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Activating subscriptions document delivery linking to ingentaconnect alerting & rss feeds other library services keeping in touch register improvement of the chromatographic separation of several 1, 4-dihydropyridines calcium channel antagonist drugs by experimental design authors: baranda, ana 1 ; etxebarria, nestor 1 ; jimé nez, rosa 1 ; alonso, rosa 1 source: journal of chromatographic science , volume 43, number 10, november-december 2005 , pp. Objective: To discuss harm reduction in the context of sex work and to propose a health promotion model for sex work harm reduction. Methods: Review of the literature and application of health promotion modeling techniques Results: The concept of `harm reduction' can be easily adapted to sex work. The harms associated with sex work include drug abuse, disease, violence, discrimination, debt, criminalization and exploitation. General strategies that can be implemented to reduce the harm associated with sex work include education, prevention, diagnosis and treatment, improved conditions, decriminalization of the victims, career alternatives and support. There are specific and feasible tactics that can be implemented to reduce some of the harms of sex work such as peer education, adequate vaginal lubrication, routine vaccinations, no kissing, being on top and facing customers during sex, working in pairs, NOT using seat belts and learning simple self-defense tactics. The Sex Work Journey Model proposed includes four stages: determinants of health, sex work harms, diminished quality of life and sex work harm reduction strategies. The Journey Model introduces factors that influence movement between the stages - despair, time, event and desire. Conclusions: The concept of sex work harm reduction is reasonable and informative. Viewing sex work within the framework of harm reduction makes it easier to understand specific issues in the lives of individual sex workers. The Sex Work Journey Model can assist health promotion and education planning. 1. American Dietetic Association, Dietitians of Canada: Manual of Clinical Dietetics, 6th ed. ADA and DC, October 2000 Chapter 1: Nutrition Assessment of Adults ; 2. McCullough AJ, Teran JC, Bugianesi E: Guidelines for nutritional therapy in liver disease. In Klein ES ed ; : ASPEN Nutritional Support Practice Manual. Silver Springs, MD: American Society for Parenteral and Enteral Nutrition, 1998: 12.112.11 3. Teran FC, McCullough AF: Nutrition in liver diseases. In Gottschlich MM ed ; : The Science and Practice of Nutrition Support: A Case-Based Core Curriculum. American Society for Parenteral and Enteral Nutrition. Dubuque, Iowa: Kendall Hunt Publishing Company, 2001: 537552 4. Plauth M, Merli M, Kondrup J et al: ESPEN guidelines for nutrition in liver disease and transplantation. [Consensus Statement] Clin Nutr 1997; 16: 4355 Bashir S, Lipman TO: Nutrition in gastroenterology and hepatology. Prim Care 2001; 28 3 ; : 629645, vii 6. Lacey SW, Richter JE, Wilcox CM: Acute and chronic hepatitis, fulminant hepatic failure. In Andreoli TE, Bennett CJ, Carpenter CC et al eds ; : Cecil Essentials of Medicine, Philadelphia, PA: WB Saunders Co, 1993: chaps 41, 42 7. Selberg O, Burchert W, Hoff JV et al: Insulin resistance in liver cirrhosis: positron-emission tomography scan analysis of skeletal muscle glucose metabolism. Clin Investig 1993; 91: 18971902 Munro HN, Fernston JD, Wurtman RJ: Insulin, plasma amino acid imbalance, and hepatic coma. Lancet 1975; 1: 722724 Matos C, Porayko MK, Francisco-Ziller N et al: Nutrition and chronic liver disease. [Review] J Clin Gastroenterol 2002; 35 5 ; : 391397 10. Scolapio JS, Bowen J, Stoner G et al: Substrate oxidation in patients with cirrhosis: comparison with other nutritional markers. J Parenter Enteral Nutr 2000; 24 3 ; : 150153 11. Shronts E, Fish J: Hepatic failure. In Nutrition Support Dietetics: Core Curriculum. Silver Springs, MD: American Society for Parenteral and Enteral Nutrition Publishing, 1993: 311325 12. Detsky AS, McLaughlin JR, Baker JP et al: What is subjective global assessment of nutritional status? J Parenter Enteral Nutr 1987; 11 1 ; : 813 13. McCullough AJ, Mullen KD, Kalhan SC: Measurement of total body and extracellular water in cirrhotic patients with and without ascites. Hepatology 1991; 14: 11021111 Naveau S, Belda E, Borotto E et al: Comparison of clinical judgment and anthropometric parameters for evaluating nutritional status in patients with alcoholic liver disease. J Hepatol 1995; 23: 234235 Loguercio C, Sava E, Marmo R et al: Malnutrition in cirrhotic patients: anthropometric measurements as a method of assessing nutritional status. Br J Clin Pract 1990; 44 3 ; : 98101 16. Caregaro L, Alberino F, Amodio P et al: Malnutrition in alcoholic and virus-related cirrhosis. J Clin Nutr 1996; 63 4 ; : 602 609 17. Health and Welfare Canada: Nutrition Recommendations: The Report of the Scientific Review Committee. Ottawa: Minister of Supply and Services Canada, 1990 18. Richardson RA, Davidson HI, Hinds A: Influence of the metabolic sequelae of liver cirrhosis on nutritional intake. J Clin Nutr 1999; 69 2 ; : 331337 19. Wong K, Visocan BJ, Fish J: Nutrition management of the adult with liver disease. In Skipper A ed ; : Dietitian's Handbook of Enteral and Parenteral Nutrition. Rockville, MD: ASPEN Publishers Inc., 1998 20. American Dietetic Association, Dietitians of Canada: Manual of Clinical Dietetics, 6th ed. ADA and DC, October 2000 Chapter 29: Liver Disease ; 21. Hasse J, Weseman B, Fuhrman MP et al: Nutrition therapy for end-stage liver disease: a practical approach. Support Line 1997; 19: 815 Nompleggi DJ, Bonkovsky HL: Nutritional supplementation in chronic liver disease: an analytical review. Hepatology 1994; 19: 518533 Plevak DJ, Di Cecco SR, Wiesner RH et al: Nutritional support for liver transplantation: identifying caloric and protein requirements. Mayo Clin Proc 1994; 69: 225230 Corish C: Nutrition and liver disease. Topics Clin Nutr 1997; 55: 1720 American Dietetic Association, Dietitians of Canada: Manual of Clinical Dietetics, 6th ed. ADA and DC, October 2000 Chapter 41: Liver Transplant ; 26. Fields-Gardner C, Ayoob KT: Nutrition intervention in the care of persons with human immunodeficiency virus infection. Position of the American Dietetic Association and Dietitians of Canada. J Diet Assoc 2000; 100 6 ; : 708717.

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J. Biochem. 173, 45-51 calcium concentrations were increased t o 1.2 or 2.4 mM 24 ; . shown in Fig. 5, CRABP-I1mRNA levels respond t o 10. Stoner, C.M., and Gudas, L. J. 1989 ; CancerRes. 49, 14971504 confluence and external calcium in an identical fashion. These 11. Giguere, V., Lyn, S., Yip, P., Siu, C.-H., and Amin, S. 1990 ; results strongly favor the concept that the stratified structure Proc. Natl. Acad. Sci. U. S. A. 87, 6233-6237 of the epidermis and or the presence dermis is an important12. Petkovich, M., Brand, N. J., Krust, A and Chamhon, P. 1987 ; of Nature 330, 444-450 determinant of CRABP-I1 regulation in uiuo and may help to account for the differential responsiveness keratinocytes to 13. Brand, N., Petkovich, M., Krust, A Chamhon, P., de The, H., of Marchio, A., Tiollais, P., and Dejean, A. 1988 ; Nature 332, RA in uitro and in uiuo. The negative effect of high concen850-853 trations of RAon CRABP-I1 expression seen in uitro is similar 14. Benbrook, D., Lernhardt, E., and Pfahl, M. 1988 ; Nature 333, to the effect of this compound on transglutaminase type I 669-672 mRNA levels in cultured keratinocytes 36 ; . 15. Zelent, A., Krust, A., Petkovich, M., Kastner, P., and Chamhon, P. 1989 ; Nature 339, 714-717 Whether RA induction of the human CRABP-I1 gene occurs at thelevel of transcription and whether this regulation 16. Krust, A., Kastner, P., Petkovich, M., Zelent, A., and Chambon, P. 1989 ; Proc. Natl. Acad. U. S. is mediated by specific nuclear receptors remains to be inves- 17. Mangelsdorf, D. J. Ona. E. Sci. Dvck. A. 86, 5310-5314 R. M. S. " , and Evans tigated. It has been shown that human skin as as cultured well 1990 ; Nature 345, 254-229 human skin fibroblasts express RAR-7 16, 37 ; . However, this 18. Takase. S. Onp, D.E. and Chvtil. F. 1986 ; Arch.Biochem . Biophys. 247r328-334 doesnotexplainthe lack of RA induction of CRABP-I1 mRNA seen in cultured human lung fibroblasts and keratin- 19. Maden, M., Ong, D. E., Summerbell, D., and Chytil, F. 1988 ; Nature 335, 733-735 ocytes, also known to express RAR-7 37 ; . If the CRABP-I1 20. Siegenthaler, G., Saurat, J.-H., Hotz, R., Camenzind, M., and gene is regulated by the RARs, additional factors tissue or Merot, Y. 1986 ; J. Inuest. Dermatol. 86, 42-45 cell specific ; may be required for RA induction. 21. Hirschel-Scholz, S., Siegenthaler, G., and Saurat, J.-H. 1989 ; Eur. J. Clin. Inuest. 19, 220-227 Insummary, we have demonstratedthatCRABP-I1is in gene expressed in human skin vivo and that this is regulated 22. Siegenthaler, G., and Saurat, J.-H. 1987 ; Arch. Dermatol. 123, 1690-1692 in uitro. 23. Siegenthaler, G., Saurat, J.-H., and Ponec, M. 1988 ; Ezp. Cell by RA in skinandinculturedskinfibroblasts However, CRABP-I1 was not induced by RA in cultured lung Res. 178, 114-126 fibroblasts, demonstrating cell-specific regulation of this gene. 24. Pillai, S., Bikle, D. D., Mancianti, M.-L., Cline, P., and Hincenbergs, M. 1990 ; J. Cell. Physiol. 143, 294-302 CRABP-I on the other hand, is not regulated by RA and is found a t very low or undetectable levels in human skin in 25. Elder, J . T., Tavakkol, A., Klein, S. B., Zeigler, M. E., Wicha, M., and Voorhees, J. J. 1990 ; J. Inuest. Dermatol. 94, 19-25 uiuo as well as in keratinocytes and fibroblasts. This suggests 26. Maniatis, T., Fritsch, E. F., and Sambrook, J. 1982 ; Molecular thatCRABP-I1 may participatein a regulatoryfeedback Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, mechanism to control the action RA on cell differentiation of Cold Spring Harbor, NY in skin. The identification of human CRABPs, RARs, and 27. Sanger, F., Nicklen, S., and Coulson, A. R. 1977 ; Proc. Natl. Acad. Sci. U. S. A. 74, 5463-5467 RXRs now allows studies on interactions between members of these families in thecomplex molecular and cellular mech- 28. Boyce, S. T., and Ham, R. G. 1986 ; in I n Vitro Modelsfor Cancer Research Weber, M.M., and Sekely, L. I., eds ; Vol. 3, pp. 245anisms of RA action. 274, CRC Press, Boca Raton, FL and flunarizine. Tricor a bibliography, medical dictionary, and annotated research guide to internet references tricor ; p a p march 2001, the national institutes of health issued the following warning: the number of web sites offering health-related resources grows every day.
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