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The benefit of maintenance paclitaxel, in terms of improvement of remission duration before relapse survival benefit has not been shown ; , had been demonstrated in the treatment of advanced ovarian cancer3. The Italian MANTA study is the equivalent in ABC. The final results were reported during the meeting Gennari et al #522 ; . Patients with MBC achieving a response or stable disease to first-line chemotherapy including anthracyclines and paclitaxel, were randomised to maintenance paclitaxel or observation only. The initial Exit Print hypothesis was Home that maintenance paclitaxel could.
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Objectif : La mthadone, opiac habituellement associ au traitement des dpendances aux opiacs, est prescrite de plus en plus comme analgsique pour diverses douleurs chroniques. Malgr sa popularit croissante, la plupart des anesthsiologistes n'en connaissent pas la pharmacologie complexe. Nous avons revu la pharmacologie et recommander un algorithme de traitement priopratoire pour les patients traits avec la mthadone. Source : Une recherche dans Medline a t ralise pour obtenir les publications sur la pharmacologie de la mthadone et son usage priopratoire. Constatations principales : La complexit de la pharmacologie de la mthadone est caractrise par une grande variabilit inter-individuelle, un potentiel d'interaction avec d'autres mdicaments et une longue demi-vie d'limination. Le traitement postopratoire des patients sous mthadone peut tre difficile, car ils prsentent souvent une tolrance aux opiacs, mais ils peuvent tre intolrants la douleur. Dans les cas de traitements d'entretien la mthadone, il y a des problmes possibles avec l'usage d'opiacs ou d'autres substances. Le plan de traitement des patients sous mthadone peut diffrer selon le type de chirurgie et les diffrences priopratoires associes de l'tat de jene et de la fonction gastro-intestinale. En considrant tous ces facteurs, un algorithme de traitement est trac pour les soins priopratoires des patients sous mthadone. Conclusion : La mthadone est un opiac aux proprits complexes et l'anesthsie d'un patient sous mthadone peut reprsenter un grand dfi. Une bonne connaissance de sa pharmacologie et du type de patients qui en consomment aidera amliorer les soins priopratoires.
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1 Barker DJ, Hales CN, Fall CH, Phipps K, Clark PM. Type 2 non-insulindependent ; diabetes mellitus, hypertension and hyperlipidaemia syndrome X ; : relation to reduced foetal growth. Diabetologia 1993; 36: 62-7. Valdez R, Athens MA, Thompson GH, Bradshw BS, Stern MP. Birth-weight and adult health outcomes in a biethnic population in the USA. Diabetologia 1994; 37: 624-31. Orahilly S, Spivey RS, Holman RR, Nugent Z, Clark A, Turner RC. Type-II diabetes of early onset--a distinct clinical and genetic syndrome BMJ 1987; 294: 923-8. Ekinsmyth C, Bynner JM, Montgomery SM, Shepherd P. An Integrated approach to the design and analysis of the 1970 British Cohort Study BCS70 ; and the National Child Development Study NCDS ; . London: Centre for Longitudinal Studies, University of London, 1992. Ferri E. Life at 33: the fifth follow-up of the National Child Development Study. London: National Children's Bureau, 1993.
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Patient. A lung function test should be performed in the initial stage. Bronchoscopy with broncho-alveolar lavage 9 ; and or transbronchial biopsy is essential. Thank you verv much. ACKNOWLEDGEMENT This presentation had been partly supported by the Medical Faculty Grant for Medical Publication and the Development of Medical Teaching Grant No. 365 030 4213 ; . The editor would like to thank Miss F. Ng for her excellent secretarial assistance.
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41% at age 45 to 54 years, 21% 38% at 55 to 64 years, 18% 30% at 65 to 74 years, 13% 19% at 75 to 84 years, and 9% 13% at 85 to 89 years. In every age group, nitrate angina in women was associated with increased coronary SMRs similar in magnitude to those observed in men FIGURE 2 ; . In contrast, women with test-positive angina aged 45 to 74 years had higher coronary SMRs than men Figure 2 ; . For example, among those aged 55 to 64 years, the SMR was 4.69 95% CI, 3.60-6.11 ; in women and 2.40 95% CI, 2.11-2.73 ; in men P .001 for interaction ; . Within strata defined by age and sex, associations with coronary mortality were stronger for test-positive angina than for nitrate angina. As shown in TABLE 1, women with angina were older than men and, in ageadjusted analyses, were slightly more likely to be using short-acting nitrates.
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Infarction MI ; . Gynecomastia and hyperkalemia are common adverse effects. -blockers Several mechanisms have been presented to explain the hypotensive effect of -blockers. Beta blockers reduce cardiac output through negative inotropic and chronotropic effects on the heart, decrease cardiac contractility, lower heart rate, reduce central release of adrenergic substances, inhibit peripheral epinephrine release, decrease renin release, diminish sympathetic reflex in response to exercise, and lower arterial pressure.19, 23, 24 According to JNC 7, -blockers are indicated for high-risk conditions such as heart failure, postmyocardial infarction, and diabetes, and for patients at increased risk for cardiovascular disease.2, 24 There are 3 types of -blockers: nonselective, cardioselective, and intrinsic sympathomimetic activity ISA ; . Each demonstrate different properties Table 7 ; . Beta-1 receptors are primarily found in the heart, while beta-2 receptors are found in the kidneys, lungs, and peripheral arteriolar endothelium.24 Nonselective -blockers respond to inhibitory activity at both beta-1 and beta-2 receptors. Cardioselective -blockers demonstrate beta-1 blocking activity at low doses. At higher doses, selectivity for beta-1 adrenergic receptors is diminished. Cardioselective -blockers are beneficial in patients with 6.
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A. Sygros Hospital, 5 Ionos Dragoumi Str., Athens 16121, Greece] - J. COSMET. DERMATOL. 2006 5 3 ; - summ in ENGL Superficial chemical peeling SCP ; involves the application of a peeling agent to the skin, resulting in destruction of part or all of the epidermis. SCP is mainly recommended for facial rejuvenation, photoaging and superficial rhytides, pigmentary dyschromias and acne. It can be used on all Fitzpatrick skin types, no sedation is needed, and the desquamation is usually well accepted. Overpeel and complications are very rare. The most commonly used SCP agents are glycolic acid 20-70%, trichloroacetic acid 10-35%, Jessner's solution, salicylic acid, pyruvic acid, resorcinol 30-50% preparations, and solid carbon dioxide. The careful selection of patients is critical for the outcome of a SCP and contraindications must be seriously considered. The peel procedure is generally common for all SCP agents but a good knowledge of the specific characters of each agent is of great importance in order to decide which to use for each individual patient. 2006 Blackwell Publishing. 905. Use of intense pulsed light and a retinyl-based cream as a potential treatment for cellulite: A pilot study - Fink J.S., Mermelstein H., Thomas A. and Trow R. [Dr. J.S. Fink, PO Box 144, South Salem, NY 10590, United States] - J. COSMET. DERMATOL. 2006 5 3 ; - summ in ENGL Background: There are few therapeutic treatments established for cellulite. Objective: We studied the response of intense pulsed light IPL ; treatment with or without a compounded prescription retinylbased cream on a small group of patients who had visible cellulite present on the buttocks and thigh regions. Patients and methods: Twenty patients were selected to complete a 12-week course of IPL treatment either with or without a retinyl-based cream. Assessment was based on visual evaluation, photographs, skin ultrasounds, and patient satisfaction. Results: Fifteen 75% ; completed the study, and nine 60% ; had a self-improvement rating of 50%. Seven 78% ; of nine patients used IPL cream. Of the remaining six 40% ; completing the study, four 27% ; had self-improvement ratings of 25-50% and two 13%; IPL only ; were considered treatment failures with a rating of 10-25%. Both IPL cream and IPL-only groups exhibited an improvement in the smoothness of the affected area even following weight gain. Skin ultrasounds confirmed an increase in the deposition of collagen. During an 8-month phone follow-up, 8 67% ; of 12 responding reported the same or improved results. Conclusion: IPL treatment with or without a retinyl-based cream can improve the appearance of peau d'orange cellulite, though the cream may augment cosmetic improvement. This approach is well tolerated, has minimal side effects, and is accompanied by a high degree of patient satisfaction. 2006 Blackwell Publishing. 906. Novel cutaneous uses for botulinum toxin type A - Bansal C., Omlin K.J., Hayes C.M. and Rohrer T.E. [C. Bansal, Drexel University College of Medicine, 2967 Schoolhouse Lane, C-602A, Philadelphia, PA 19144, United States] - J. COSMET. DERMATOL. 2006 5 3 ; - summ in ENGL Botulinum toxin type A is a neurotoxin produced by the bacterium Clostridium botulinum which causes a flaccid muscle paralysis. It has been used extensively in the field of dermatology for the treatment of dynamic rhytides and in the treatment of hyperhidrosis. Botulinum toxin has an excellent safety profile and few side effects when used for these purposes. Recently, botulinum toxin has also been used experimentally in a number of other dermatologic conditions with good results. These conditions include: persistent facial flushing, gustatory sweating and epiphora, anal fissures, familial benign pemphigus Hailey-Hailey disease ; , dyshidrotic eczema, and following surgical wound closures. While randomized, controlled prospective trials are still needed to further understand the efficacy and safety of botulinum toxin in these conditions, anecdotal and case report data suggest that botulinum toxin is both safe and efficacious in these and many other procedures. 2006 Blackwell Publishing. 907. A case of juvenile subcorneal pustular dermatosis successfully treated with acitretin [17] - Yayli S., Bahadir S., Alpay K. et al. [Dr. S. Yayli, Karadeniz Technical University, Trabzon, Turkey] - INT. J. DERMATOL. 2006 45 9 ; 908. Pimecrolimus is effective in Fox-Fordyce disease [18] c a Pock L., Svr kov M., Mach ckov R. and Hercogov J. [Dr. L. a a 132 and micardis.
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In contrast to the low density of GABA-ir cells, the central nucleus had one of the highest densities of GABA-ir fiber and terminal labeling Fig. 8, Table 1 ; . There were no clear differences in the density of neuropil labeling in the medial and lateral divisions of the central nucleus. Fiber and terminal labeling had a diffuse appearance, and there were few basket-like plexuses. We did, however, observe long, often transversely oriented thick profiles that were made up of parallel strings of immunoreactive varicosities Fig. 5C ; . These were particularly prominent in the lateral division of the nucleus and were possibly segments of dendrites studded with GABAergic varicosities. They resembled the so-called "woolly fibers" Haber and Elde, 1982; Haber and Nauta, 1983; Amaral et al., 1989 ; that have been reported in the amygdala and substantia innominata in peptide immunohistochemical preparations. Amygdalohippocampal area. The amygdalohippocampal area contained a very high number of GABA-ir neurons 198 cells mm2 ; that were similar to those in the periamygdaloid cortex Fig. 209. Many in situ labeled cells were evenly distributed in the amygdalohippocampal area GAD mRNA, 158 cells mm * ; GAD mRNA, 13 1 cells mm * ; Figs. 6, 7, 11C ; . GABA-ir neuropil staining was also high in the amygdalohippocampal area Table 1 ; and basket-like plexuses around unstained cell bodies were common. Intercalated nuclei. In most of the intercalated nuclei Fig. 2A'-C' ; the number of GABA-ir cells was substantially higher than observed in the deep nuclei. In fact, in some intercalated nuclei, essentially all of the small neurons appeared to be labeled Fig. 10A ; . However, due to the light staining of individual neurons and the relatively dense neuropil staining in which they were embedded, it was often difficult to visualize stained cell profiles. A few apparent intercalated nuclei demonstrated substantially fewer labeled cells [Fig. 2, B' latera1 to anterior cortical nucleus ; and D' dorsal to the lateral nucleus ; ]. A very high number of cells containing GAD mRNAs was also found in the t.
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Table of Contents 1. Introduction 2. Stress in French 3. Earlier evidence for the foot in child QF 4. Overview of data source and stages in development 5. Word minimality in Clara's grammar 6. The lexical functional split 7. Conclusion References.
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