Pricing of pharmaceuticals in the UK is left entirely in the hands of the manufacturer. However, pharmaceutical profits are capped under the Pharmaceutical Price Regulation Scheme PPRS ; and the Government may intervene on an ad hoc basis if it believes that the PPRS is not sufficiently controlling the drugs bill. As a further control on the drugs bill, price rises for existing products must be agreed with Government. Full reimbursement of products is given to all products on launch unless they are subsequently blacklisted or have to be prescribed only under certain circumstances. A fixed patient prescription fee independent of the price of the product is payable, but this is a means tested payment and only occurs in around 15% of all prescriptions. Although collected by the pharmacist, this fee passes straight to Government and is no way part of the pharmacists' remuneration. Reimbursement prices for generic pharmaceuticals are published regularly in the Drug Tariff with reimbursement prices for branded products being published in the Chemist and Druggist Price List. Discounting is commonplace and so-called "brand equalisation" deals are also available, as is substitution by parallel-distributed products; pharmacists therefore usually pay a price for pharmaceuticals well below that published in the Tariff or Chemist and Druggist Price List. Pharmaceuticals are distributed through either community or hospital pharmacies. Community pharmacists purchase pharmaceuticals from wholesalers and parallel distributors usually on an "as and when" required basis. Community pharmacists can either be independent or part of a "Chain" e.g. Boots, Moss ; . Independent community pharmacy purchasing is fragmented and so they are less able to exercise collective purchasing power, although buying groups do exist to help in this area OXERA, 2001 ; . Hospital pharmacists are usually supplied directly via a manufacturer, although distribution is usually passed to a wholesaler. Contracts are issued for supplying pharmaceutical products and purchasing is largely centralised, and so therefore hospital pharmacies have been seen to use their collective purchasing power OXERA, 2001.
The Louisiana Office of Mental Health is seeking psychiatrists to work across the state in a variety of positions. We have a unique mental health care delivery system that is transforming itself in a number of ways to better meet the needs of our citizens. With the challenges we are facing from the 2006 hurricane season, our system has had to be creative and responsive. Come be a part of the recovery of our beautiful state! Positions are available in urban and rural areas, inpatient and outpatient facilities, and forensic and civil settings; adult and child psychiatrists are needed. For more information, please contact Kathleen Crapanzano, M.D., Office of Mental Health Medical Director, 628 PO Box 4049, Baton Rouge, LA 70821-4049 or phone at 225-342-2550 or e-mail at kcrapanz dhh.la.gov. DEPARTMENT OF PSYCHIATRY AND NEUROLOGY, TULANE UNIVERSITY SCHOOL OF MEDICINE in New Orleans, LA, is recruiting for several general and forensic psychiatrists clinical track ; for our growing department, at the Assistant Associate Professor level. Candidates must have completed an approved general psychiatry residency and be board certified eligible in general psychiatry and forensic psychiatry, respectively. Responsibilities will include direct patient care, teaching of medical students and house officers including those in our accredited forensic psychiatry fellowship program ; , and research clinical and basic science ; at various state hospitals, state correctional institutions, and at Tulane University Health Sciences Center. Time allocations will be based upon individual situations. Applicants must be eligible to obtain a Louisiana medical license. Applications will be accepted until suitable qualified candidates are found. Send CV and list of references to John W. Thompson, Jr., M.D., Vice Chair, Adult Psychiatry and Director, Division of Forensic Neuropsychiatry, Tulane University School of Medicine, Department of Psychiatry and Neurology, 1440 Canal Street TB53, New Orleans, LA 70112. For further information onsite, please contact Dan Winstead, MD, Chair of Psychiatry and Neurology, at 504-473-5246 or winstead tulane . Tulane is strongly committed to policies of nondiscrimination and affirmative action in student admission and in employment.
V. Tandon, G. Bano, V. Khajuria, A. Parihar, S. Gupta ABSTRACT Postgraduate Department of Pharmacology and Therapeutics, GMC, Jammu-180001 J&K ; India Received: 1.6.2004 Revised: 10.9.2004 Accepted: 10.10.2004 Correspondence to: Vishal Tandon E-mail: dr vishaltandon yahoo The lipid-lowering actions of statins are well known. However, recent studies provide compelling evidence that the clinical benefits of statin therapy may also be attributed to mechanisms independent of their cholesterol-lowering effects. These non-lipid-lowering pleiotropic ; effects of statin therapy are believed to include antiinflammatory actions, property to reverse endothelial dysfunction by decreasing LDL oxidation and increasing nitric oxide bioavailability. Their antioxidant actions, ability to provide plaque stability, favorable coagulation profile, ability to prevent platelet aggregation and normalize sympathetic outflow as well as their antiproliferative and immunosuppressive properties also contribute to the non-lipid-lowering effects. These pleiotropic effects shown by statin therapy offer many advantages over the currently available drugs for dyslipidemias. These additional benefits not only find therapeutic application in cardiovascular disorders but also in many other disease states. KEY WORDS: HMG CoA reductase inhibitors, immunomodulation, antioxidant, vascular disease, antiplatelet activity.
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Susceptible species. It is difficult to assess what level of gene transfer, if any, may be considered acceptable by the community. This is a significant reason to select strains lacking the potential to transfer genetic determinants of antibiotic resistance. Tests of bacteria to find a putative probiotic often yield conflicting data, sometimes for the same organism. Comparisons between studies and organisms cannot be readily made because of non-standardised dosing procedures, particularly for the number of bacteria and the duration of dosing. Pharmacokinetics, pharmacodynamics, safety and the risk of acquisition of antimicrobial resistance have usually not been evaluated 5. Probiotic effects are strain-specific, which illustrates the need to characterise the relationship between the dose, its duration and effect on a strain by strain basis. When considering of the the pharmacokinetics probiotic and bisoprolol.
Schering-Plough is committed to improving the health and well-being of people throughout the world. In fulfilling that commitment, we are developing new treatments and programs that assist patients in achieving their best possible therapeutic outcomes. In the United States, an important part of this effort involves helping patients through our patient assistance and patient support programs. Schering-Plough believes that the pharmaceutical industry needs to address the challenges facing low-income, chronically ill, underinsured and or other uninsured people who cannot access the prescription medicines they need to improve their health. We support efforts to increase access, and are committed to assisting patients in need to obtain treatment. We continuously evaluate our patient assistance programs for their ability to do the most good for the most people. We intend to maintain and, to the extent financially prudent, expand our programs.
A major aspect of a study by Arnhold and co-workers Arnhold et al., 1996 ; was to gain information on retinoid metabolism following consumption of liver. Ten male volunteers were given a light meal that included turkey liver 2 g raw weight kg body weight ; . Intake of retinol and retinyl esters ; from liver was determined to be approximately 3300 IU or 1 mg kg body weight. Major findings were the identification of two RA isomers, 9-cis-RA and 9, 13-di-cis-RA, as well as 14- hydroxy-4, 14-retroretinol 14-HRR ; in human plasma. The results are summarised in Table 2.2 and zebeta!
Alternatives In order to achieve the legislative intent to exclude from the expanded operation of Part XII.2 of the Criminal Code certain indictable offences, it is necessary that the Governor in Council, pursuant to subsection 462.3 2 ; of the Criminal Code, make regulations to identify the offences that are to be excluded from the definition of "designated offence". Benefits and Costs The expanded application of the proceeds of crime provisions of the Criminal Code to the proceeds of almost all indictable offences will significantly enhance the ability of law enforcement authorities to seize, restrain and forfeit the profits obtained by criminal activity. Expanding this application beyond offences.
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Carcinogenesis induced by N-nitrosodiethylamine and N-nitrosodimethylamine, respectively [ref: 2123]. C. Other relevant data No data were available on the genetic and related effects of ferric oxide in humans. It did not induce transformation of Syrian hamster embryo cells [ref: 24]. Overall evaluation Ferric oxide is not classifiable as to its carcinogenicity to humans Group 3 ; . Haematite is not classifiable as to its carcinogenicity to humans Group 3 ; . Underground haematite mining with exposure to radon is carcinogenic to humans Group 1 ; . For definition of the italicized terms, see Preamble Evaluation. Also see previous evaluation: Vol. 1 1972 ; References 1. IARC Monographs, 1, 29-39, 1972 Damber, L. & Larsson, L.-G. 1985 ; Underground mining, smoking, and lung cancer: a casecontrol study in the iron ore municipalities in northern Sweden. J. natl Cancer Inst., 74, 1207-1213 3. Edling, C. 1982 ; Lung cancer and smoking in a group of iron ore miners. Am. J. ind. Med., 3, 191-199 4. Edling, C. & Axelson, O. 1983 ; Quantitative aspects of radon daughter exposure and lung cancer in underground miners. Br. J. ind. Med., 40, 182-187 5. Ics, J. & Szllsov, M. 1984 ; The incidence of lung cancer in the miners of iron-ore mines Czech ; . Pracov. Lk., 36, 294-298 6. Jorgensen, H.S. 1973 ; A study of mortality from lung cancer among miners in Kiruna 19501970. Work Environ. Health, 10, 126-133 7. Jorgensen, H.S. 1984 ; Lung cancer among underground workers in the iron ore mine of Kiruna based on thirty years of observation. Ann. Acad. Med., 13 Suppl. ; , 371-377 8. Larsson, L.-G. & Damber, L. 1982 ; Interaction between underground mining and smoking in the causation of lung cancer: a study of nonuranium miners in northern Sweden. Cancer Detect. Prev., 5, 385-389 9. Radford, E.P. 1981 ; Radon daughters in the induction of lung cancer in underground miners. In: Peto, R. & Schneiderman, M., eds, Quantification of Occupational Exposure Banbury Report 9 ; , Cold Spring Harbor, NY, CSH Press, pp. 151-163 10. Radford, E.P. & St Clair Renard, K.G. 1984 ; Lung cancer in Swedish iron miners exposed to low doses of radon daughters. New Engl. J. Med., 310, 1485-1494.
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Supernatant were decanted out but at higher speed aggregation occurred which would ultimately affect the percent yield of capsule. In RBC core containing formulations the centrifugation speed was higher because the average size of RBC core is lower in comparison to calcium phosphate core. As well as density of LBL2 are less as compared to calcium phosphate cored which needed increased centrifugation speed producing average yield of 78.02% and 80% for the calcium cored and RBC cored alginate PAH capsules, respectively. Dissolution of the core resulted in capsules swelling and breaking due to difference in osmotic pressure. That is why core decomposition is the crucial step in the preparation of these hollow ultrathin hollow capsules. During the core decomposition process, the core was solubilized by lowering the pH to 1.4. The concentration of the ions in degradation products inside capsules becomes quite large. The generated osmotic pressure difference between the bulk and the capsule interior is equilibrated by a hydrostatic pressure difference, the later being responsible for the capsule expansion. The extent and duration of the osmotically induced tension on the capsule wall depends on the interplay between the speed of core dissolution and the permeation rate of the core decomposition products through the capsule walls. Naturally, a larger permeability would be favourable for releasing the tension. In the case of RBC core the percent intact capsule yield 80.18% ; obtained was more than calcium phosphate core 62.5% ; that is attributed to smaller capsule size 7.5 m and 4.2 m for LBL1 and LBL2, respectively ; having a higher stability against rupture. Indeed, at a given pressure difference P the tension in the wall becomes Pr 2, where r is the capsule radius. On the other hand, the halftime of the concentration decay is V AP 3P, where P is the wall permeability and V and A are capsule volume and surface area, respectively. Hence, it can be expected that capsules with smaller radii and otherwise the same wall properties should be more stable during the core dissolution process because of Laplace's law, where, when the tension is smaller, and the core degradation product concentration in the interior should decrease faster as a result of the more advantageous ratio between capsule volumes and surface 5 ; . This can also be attributed to the greater free ionic concentration in case of and captopril.
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Abstract. Objective: To conduct a systematic review of rigorously evaluated treatments for infant colic. Methods. Online bibliographic databases were searched for the term "colic" in articles classified as clinical trials or randomized controlled trials and conducted in infants. Reference lists from review articles, meta-analyses, and the selected articles were also reviewed for potential studies. The abstracts or full-text articles of 57 relevant studies were examined, of which 22 met the selection criteria. The methodology and findings of all retrieved articles were critically evaluated. Data were extracted from each article regarding study methods, intervention studied, outcomes measured, and results. Results. Four of the interventions studied had data of adequate quality and statistically significant numbers needed to treat NNT ; : hypoallergenic diet NNT 6 ; , soy formula NNT 2 ; , reduced stimulation NNT 2 ; , and herbal tea NNT 3 ; . Conclusions. There are some effective therapies for infant colic, but additional rigorous studies of existing and alternative therapies are needed. Pediatrics 2000; 106: 184 colic, treatment, infant, systematic review and diltiazem.
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Continued from page 1 or fatal injury from car crashes when driving while high. Inhalant use can cause damage to the heart, kidney, brain, liver and other organs. Signs and symptoms of inhalant use include chemical odors on breath or clothing; paint or other stains on face, hands or clothes; drunk or disoriented appearance; slurred speech; inattentiveness; lack of coordination; hidden empty spray paint or solvent containers; and chemical soaked rags or clothing. What can parents do? Put household products in a safe place and clearly mark them "poison." There are also simple, everyday things you can do to keep your kids away from drugs: Be absolutely clear with your children that you don't want them to use inhalants or other drugs. Don't leave room for interpretation. Talk often more than once or twice a year - about the dangers of drug and alcohol use. Don't react in a way that will cut off further discussion. If your child says things that challenge or shock you, respond with a calm discussion of why people use drugs and whether doing so is worth the risk.
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Els of calcium and phosphate in the abdominal aorta, kidney, nounced in the smaller branch arteries, such as the mesenteric, hepatic, and renal arteries. Microscopic examination of lung, small intestine, stomach, and trachea compared with the von Kossa-stained sections revealed massive calcification of levels seen in animals treated with vitamin D alone. In 4 of the elastic lamellae in the media of arteries from the vitamin these tissues, the levels of calcium and phosphate in the Dtreated animals and absence of staining in the arteries from animals treated with vitamin D plus osteoprotegerin were the animals treated with vitamin D plus osteoprotegerin figure same as those seen in age-matched control animals Table 2 ; , not shown ; . whereas in the stomach and trachea, the levels of calcium and Figure 3 shows the typical alizarin red staining seen in the phosphate found in the animals treated with vitamin D plus lungs of rats treated for 4 days with vitamin D alone and an osteoprotegerin remained above control levels. Calcium levexample of the absence of alizarin red staining seen in lungs els measured on serum obtained 96 hours after the first from the 4 rats treated with vitamin D plus osteoprotegerin at vitamin D injection were as follows: 14.6 0.5 mg dL for rats a dose of 1 mg kg per day. Microscopic examination of von treated with vitamin D only n 8 ; , 14.9 0.8 mg dL for rats Kossastained sections showed that calcification is associated treated with vitamin D plus osteoprotegerin n 8 ; , and with the alveolar wall and pulmonary arteries figure not 10.9 0.3 mg dL for untreated control rats n 4 ; . shown ; . As can also be seen in Figure 3, vitamin D treatment Sections of arteries, kidneys, lungs, small intestine, and caused increased calcification of tracheal ring cartilage, and the stomach were also stained by hematoxylin and eosin osteoprotegerin treatment prevented this increase. and examined. There was no evidence of cell necrosis or A repeat experiment was carried out to obtain a quantitadegeneration in any tissue from the animals treated with tive measure of the effects of treatment with vitamin D alone vitamin D plus osteoprotegerin, and the microscopic apand with vitamin D plus osteoprotegerin on the accumulation pearance of these tissues was indistinguishable from the of calcium phosphate mineral in arteries and other soft appearance of corresponding tissues from age-matched tissues. As shown in Table 2, treatment with vitamin D plus untreated control animals. Downloaded from atvb.ahajournals by on July 25, 2007 osteoprotegerin significantly P 0.001 ; decreased tissue lev.
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The median aPTT values in the acute phase of the FRIC trial were as follows Table 1 ; : TABLE 1. Median aPTT Values.
Affirmation of Faith Liturgist You are holy, O God of majesty, and blessed is Jesus Christ, your Son, our Lord. You sent him into this world to satisfy the longings of your people for a Savior, to bring freedom to the captives of sin, and to establish justice for the oppressed. He came among us as one of us, taking the lot of the poor, sharing human suffering. We rejoice that in his death and rising again, you set before us the sure promise of new life, the certain hope of a heavenly home where we will sit at table with Christ our host. Response 579 Glory be to the Father tune: GLORIA PATRI.
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