By William Braden from The Private Sea: LSD and the Search for God 1967 William Braden On a good trip the LSD voyager may feel he has penetrated to the godhead itself. But is it really the godhead he sees? Or is it the Medusa? Before we describe what LSD does, let us first ask what it is. That is a much easier question to handle, admittedly, and it is mildly ironic that this is so. Where the mysteries of nature are concerned, the situation is usually reversed, as Bertrand Russell has pointed out in the case of electricity. Science can describe very accurately what electricity does but hasn't the foggiest notion what it really is. As for LSD, it is a synthetic drug: d-lysergic acid diethylamide tartrate, compounded from a constituent of a rye fungus known as ergot. Its general history by now is a twice-told tale and then some, so we shall be brief about it. LSD was first synthesized in 1938 by Dr. Albert Hofmann, a biochemist at the Sandoz pharmaceutical firm in Basel, Switzerland; but the scientist did not know what he had created until 1943, when he accidentally inhaled or otherwise absorbed a small amount of LSD and thus discovered the drug's curious properties. It produced uncanny distortions of space and time and hallucinations that were weird beyond belief. It also produced a state of mind in which the objective world appeared to take on a new and different meaning. These effects, and the agents which produce them, are now referred to as psychedelic -- a generic term which means "mind manifesting, " which in turn means nothing. The word has come into common usage simply because of its neutral connotation; due to the controversy involved, it is the only word so far that all sides have been willing to accept. It is used as both noun and adjective. Unlike heroin, opium, and alcohol, LSD apparently is not addictive. This means simply that prolonged use of the drug, so far as we can tell at this time, does not create a physiological craving or dependency based on changes in a subject's body chemistry--changes that are produced by liquor and junk--and there are no physiological withdrawal symptoms when use of the drug is terminated. LSD on the other hand may be psychologically habituating; but this, after all, can also be said of chewing gum and television. There are literally scores of psychedelic substances, natural and synthetic, and LSD is only one of many agents capable of producing a full-fledged psychedelic experience. Identical effects can be obtained from Indian hemp and its derivatives, including hashish; from the peyote cactus and its extract, mescaline; from a Mexican mushroom and its laboratory counterpart, psilocybin, which Dr. Hofmann synthesized in 1958. Hemp and peyote have been used as psychedelics for centuries, and mescaline was on the market before the turn of the century. LSD's uniqueness lies in the fact that it is very easy to make-- and mega-potent. According to the Food and Drug Administration, a single gram of LSD can provide up to ten thousand doses, each of them capable of producing an experience lasting up to twelve hours or longer. Scientists seized upon the drug as a tool for research and therapy, and literally thousands of technical papers have been devoted to it. Since LSD appeared to mimic some symptoms of psychosis, it offered possible insights into the sufferings of mental patients--although psychotherapists later came to doubt that it produces what was first referred to as a model psychosis. Preliminary research indicated it might be useful in the treatment of alcoholism and neurosis, and it also served to ease the anguish of terminal patients. In small doses, in controlled situations, it appeared to enhance creativity and productivity. But the public at large knew nothing of LSD until 1963, when two professors, Timothy Leary and Richard Alpert, lost their posts at Harvard University in the wake of charges that they had involved students in reckless experiments with the drug. Leary went on to become more or less the titular leader of the drug movement, in which capacity he soon ran afoul of the law, and the movement spread to campuses and cities across the country. By and large, it seemed at first to develop as a middle-class phenomenon, attracting to its ranks mainly students and intellectuals, liberal ministers, artists and professional people, as well as bearded pariahs. Official panic provoked a wave of legislation which ended or seriously hindered almost all legitimate research programs; the legislation did little or nothing to discourage the drug movement, which received its supplies from black market sources.
A new efficient method for the direct amidation of d-lysergic acid was used to prepare a variety of lysergamides. A pharmacological evaluation of these compounds, their di- and tetrahydro derivatives, and derivatives bearing substituents in the indole portion of the molecule showed that, in general, only 9, lOdihydrolysergamides of primary amines possess activity comparable to the potent emetic activity of the components of dihydroergotoxine.
ALS Indicators Decreased altered level of consciousness Hypotension systolic blood pressure 90 ; Excessive uncontrolled bleeding Pelvic fracture, bilateral femur fracture, or multi-system injury fractures High index of suspicion based on mechanism of injury ! ! BLS Indicators Single extremity fracture with stable vital signs Single joint dislocation with stable vital signs.
Mechanism s ; of Action ACE inhibitors inhibit the protease that cleaves the decapeptide angiotensin-I to form the octapeptide angiotensin-II. Because ACE also metabolizes bradykinin, ACE inhibitors increase circulating and tissue concentrations of bradykinin, which is thought to underlie the side effects of these drugs, including cough and angioedema Fig. 3 ; . ACE inhibitors have several useful actions in chronic HF. They are potent.
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If you are considering surgery, you must meet certain criteria to be an appropriate candidate. Most surgeons in the United States use the National Institutes of Health NIH ; guidelines. These guidelines are as follows.
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Includes mostly alcohol but also benzodiazepines, barbiturates, lysergic acid diethylamide LSD ; , phencyclidine PCP ; , and methylenedioxymethamphetamine MDMA ; . SOURCE: Treatment Assessment Screening Center, Arizona.
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Dear A TIME, i know that your readers have hea rd of every segulah under the sun and are tired of hearing more. However, i was rece ntly made aware of an unbelievabl e segulah with astounding results and i felt it was my duty to share it with your read ership. there is a hospitality housef a mal onit next to a hospital in rechovo t, in eretz Yisf roel, run by rav eliyahu Yeret. whe f n rav Yeret was planning the cent er he approached the Admor of Gur, the Pnei Menache m zatzal, to seek advice about rele vant halachic questions such as yichud. He men tioned that he was searching for a couple who had married off all their children and he would pay them to run the hosp itality center. The Admor however offered that there should be a roster of coup les involved, indicatt ing that that each week a new coup f le would have to be found to run the center. this sounded rather difficult to implem ent, but the Admor reassured R. Yeret, "There will be no problem." Writing out a chec k for a very large sum, the Admor clearly stated and demonstrated that he wished to be part of this great mitzvah. This was the first donation that provided the basis for the founding of the center. indeed, during the last seven year s the list of couples waiting thei r turn has only grown. Usually these are couples who have not yet been blessed with children. though not widely publicized, every one understands why so many couples are eagerly volunf teering for this special mitzvah. f those who cannot come in person because they live abroad often send a donation for an entire Shabbos's provisions, or parents and others do it in their name. there is a Midr ash tanchuma, Sefer Devorim, Pars has Ki teitsei, stating that the reward for hosp itality is children. the imre eme s from Gur writes, "if it is written in the Midrash, we mus t believe that it is really so." There have been many yeshout bli ayin hora. I will share two of them with you: It was our sixteenth anniversary. After going through every treatme nt known to man, we found ourselves at an imp asse. we were sitting at home eati ng our dinner, flavored with salty tears. Our doct or had effectively dismissed us there was nothing he could do for us anymore. we had exhausted all possible options. we felt defeated and resigned. Just then the phone rang. it was a close friend, who was hesitant. She wasn't sure this was the right time is it eVer the right time? ; Stam mering, she told us about this segulah: travel to Rech ovot and host a Shabbos in the mal onit run by Rav Eliyahu Yeret. Although it was neit her easy nor comfortable, we wer e at the end of our rope and ready to try anything . Since we live in eretz Yisrael we called him later that week and made arrangemen ts to host a Shabbos there. Seve ral months later he called us to invite us to once agai n host a Shabbos. with great deli ght we informed him that we had extraordinary new s to share, Boruch HaShem. i wish the same to all of Klal Yisroel! My husband and i went through twe lve years of secondary infertility. During these challenging years of our marriag e, we consulted with several doct ors and pursued varif ous treatments. we tried many segu los and traveled to different coun tries in search of the elusive yeshua. Somewhere along the line someone told us abo ut rav eliyahu Yeret's hospitality house. Since we live overseas it was very impract ical for us to implement this. Getting away for a Shabbos isn't easy, and we aren 't the types to pick ourselves up on a wild goose chas e over every suggestion. the year s went by and nothf ing was happening. One day we heard about the malonit again, but this time we were told that we didn't have to be ther e in person; just sponsoring a Shab bos was enough. we called up rav Yeret and were told that the following Shabbos was still available. we were stunned at the auspicio us timing; because we were slat ed to begin a new course of treatment the following week & we had decided to push it off for a while. to our amazement, after so many year s of heartbreak, we were blessed with a son nine months later! i hope these stories give you chiz uk and hope. if you're interested in more informaf tion about this, please contact: Hebrew & Yiddish speakers, cont act Rabbi Eliyahu Yeret at 011t972t 8t945t7544 or cell # 011t972t50t410t0101 english, French. & Flemish speakers , contact rivky at 0f2f288f8440.
This work was supported by National Institutes of Health Grant GM36415 to C. A. and was performed during the tenure of an American Heart Association Established Investigator award to C. A. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "aduertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. Present address: Dept. of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139. 11 To whom correspondence should be addressed Dept. of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111. The abbreviations used are: MBP, maltose-binding protein; CCCP, carbonyl cyanide m-chlorophenylhydrazone and metoprolol.
Weed killers, should be effective. Benefits.--Christmas vine is sometimes grown as an ornamental for the clusters of white, scented flowers it produces during the early winter. The nectar gathered from its flowers makes one of the finest honeys Woman's Club of Havana 1952 ; . Extracts from the seeds are used as an analgesic in herbal medicine Schultes and Hoffmann 1992 ; . Narcotic Properties.--The seeds of Christmas vine were valued as a sacred hallucinogen by Chinantec, Mazatec, Mixtec, Zapotec, and other groups in Southern Mexico in Pre-Columbian times and are still cultivated and used today as aids in divination and witchcraft. It was administered by grinding about 13 seeds, adding water, filtering, and drinking the filtrate in a quiet, secluded place. Hallucinations follow that last about 3 hours, sometimes with aftereffects. The active ingredients are the ergoline alkaloids, lysergic acid amide, and lysergic acid hydroxyethylamide that are closely related to LSD Schultes and Hoffmann 1992 ; . References Acevedo-Rodrguez, P. 1985. Los bejucos de Puerto Rico. Vol. 1. General Technical Report SO-58. U.S. Department of Agriculture, Forest Service, Southern Forest Experiment Station, New Orleans, LA. 331 p. Correll, D.S. and M.C. Johnston. 1970. Manuel of the vascular plants of Texas. Texas Research Foundation. Renner, TX. 1, 881 p. Howard, R.A. 1989. Flora of the Lesser Antilles, Leeward and Windward Islands. Dicotyledoneae. Part 3. Vol. 6. Arnold Arboretum, Harvard University, Jamaica Plain, MA. 658 p. Liogier, H.A. 1995. Descriptive flora of Puerto Rico and adjacent islands. Vol. 4. Editorial de la Universidad de Puerto Rico, Ro Piedras, PR. 617 p. Long, R.W. and O. Lakela. 1971. A flora of Tropical Florida. University of Miami Press, Coral Gables, FL. 962 p. Pacific Island Ecosystems at Risk. 2002. Invasive plant species: Ardisia elliptica Thunberg, Myrsinaceae. : hear pier arell . 2 p. Shultes, R.E. and A. Hoffmann. 1992. Plants of the gods. Healing Arts Press, Rochester, VT. 192 p. Woman's Club of Havana. 1952. Flowering plants from Cuban Gardens. Criterion Books, New York. 365 p. John K. Francis, Research Forester, U.S. Department of Agriculture, Forest Service, International Institute of Tropical Forestry, Jardn Botnico Sur, 1201 Calle Ceiba, San Juan PR 00926-1119, in cooperation with the University of Puerto Rico, Ro Piedras, PR 00936-4984.
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Conflict of interest statement: No conflicts declared. Abbreviations: NSAID, nonsteroidal antiinflammatory drug; COX, cyclooxygenase; TCF, T cell factor; LEF, lymphoid-enhancing factor; PPAR, peroxisome proliferator-activated receptor; RXR- , retinoid X receptor ; PBP, PPAR-binding protein; Dsh, dishevelled; RA, retinoic acid; NFAT, nuclear factor of activated T cells and monopril and lysergic.
19. LEWIS, J., C. FEENEY, R. E. GARIBALDI, J. MICHENER, H. HIRSCHMANN, D. TRAUFLER, D. LANGLYKE, A. F. LIGHTBODY, J. STUBBS, AND H. HUMFELD. 1947. Subtilin production in surface cultures. Arch. Biochem. 14: 415-425. 20. MAJUMDAR, S. K., AND S. K. BosE. 1960. Trace element requirements of Bacillus subtilis for mycobacillin formation. J. Bacteriol. 79: 564565. 21. MARY, N. Y., W. J. KELLEHER, AND A. E. SCHWARTING. 1965. Production of lysergic acid derivatives in submerged culture. III. Strain selection on defined medium. Lloydia 28: 218-229. 22. MICHELON, L. E., AND W. J. KELLEHER. 1963. The spectrophotometric determination of ergot alkaloids. A modified procedure employing p-dimethylaminobenzaldehyde. Lloydia 26: 192-201. 23. MICHENER, H. D., AND N. SNELL. 1950. Studies on cultural requirements of Claviceps purpurea and inactivation of ergotamine. Am. J. Botany 37: 52-59. 24. NASON, A., N. 0. KAPLAN, AND S. P. COLOWICK. 1951. Changes in enzymatic constitution of zinc deficient Neurospora. J. Biol. Chem. 188: 397-406. 25. NIcHOLAs, D. J. D. 1952. The use of fungi for determining trace metals in biological materials. Analyst 77: 218-229. 26. OLSON, B. H., M. J. JOHNSON. 1948. Factors producing high yeast yields in synthetic media. J. Bacteriol. 57: 235-246. 27. PAcrIcI, L. R., W. J. KELLEHER, AND A. E. SCHWARTING. 1962. Production of lysergic acid derivatives in submerged culture. I. Fermentation studies. Lloydia 25: 37-45. 28. PAcH'IcI, L. R., W. J. KELLEHER, AND A. E. SCHWARTING. 1963. Production of lysergic acid derivatives in submerged culture. II. Strain selection and screening. Lloydia 26: 161-173. 29. RuBiNs, E. J., AND G. R. HAGSTROM. 1959. Determination of aluminum and iron in plant tissue. Agr. Food Chem. 7: 722-724. 30. RUTSCHMANN, J., AND H. KOBEL. 1964. Obtaining derivatives of lysergic acid by a microbial process. Belgian Patent No. 636, 716. 31. SANDELL, E. B. 1959. Colorimetric determination of traces of metals, 3rd ed., p. 606-620. Interscience Publishers, Inc., New York. 32. SANDOZ, LTD. 1963. Lysergic acid. Belgian Patent No. 629, 158. 33. SCHWARTZ, A. K., AND D. M. BONNER. 1964. Tryptophan synthetase in Bacillus subtilis, effects of high potassium ion concentrations on a two component enzyme. Biochim. Biophys. Acta 89: 337-347. 34. SERFASS, E. J., W. S. LEVINE, P. J. PRANG, AND M. H. PERRY. 1949. Determination of impurities in electroplating solutions. XIII. Traces of zinc in nickel plating baths. Plating 36: 818-823. 35. STARKEY, R. 1955. Relations of micronutrients to development of microorganisms. Soil Sci. 79: 1-14.
| Caring for a nephrostomy tube So you are going home with a nephrostomy tube and legbag. Now what? With a bit of care, you can make this experience as comfortable as possible. You will need: tape, non-stick gauze pads, a type of combine dressing or padded dressing, and replacement leg bags. Do not use the type of gauze pad with a slit for the tube as this tends to stick to the tube and can be painful to remove. Tape the nephrostomy tube, about 4-6 inches down the tube, on a downward angle so that it ends up coming down your hip and the outside of your leg. Taping the tube in place helps relieve any pressure or pulling on the tube caused by the legbag. Place the bag on the outside of your leg at a level that you find comfortable. You do not want the tube placed on your buttocks so that you will sit on it. Sitting on the tube can cause punctures and leaks. Place the non-stick pad on the combine or padded dressing so that it faces the nephrostomy tube entry point. Tape in place taking care not to tape the bandage to the tube. I personally prefer using a 5in x 9in 12.7cm x 22.9cm ; combine dressing folded in half for additional padding, using a minimum of tape to hold the bandage in place. Tape that goes on - must come off - ouch!! Since baths are generally frowned on while wearing a tube, showers are great. A handheld shower head allows you to aim the water directly at the tube insertion point washing away any discharge. A wet or dry cloth used gently on the site will also help remove any irritating dry discharge. Take care that you do not pull on the tube or the stitch that holds it in place. Legbags come in different sizes. A smaller person would use a smaller bag. The best type is the kind that has a nozzle or flip top on the port. The types with rubber caps can easily be dislodged by pants and result in leakage. Fold the port under the bag, facing up your leg so that it is protected by the bag. This helps minimize any embarrassing accidents. Cloth Velcro or elastic legbag bands are much more comfortable than latex bands which can irritate the skin. Change your bag every week to avoid unpleasant odors. Stent Tubes This is another way in which kidney are allowed to drain. Stent tubes are often used after surgery to allow the kidney to heal and to dilate the ureters. This is useful if the ureter has narrowed due to an obstruction. They are sometimes used in conjunction with a nephrostomy. They are inserted under a general anesthetic but often removed under a local. As the bladder is a smooth muscle, Stent tubes can cause severe spasmodic pain for a period after they have been inserted. Various drugs can be used to relieve this spasm pain. Cystinurics can also find relief in using a hot water bottle on the bladder. If the stent lies on a certain place in the bladder they can also cause nerve pain. They often also cause the urethra to spasm which is very uncomfortable. The constant discomfort of a Stent tube can cause some cystinurics to become tired and run down. They can also cause and morphine.
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Vol. 3 : No.1 1982 - Article 1 of 6 useful in the prevention of anaemia. This is especially beneficial in regions of the world where health care is fairly rudimentary. Its clinical record is better than the Pill at a comparable stage of development. The demand has already been shown to exist for its long term use in many countries. Much publicity has been given to the ban on the drug in the USA. But the drug is widely used in such 'advanced' countries as Sweden and New Zealand. MISSED OPPORTUNITIES The US has one of the strictest regulatory authorities in the world, the Food and Drug Administration FDA ; . It also turns out to be the costliest in terms of missed opportunities for improved health. As the Friedmans show in Free to Choose the FDA has many pressures on it. The US is one of the most open societies in the world with a very powerful public opinion. An official can make two kinds of mistakes. He can approve a drug that turns out to have unanticipated side effects resulting in death or serious impairment of a sizeable number of individuals. Or he can refuse approval of a drug that is capable of saving or drastically improving many lives and that has no untoward side effects. If the first mistake is made - a thalidomide is approved - that agency and that individual will be villified across the nation, even across the world. The agency may be disbanded, the individual would at the very least face a more difficult future. Yet if the second mistake is made only a few well-informed doctors, chemists and patients will know and miss the drug. It is not surprising that the authority with a lot of power will refuse a lot of drugs.
The empty cells. We assumed that the FED would occur at all PCO2 above the threshold, whereas it would not appear at any PCO2 below the threshold. Empty cells having 1 at a PCO2 lower then their own and no data above their own were extrapolated to 1, and empty cells having only 1 at a PCO2 higher than their own and no data below their own were extrapolated to 1. Empty cells having 1 on both of the neighboring sides were interpolated to 1, and the same was done with 1. The ratio of CNS oxygen toxicity number of 1 signs ; to the total number of 1 and 1 signs ; in each column PCO2 interval ; and mean PCO2 were calculated. This allowed us to present the percentage of rats having the FED in the selected PCO2 intervals. FED PROBABILITY EQUATION. Because many risk functions, including the present PCO2 threshold for CNS oxygen toxicity, are sigmoidal in form, we selected the versatile Hill equation, which is used for sigmoidal responses in different fields e.g., hemoglobin oxygen saturation, dose response in pharmacology, decompression risk ; , for the FED probability equation. A sigmoid curve was fitted to the calculated percentage of FED as a function of PCO2 using nonlinear regression SAS, Cary, NC ; . We assumed that at a relatively low PO2 there should be a threshold PCO2 D ; and that when the CO2 level exceeded this threshold it would cause CNS oxygen toxicity F F0 100 F0 1 F P50 0 D PCO2 D D.
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DataStar Documents.1 Self-cognitions in antisocial alcohol dependence and recovery.1 Cluster analysis of a forensic population with antisocial personality disorder regarding PCL-R scores: differentiation of two patterns of criminal profiles.1 Adolescent homicides in Finland: offence and offender characteristics.2 Efficacy of pharmacotherapy against core traits of borderline personality disorder: meta-analysis of randomized controlled trials.2 . Drug toxicity and cost as barriers to community participation in HAT control in the Democratic Republic of Congo.3 Positive schizotypy and trauma-related intrusions.4 Quetiapine for the treatment of borderline personality disorder; an open-label study.4 Possible interaction between MAOA and DRD2 genes associated with antisocial alcoholism among Han Chinese men in Taiwan.5 Fatal erosive lichen planus.6 Chromosomal effect in vivo of exposure to lysergic acid diethylamide.6 Role of genotype in the cycle of violence in maltreated children 7 . Psychology. Violent effects of abuse tied to gene.7 Effects of increasing cognitive load on sustained attention tasks in schizophrenic disorders and schizotypy ; .7 The Michigan State University Twin Registry MSUTR ; : genetic, environmental and neurobiological influences on behavior across development.8 The Florida State Twin Registry: research aims and design.9 The Southern California Twin Register at the University of Southern California: II.9 The effect of contingent reinforcement on target variables in outpatient psychotherapy for depression: a successful and unsuccessful case using functional analytic psychotherapy 10 . Confirmatory factor analysis of the three-factor structure of the schizotypal personality questionnaire and Chapman schizotypy scales.10 Problem-solving ability and comorbid personality disorders in depressed outpatients.11 Personality differences in attempted suicide versus suicide in adults 50 years of age or older.12 The therapeutic alliance in schema-focused therapy and transference- focused psychotherapy for borderline personality disorder.12 The dynamic prediction of antisocial behavior among forensic psychiatric patients: a prospective field study.13 Sex differences in clinical predictors of suicidal acts after major depression: a prospective study.13 Attachment as moderator of treatment outcome in major depression: a randomized control trial of interpersonal psychotherapy versus cognitive behavior therapy 14 . Longitudinal effects of personality disorders on psychosocial functioning of patients with major depressive disorder.15 Psychopathology, personality traits and social development of young first-degree relatives of patients with schizophrenia.16 Relationship between personality disorder symptoms and temperament in the young male general population of South Korea.16 Interhemispheric integration in psychopathic offenders.17 Aggressiveness, not impulsiveness or hostility, distinguishes suicide attempters with major depression.18 Intramuscular olanzapine in patients with borderline personality disorder: an observational study in an emergency room.18 . Long-term changes in self-reported personality following capsulotomy in anxiety patients.19 Perceptual grouping in disorganized schizophrenia.20 Abnormal typicality of responses on a category fluency task in schizotypy.20 Deficits in visual functions and neuropsychological inconsistency in Borderline Personality Disorder.21 The relationship between perfectionism, eating disorders and athletes: a review.21 Aggression and substance abuse in bipolar disorder 22 . From theory to practice: the application of attachment theory to assessment and treatment in forensic mental health services 23 . Sleep architecture in homicidal women with antisocial personality disorder--a preliminary study 23 . Individual differences in emotional processing and reactivity to pain among older women with.
Counseling means meeting and talking with a therapist, alone or in a group, on a regular basis. Therapists are medically trained professionals psychologists or psychiatrists ; who know how to help depressed patients. You can talk to your family doctor about the type of therapy you need and how to pick a therapist. They should be able to give you a referral to a good therapist. Other people who can give you reliable referrals are the psychiatry department of a well-respected hospital or medical school, and local AIDS service organizations.
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Propofol and midazolam have pharmacokinetic advantages over the barbiturates, which readily accumulate in fat and muscle, leading to prolonged action after stopping the infusion.
Hospital pharmacy volume 39, number 10, pp 976987 2004 wolters kluwer health, inc.
These characteristics have led to the emergence of a new paradigm in computing: the agent paradigm. An increasing number of computer systems are being viewed in terms of multiple, interacting autonomous agents. This is because the multi-agent paradigm offers a powerful set of metaphors, concepts and techniques for conceptualising, designing, implementing and verifying complex distributed systems [Jennings, 2001]. An agent is viewed as an encapsulated computer system that is situated in an environment and is capable of flexible, autonomous action in order to meet its design objectives [Wooldridge, 2002]. Applications of agent technology have ranged from electronic trading and distributed business process management, to air-traffic and industrial control, to health care and patient monitoring, to gaming and interactive entertainment [Jennings and Wooldridge, 1998, Parunak, 1999]. In multi-agent systems, agents need to interact in order to fulfil their objectives or improve their performance. Generally speaking, different types of interaction mechanisms suit different types of environments and applications. Agents might need mechanisms that facilitate information exchange, coordination in which agents arrange their individual activities in a coherent manner ; , collaboration in which agents work together to achieve a common objective ; , and so on. One such type of interaction that is gaining increasing prominence in the agent community is negotiation. We offer the following definition of negotiation, adapted from work on the philosophy of argumentation [Walton and Krabbe, 1995]: Negotiation is a form of interaction in which a group of agents, with conflicting interests and a desire to cooperate, try to come to a mutually acceptable agreement on the division of scarce resources. The use of the word "resources" here is to be taken in the broadest possible sense. Thus, resources can be commodities, services, time, money etc. In short, anything that is needed to achieve something. Resources are "scarce" in the sense that competing claims over them cannot be fully simultaneously satisfied. In a multi-agent system context, the challenge of automated negotiation is to design mechanisms for allocating resources among.
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