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Convexity and falcine meningiomas are easily treated using conventional open surgical techniques. Modern anesthesia combined with meticulous surgical techniques may result in high rates of gross total surgical resection with minimal morbidity and mortality Figure 2 ; . For these lesions, open surgical treatment remains the preferred treatment for patients with low medical risk. Various lesions of the skull base present substantially higher overall operative risk. Most tumors located in this region are intimately associated with critical nervous and vascular structures; therefore, attempts at total resection carry substantial risk of morbidity to these nerves. Published surgical series7, 8 have shown relatively high rates of cranial nerve palsy as well as leakage of cerebrospinal fluid and high risk of tumor recurrence. Because of these risks, radiosurgery has become an increasingly attractive alternative to microsurgical resection for lesions located at the skull base. Published series9 have described radiosurgical management of these lesions and have shown excellent overall tumor.
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Systems, Division of Marion Laboratories, Kansas City, MO, 1983. 3. MacCarthy EP, Bloomfield SS. Labetalot: A review of its pharmacology, pharmacokinetics, clinical uses and adverse effects. Phar, nacotherapy 3, 193-219 1983 ; . Fi-ed S. Apple Mary Kay Googins Steve Kastner Karen Nevala Steve Edmondson Julie Kioss Clin. Labs. Hennepin Co. Med. Ctr. 701 Park Ave. South Minneapolis, MN 55415.
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55. Chu KC, Tarone RE, Kessler LG, et al: Recent trends in U.S. breast cancer incidence, survival, and mortality rates. J Natl Cancer Inst 88: 1571-1579, 1996 Ron E: Thyroid cancer, in Schottenfeld D, Fraumeni JF eds ; : Cancer Epidemiology and Prevention ed 2 ; . New York, NY, Oxford University Press, 1996, pp 546-558 57. McTiernan AM, Weiss NS, Daling JR: Incidence of thyroid cancer in women in relation to reproductive and hormonal factors. J Epidemiol 120: 423-435, 1984 Preston-Martin S, Bernstein L, Pike MC, et al: Thyroid cancer among young women related to prior thyroid disease and pregnancy history. Br J Cancer 55: 191-195, 1987 Ron E, Kleinerman RA, Boice JD, et al: A population-based case-control study of thyroid cancer. J Natl Cancer Inst 79: 1-12, 1987 Paoff K, Preston-Martin S, Mack WJ, et al: A case-control study of maternal risk factors for thyroid cancer in young women California, United States ; . Cancer Causes Control 6: 389-397, 1995 Preston-Martin S, Jin F, Duda MJ, et al: A case-control study of thyroid cancer in women under age 55 in Shanghai People's Republic of China ; . Cancer Causes Control 4: 431-440, 1993 Cheng L, Neumann RM, Blute ML, et al: Long-term follow-up of untreated state T1a prostate cancer. J Natl Cancer Inst 90: 1105-1107, 1998 Henderson BE, Ross RK, Pike MC, et al: Endogenous hormones as a major factor in human cancer. Cancer Res 42: 3232-3239, 1982 Henderson BE, Ross RK, Bernstein L: Estrogens as a cause of human cancer: The Richard and Hinda Rosenthal Foundation award lecture. Cancer Res 48: 246-253, 1988 Key TJA, Pike MC: The dose-effect relationship between "unopposed" estrogens and endometrial mitotic rate: Its central role in explaining and predicting endometrial cancer risk. Br J Cancer 57: 205212, 1988 Weiss NS, Szekely DR, Austin DF: Increasing incidence of endometrial cancer in the United States. N Engl J Med 294: 1259-1262, 1976 The Cancer and Steroid Hormone Study of the Centers for Disease Control and the National Institute of Child Health and Human Development: Combination oral contraceptive use and the risk of endometrial cancer. JAMA 257: 796-800, 1987 Henderson BE, Casagrande JT, Pike MC, et al: The epidemiology of endometrial cancer in young women. Br J Cancer 47: 749-756, 1983 Weiss NS, Sayvetz TA: Incidence of endometrial cancer in relation to the use of oral contraceptives. N Engl J Med 302: 551-554, 1980 Henderson BE, Ross RK, Pike MC: Hormonal chemoprevention of cancer in women. Science 259: 633-638, 1993 El-Serag HB: Rising incidence of hepatocellular carcinoma in the United States. J Natl Cancer Inst 340: 745-750, 1999 Yu MC, Tong MJ, Govindarajan S, et al: Nonviral risk factors for hepatocellular carcinoma in a low-risk population, the non-Asians of Los Angeles County, California. J Natl Cancer Inst 83: 1820-1826, 1991 Recommendations for prevention and control of hepatitis C virus HCV ; infection and HCV-related chronic disease. MMWR Morb Mortal Wkly Rep 47: 1-39, 1998 RR-19 ; 74. Di Bisceglie AM: Hepatitis C and hepatocellular carcinoma. Hepatology 26: 34S-38S, 1997 suppl 1 ; 75. Di Bisceglie AM, Goodman ZD, Ishak KG, et al: Long-term clinical and histopathological follow-up of chronic posttransfusion hepatitis. Hepatology 14: 969-74, 1991!
And used for SAR studies include atomic molecular connectivity index, 31 eccentric adjacency topochemical index, 32 Wiener's topochemical index33 and superadjacency topochemical index34 etc. In the present study, adjacency based Zagreb indices M1 and M2 have been refined and the corresponding Zagreb topochemical indices have been proposed. The discriminating power and degeneracy of the newly proposed Zagreb topochemical indices has been investigated and compared with the original indices. The relationship of these indices with anti-inflammatory activity of N-arylanthranilic acid derivatives has been investigated and suitable models for the prediction of anti-inflammatory activity have been developed. Zagreb Indices M1 and M2. This pair of indices was introduced in 1972 Ref. 35 ; and were given different names in the literature, such as the Zagreb Group indices, the Zagreb group parameters and most often, the Zagreb indices. These indices are denoted by M1 and M2 and are defined as per the Eqs. 1 ; and 2 ; . M1.
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Exhibit 3.6: Comparison between private retail sector pharmacies and dispensing doctor sector.
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Aebi H. 1983 ; : Catalase in vitro. Methods Enzymol. 105, 121--126 Balabolkin M. I., Mamaeva G. G., Poliakova I. A., Kniazeva A. P. 1992 ; : Use of the lipolytic drug mevacor in the treatment of patients with diabetes mellitus. Probl. Endokrinol. Mosk ; 38, 34--35 Russian ; Baynes J. W., Thorpe S. R. 1999 ; : Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes 48, 1--9.
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