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Lying diseases that may precipitate heart failure ; , neurohormonal blockade, hemodynamic therapy, antiarrhythmic therapy, and lifestyle modification. Almost all available studies of pharmacotherapy for heart failure have evaluated patients with systolic dysfunction; thus, our discussion will focus primarily on these patients. When normal systolic function is preserved, therapy for heart failure should be directed at the underlying disease process eg, hypertension or ischemia ; and at symptom eg, fluid retention or arrhythmia ; control. PREVENTION The development of CHF often begins with an insult to the myocardium that initiates the process of ventricular remodeling. See "The pathophysiology of congestive heart failure" on page 770. ; The best way to treat heart failure is to prevent its occurrence by managing the diseases eg, hypertension, diabetes mellitus, and coronary artery disease [CAD] ; that increase CHF risk. Hypertension and diabetes mellitus are important risk factors for CHF, especially in women; thus, every effort should be made to control these conditions. With aggressive treatment of hypertension including systolic hypertension in elderly patients ; , the incidence of CHF can be decreased by up to 50%.3 The treatment of hypertension should be even more aggressive in the presence of diabetes mellitus.4.
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Votes are taken by a show of hands unless the shareholders' meeting resolves to have a ballot or such ballot is ordered by the chairman of the meeting. Net Profit and Dividends Swiss law requires that at least 5% of the annual net profits of a corporation be retained as general reserves for so long as these reserves amount to less than 20% of the corporation's registered share capital. The articles of a corporation may provide for further mandatory reserves. The Articles of the Company do not contain any such provision for further reserves. Under Swiss law, dividends may be paid out only if the Company has sufficient distributable retained earnings from previous business years, or if the reserves of the Company are sufficient to allow distribution of a dividend. In either event, dividends may only be paid out after approval by the shareholders' meeting. The Board of Directors may propose that a dividend be paid out, but cannot itself set the dividend. The auditors must confirm that the dividend proposal of the Board conforms with the Swiss Code of Obligations and the Articles. In practice, the shareholders' meeting usually approves the dividend proposal of the Board of Directors. The Board of the Company intends to propose a dividend once a year. See ``Item 8. Selected Financial Data--Cash Dividends per Share''. Dividends are usually due and payable immediately after the shareholders' resolution relating to the allocation of retained earnings has been passed. Under Swiss law, the statute of limitations in respect of dividend payments is five years. For information about deduction of the Withholding Tax, see ``Item 7. Taxation''. Preemptive Rights Under Swiss law, any issuance of shares, whether for cash or non-cash consideration or for no consideration at all, is subject to prior approval of the shareholders' meeting. Shareholders of a Swiss corporation have certain preemptive rights to subscribe for newly issued shares in proportion to the nominal value of the shares they already hold. A resolution adopted at a shareholders' meeting with a supermajority may, however, limit or suspend preemptive rights in certain limited cases. Borrowing Power Neither Swiss law nor the Articles restrict in any way the Company's power to borrow or raise funds. The decision to borrow funds is taken by or under the direction of the Company's Board of Directors, and no shareholders' resolution is required. Conflict of Interests Swiss law does not have a general provision on conflicts of interests. However, the Swiss Code of Obligations requires directors and members of senior management to safeguard the interests of the corporation and, in this connection, imposes a duty of care and a duty of loyalty on such persons. This rule is generally interpreted to mean that directors and members of senior management are disqualified from participating in decisions which affect them personally. Directors and officers are personally liable to the corporation for any breach of these provisions. In addition, Swiss law contains a provision under which payments made to a shareholder or a director or any other persons associated with them, other than payments at arm's length, must be repaid to the corporation if the shareholder or director was acting in bad faith. Repurchase of Shares Swiss law limits a corporation's ability to hold or repurchase its own shares. Therefore, the Company and its subsidiaries may only repurchase Shares if the Company has sufficient free reserves to pay the.
Magazine advertisement, it's hard to accept the adequacy of the soothing TV voice-over blandly indicating that a product "is not for everyone." Healthcare is a critically important cost element for American businesses. Forecasts indicate that it could consume 20% of GDP if current cost trends continue. America vastly overpays for the healthcare it receives! Creative solutions need to be considered to address the many causes of this rapidly growing expense. One solution is to provide consumers a higher level of ethics from companies that deal with our personal mortality! s Curtis C. Verschoor is the Ledger & Quill Research Professor, School of Accountancy and MIS, and Wicklander Research Fellow in the Institute for Business and Professional Ethics, both at DePaul University in Chicago. He is also a Research Scholar in the Center for Business Ethics at Bentley College in Waltham, Mass. His e-mail address is curtisverschoor sbcglobal.
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This material contains an active pharmaceutical ingredient with octanol water partition coefficient data that suggests that for environmental fate predictions the active pharmaceutical ingredient will not have the tendency to distribute into fats. This material contains an active pharmaceutical ingredient that has been shown to be chemically stable in water. Hydrolysis is unlikely to be a significant depletion mechanism. Half-Life, Neutral: 1 Months, Measured, Deionized Water This material contains an active pharmaceutical ingredient that has been shown to be chemically unstable in water when exposed to light. Aqueous photolysis may be a significant depletion mechanism. Half-Life, Aqueous: UV Visible Spectrum: 2 to 200 Hours, Measured, Lake water 216 nm at pH.
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