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Introduction: Persistent Hyperplastic Primary Vitreous PHPV ; can have wide clinical presentations. Most cases tend to be unilateral though review of various cases from the literature shows it to be present in both eyes of 11% of cases. 1. The cases that present bilaterally have associated systemic anomaly and die at a younger age. Our patient has no systemic abnormality; a similar case of bilateral PHPV without any systemic disease has been reported earlier. 2. Buphthalmos due to secondary glaucoma is an important late presentation of PHPV and has been reported in 26% of the cases. 3. One eye of our patient had buphthalmos with IOP of 19.4mmHg. Glaucoma in PHPV could result from recurrent vitreous hemorrhage, which is the most likely mechanism in our case 3. Aim of the study : To present as poster a rare case of bilateral PHPV with buphthalmos in one eye. Method: A five-month-old male infant was seen in out patient with history of bilateral leucocoria since the age of four months. Results: Examination of eyes under general anesthesia showed: Right eye corneal diameter of 14mm in horizontal and 13.5mm in vertical meridian. Anterior chamber was shallow. Iris showed blood vessels going from iris to the lens surface with ectropion uvea. The lens was clear. There was no view of the fundus other than a red glow from dense vitreous hemorrhage. Intraocular pressure was 19.4mmHg with Schioz tonometer. Left eye: Corneal diameter was 9.5 mm in horizontal and vertical meridian. Anterior chamber was normal. Lens was clear. There was a fibrovascular membrane on the posterior surface of the lens obscuring the fundus view. Intraocular pressure was 14.6mmHg. B scan ultrasonography of the right eye was suggestive of vitreous hemorrhage with a fibrous band from disc to posterior lens surface. Left eye scan showed a similar hyper echoic shadow from disc to posterior lens surface suggestive of fibrous band from disc to posterior lens surface. MRI scan on T1 image showed hyper intense echoes from vitreous cavity of right eye and central hypo intense echoes from disc area to the posterior lens surface in both eyes . Histopathology of the right eye showed dense fibro vascular band extending from disc to posterior surface of lens confirming diagnosis of PHPV. The left eye underwent pars plana lensectomy with vitrectomy. After lensectomy ciliary processes were seen to be dragged towards the center and retina was thrown into fixed folds and was incarcerated into the fibro vascular band. Conclusion: Bilateral PHPV is a rare disorder and sometimes can present as secondary glaucoma due to recurrent vitreous haemorrhage. References : 1. Haddad R, Font R, Reeser F. Persistent hyperplastic primary vitreous: a clinicopathological study of 62 cases and review of literature. Surv ophthal 1978; 23: 123-134. Magnus H. Doppelseitiges Pseudogliom, yorgetauscht durch Bindegewebsbildung hinter der Linse mit Arteria hyaloidea persistens bei Mikroophthalmos. Graefes Arch Exp Ophthamol 1927; 59: 271-286. Alward WLM, Krasnow MA, Keech RV, Pulido JS et al Persistent hyperplastic primary vitreous with glaucoma presenting in infancy. Arch Ophthalmol 1991; 109: 1063-1064.
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ACADEMIC TRAINING 1967-1971 St. Joseph's University, Philadelphia, Pennsylvania. B.S. in Chemistry. 1971-1975 Texas A&M University - College Station, Texas. Received Ph.D. in Bio-Organic Chemistry see below for minor ; . 1972-1974 Baylor College of Medicine - Houston, Texas. Department of Microbiology. Graduate Minor in Medical Microbiology and Biochemistry. EXPERIENCE TEACHING 9 71 - 6 Texas A&M University - Graduate Teaching Assistant, Dept. Chemistry. 10 77 - 6 The Ohio State University - Assistant Professor, Depts. Radiology and Pharmacology. 7 82 - 6 The Ohio State University - Associate Professor, Depts. Radiology and Pharmacology. 7 85 - present The Ohio State University - Professor, Depts. Radiology and Pharmacology. RESEARCH 6 72 - 6 present and phentermine.
James Salzer MD, PhD New York University Medical Center New York, NY NMSS Area: New York City Chapter Award: Research Grant Term Amount: 4 1 06-3 7, 079 2005 Stephen C. Reingold Research Award "Regulation of CNS myelination and remyelination by neuregulin1" Determining the role of a molecule in myelin formation and repair, for clues to developing repair strategies in people with MS. In multiple sclerosis, the myelin sheaths that insulate nerve fibers are broken down by immune cells, resulting in damage and loss of nerve fibers also known as axons ; , abnormalities of nerve impulse conduction and significant neurologic disability. For reasons that are not well understood, once myelin is damaged, it is poorly repaired. Researchers have demonstrated that the survival of the myelin sheath is actually regulated by signals from the axon. James L. Salzer, MD, PhD, is studying the mechanisms by which axons regulate myelin formation in order to learn more about molecules that may be affected by MS, and to develop strategies for repairing myelin in this disease. Dr. Salzer's team has determined that a "growth factor" found on the surface of axons neuregulin1 strongly promotes myelin formation. Now they are studying whether neuregulin1 is required to initiate myelin formation and maintenance, by examining mice in which neuregulin can be deleted at various stages. The team is also inducing myelin damage in these mice and tracking subsequent repair processes to determine whether neuregulin plays a role in myelin repair.
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Compounds targeting the neuroendocrine feedback mechanisms in the central nervous system, such as NPY Y5 antagonists and melanorcortin-4 receptor agonists, CART cocaine- and amphetamine-regulated transcript ; and serotinin 5HT2C agonists. An example of the latter, sibutramine, is already in clinical practice. Drugs that influence thermogenesis, such as 3 adrenoreceptor agonists and uncoupling agents. The first 3 adrenoreceptor agonist was developed in the 1980s and showed efficacy in weight reduction, but its low selectivity led to serious adverse events and eventually to its withdrawal. The most effective uncoupling agents are thyroxine and thyroid hormones, but again these are not sufficiently specific for fat tissue. Furthermore, they induce tolerance, which implies that very high pharmacological dosages would be needed. Inhibitors of fat digestion in the gut, e.g. orlistat. Leptin-like substances, such as recombinant human leptin and low molecular weight leptin agonists. Sibutramine To the first class belong compounds that alter appetite neurotransmission. They either act by inhibiting feeding or by enhancing neurotransmitter suppression. The serotonin 5HT2C agonist sibutramine marketed as Reductil in Europe and as Meridia in the USA ; was originally developed as an antidepressant. It has both serotonergic and noradrenergic actions, enhancing the effect of the neurotransmitters on the target neurons and suppressing the desire to eat. The expectation that the noradrenergic effect would enhance peripheral thermogenesis has not been substantiated in clinical practice. The two-year Sibutramine Trial of Obesity Reduction and Maintenance STORM; James et al., 2000 ; studied the effect of sibutramine on weight maintenance after weight loss. During the first six months of the trial all patients n 605; BMI 30-45 ; received sibutramine, resulting in an impressive.
Eric M. Friedlander joint with Vincent Franjou ; Cohomology of Bifunctors . 2405 Nadia Mazza joint with Jon F. Carlson and Daniel K. Nakano ; Endotrivial modules for finite groups of Lie type . 2407 Alexander Zimmermann Invariance of generalized Reynolds ideals under derived equivalence . 2410 Luchezar L. Avramov joint with Oana Veliche ; Stable cohomology algebra of local rings . 2412 Michael A. Jackson Homotopy rank and small rank groups . 2415 Jean Lannes joint with Jean Barge ; Sturm sequences and H2 of the hyperbolic homomorphism . 2418 Peter Symonds Cyclic group actions on polynomial rings . 2421 Bernhard Hanke joint with Volker Puppe ; Equivariant Gysin maps and pulling back fixed points . 2423 Henning Krause joint with Aslak B. Buan, yvind Solberg ; A universal construction of support varieties . 2424 Frederick R. Cohen joint with Alejandro Adem ; On spaces of homomorphisms . 2426.
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Mr. L was no stranger to hospitals. He had health problems stretching back at least a decade. He had had a liver transplant, a triple bypass and prostate surgery, and he had diabetes. He may have been sickly and not young at 74 but his family did not expect him to die. His visit to the hospital was to get his nails clipped, a medical procedure for diabetics. The story of Mr. L and his family, as told to the Commission, reflects the confusion in the early days of the outbreak and ends with their complaints about the lack of information and stigmatization within their community. After the procedure, Mr. L returned home and developed a high temperature. The family doctor suspected a urine infection. His family drove him to a hospital, where they noticed there were more people in emergency than usual. Mr. L was admitted and when his family visited him the next day, things were not going well. He had trouble breathing and a nurse said he had had a very bad night. His breathing got worse and around 11 a.m. the family was told he would be taken to the intensive care unit. At 4: 30 p.m. they were told Mr. L must go to another hospital because there was.
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