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Table 4: Treatment-Emergent Adverse Event Incidence in the Dose-Response Trial * ZYBAN 100 to 300 mg day Body System Adverse Experience Body General ; Neck pain Allergic reaction Cardiovascular Hot flashes Hypertension Digestive Dry mouth Increased appetite Anorexia Musculoskeletal Arthralgia Myalgia Nervous system Insomnia Dizziness Tremor Somnolence Thinking abnormality Respiratory Bronchitis Skin Pruritus Rash Dry skin Urticaria Special senses Taste perversion than in the placebo group. 2 1 * Selected adverse events with an incidence of at least 1% of patients treated with ZYBAN and more frequent 3 2 461 ; % Placebo n 150.
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Date: 04 03 01ISR Number: 3694465-0Report Type: Expedited 15-DaCompany Report #B0102365A Age: 56 YR Gender: Female I FU: I Outcome Dose Duration Life-Threatening 150MG Twice Hospitalization per day 18 DAY Initial or Prolonged RESPIRATORY INHALATION ; Respiratory Acidosis 5MG Per day Oestrone .625MG Per day C ORAL Medroxyprogesterone C ORAL PT Circulatory Collapse Convulsion Loss Of Consciousness Metabolic Acidosis Salbutamol C Glaxo Wellcome Report Source Product Zyban Role PS Manufacturer Glaxo Wellcome Route ORAL.
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As discussed in item g ; above, in the past, the Group established a Novartis employee share participation foundation to assist the Group in meeting its obligations under various employee benefit plans and programs. This foundation supports existing, previously approved employee benefit plans. For US GAAP purposes, the Group consolidates the Novartis employee share participation foundation. The cost of Novartis AG shares held by the foundation is shown as a reduction of shareholders' equity in the Group's balance sheet. Any dividend transactions between the Group and the foundation are eliminated, and the difference between the fair value of the shares on the date of contribution to the foundation and the fair values of the shares at December 31, is included in consolidated retained earnings. Shares held in the foundation are not considered outstanding in the computation of US GAAP earnings per share and adalat. Table B.1 continued Fate of Process agent Activity ODS used Details of use of process agent Solvent for chlorination of phenol to 2, 6No data dichlorophenol Solvent for hydrochlorination of D - ; Separation by filtration, solvent alpha phenyl glycine and recycled to reaction stage. for product purification. Solvent for direct chlorination of polypropylene but no process details Tail gas treatment by active carbon adsorption Internal Recycle Emission Make-up quantities are transferred into the atmosphere unless destroyed. Make-up quantities are transferred into the atmosphere unless destroyed. Make-up quantities are transferred into the atmosphere unless destroyed. Usage from 0.68t t to 0.62t t. Make-up quantities are transferred into the atmosphere unless destroyed. Usage from 0.68t t to 0.62t t. Make-up quantities are transferred into the atmosphere unless destroyed. Usage in range 0.2-0.3t t CTC MIC ; Source of information.
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