, relating to the salt of naphythyridine carboxylic acid derivative; licensed from LG Life Science; expiring March 20, 2018. -- U.S. Patent No. 6, 803, 376 granted October 12, 2004, relating to methods of use of quinolone compounds against pneumococcal pathogenic bacteria; licensed from LG Life Science; expiring September 21, 2019. We are not currently involved in any litigation, settlement negotiations, or other legal action regarding patent issues and we are not aware of any patent litigation threatened against us. Our patent position involves complex legal and factual questions, and legal standards relating to the validity and scope of claims in the applicable technology fields are still evolving. Therefore, the degree of future protection for our proprietary rights is uncertain. Under our license agreement with LG Life Sciences, we obtained an exclusive license to develop and market gemifloxacin in certain territories. This license covers 18 issued U.S. patents and a broad portfolio of corresponding foreign patents and pending patent applications. These patents include claims that relate to the chemical composition of FACTIVE, methods of manufacturing and its use for the prophylaxis and treatment of bacterial infections. The U.S. patents are currently set to expire at various dates, ranging from 2018, in the case of the principal patents relating to FACTIVE tablets, to 2019. We have filed a patent term extension application covering the regulatory review process for one of the principal patents, U.S. Patent 5, 776, 944, expiring in 2015. If granted, this extension would extend the exclusivity period through 2017. We also have the exclusive right to use FACTIVE trademarks, trade names, domain names and logos in conjunction with the use or sale of the product in the territories covered by the license. LG Life Sciences, as owner of U.S. Patent Nos. 5, 776, 944 and 5, 962, 468, submitted requests for reexamination to the U.S. Patent & Trademark Office, or PTO, in order to place additional references into the record of each patent. Both requests were granted by the PTO. Patents `944 and `468 have been reexamined with relatively minor modifications to the claims and confirmed patentable over the submitted references. The patents to Ramoplanin, which we recently acquired from Pfizer Inc., include claims relating to methods of manufacturing Ramoplanin as well as methods increasing the yield of the active compound. We also have applications pending relating to various novel uses of Ramoplanin. The patent covering the chemical composition of Ramoplanin has expired. To provide additional protection for Ramoplanin, we rely on proprietary know-how relating to maximizing yields in the manufacture of Ramoplanin, and intend to rely on the five years of data exclusivity under the HatchWaxman Act in the U.S. and the ten years of market exclusively in Europe available through the European Commission.
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Further, NSW Health undertakes a rigorous analysis of the viability and financial benefit of a co-location prior to final approval, and seeks to maximise the benefits offered by the private proponent through competitive tendering. NSW Health also determines if the co-location will provide services that complement those provided by public hospitals in the region. Furthermore, it prepares an assessment on the potential impact the co-location will have on the public hospital's income from private patients. NSW Health advised that it follows the staged approval process outlined in the Guidelines for Private Sector Participation in the Provision of Public Infrastructure, such as project planning and calling for proposals and short140 listing tenders, to help evaluate and approve co-locations. Nevertheless, NSW Health recognises that the current approach to assess co-locations on a case by case basis would benefit from a documented evaluation framework, and it is drafting a Circular on Co-locations to clarify the approval process and evaluation requirements for colocations. NSW Health has advised that part of the approval process could be the requirement for a preliminary feasibility study that examines the full range of costs and benefits of a co-location. The feasibility would also consider alternatives to co-location to provide health services to the community.
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Myriad of symptoms typically arises in a PC patient who undergoes androgen deprivation therapy ADT ; . Some of these occur acutely and many may improve over time, but can still be quite troublesome if not aggravating for the patient. Other symptoms develop more gradually and are subtler, but if not treated in a preventative manner, can have a negative impact upon the PC patient's overall health. Except for hot flushes and impotency, many ADS symptoms were discounted by physicians and patients as being due to "old age" or other medical problems such as arthritis or heart disease. However, this constellation of clinical and laboratory abnormalities quickly develops in younger men, or older men in otherwise good health, after ADT is initiated. This clearly suggests that these symptoms are not simply attributed to "old age" but are characteristic of what we have termed the Androgen Deprivation Syndrome ADS ; . ADS symptoms are directly or indirectly due to the significant fall in serum testosterone that occurs following orchiectomy or treatment with a LHRH agonist such as Lupron or Zoladex. In essence, men who are medically or surgically castrated undergo an accelerated and intensified form of "male menopause" which leads to the same types of symptoms in these men that are seen in women who undergo female menopause. Patients treated with combined ADT LHRH agonists or orchiectomy plus an anti-androgen such as Eulexin, Casodex, or Nilandron ; may have more severe ADS symptoms than those treated with a LHRH agonist or orchiectomy alone. A list the types of acute and chronic ADS symptoms appear in Table 2. To assess the significance of common ADS symptoms, we questioned 177 hormone-nave PC patients consecutively treated with a LHRH agonist and an antiandrogen between 1994 and 1997. We asked patients to grade the frequency and severity of ADS as absent 0 ; , occasional 1 and vepesid and eulexin.
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Kitzmiller says there is no research that suggests that consumers perceive obesity as a disease. In f a ct, most consumers are willing to take responsibility for being in the shape they are in. However, another major message coming from consumers is that most who are overwe i g ht obese don't perceive their ext ra we i health ri s k. "Research shows that a majori ty of obese or morbidly obese people tell themselves, `Yeah, I'm overweight, but I'm healthy, ' " he says. This trend is predominant in the United State s and growing in Europe, he says. People also often view their weight relative to the weight of those around them. Those who are aware of their health risks and see themselves as ove rwe i g ht have most likely been informed that they are at risk by their docto r. In this case, the traditional model of healthcare in which a physician suggests treat m e nt for an illness comes in to play, and physicians treat consumers in this population who buy into obesity as a medical condition fo r which they need treat m e nt. However, Kitzmiller says the traditional message that being overweight is a health issue is not effective with this group. "Everyone should know by now that if they eat and exe rcise smart, they will have healthier bodies, but that message appare ntly is not wo rking, " he says.
| Fetal monitoring and fetal stress testing are payable for outpatient hospital stays and to hospital-based RHCs only with revenue code B-729, Labor room delivery-other. The inpatient hospital stay is reimbursed under the hospital's DRG. To prevent repeat unintended or unwanted pregnancies, physicians are urged to include family planning services or referrals in the maternity care of the client. Genetic diagnosis and counseling is also available through Medicaid for clients suspected of having a genetic disorder for informed reproductive decision making. Refer to: "Family Planning Services" on page 21-1 for more information.
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Fice of Applied Studies detect drug trends in various age groups from the ages of 12 to 65. However, in those studies individuals are interviewed and surveyed about their past drug use over the last month. These studies are based entirely on the individuals telling the truth of their recent drug use. These annual studies are conducted on a sample population to determine drug trends. Those individuals used in the survey are considered a statistically significant number, thus representing the rest of the population. The studies are usually conducted by interviewing 1, 000 individuals and based on their results represents the entire population. The accuracy of these studies can be disputed because a margin of error is almost always applied to a sample population. The data from Forward Edge's laboratory provides a more accurate measurement of the drug's trends for a school district. The information provided by Forward Edge is scientifically proven and can be reproduced in a controlled laboratory environment. As federal funding becomes more readily available through the No Child Left Behind Act, schools will have the opportunity to expand their programs and pinpoint drug use.
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