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Had active rheumatoid arthritis despite at least 6 months of methotrexate therapy, including stable dosage for at least 8 weeks. Patients with active rheumatoid arthritis were defined as meeting three of the following criteria on two different evaluations, 7 to 21 days apart: at least nine tender joints, at least six swollen joints, at least 45 minutes of morning stiffness, and an erythrocyte sedimentation rate of at least 28 mm h. Previous disease-modifying antirheumatic drugs, not including ongoing methotrexate, had failed in 11 patients. Patients receiving corticosteroids were required to have been taking a stable daily dose of 10 mg or less for at least 30 days before study drug administration, and the corticosteroid dose was required to remain constant throughout the study. Complete exclusion criteria are listed in Appendix Table 1, available at annals.
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Figure 2. Tissue corresponding to the ischemic penumbra was dissected for Western blot. Ischemic lesion in a normothermic rat is represented as black plus gray, and black alone represents ischemic infarct in a hypothermic rat. The region spared by hypothermia is defined as the penumbra gray ; , and the black area is the ischemic core. The region of the penumbra within the solid lines, I ; was dissected for Western blotting. The corresponding contralateral nonischemic cortex II ; or similar cortex from sham animal without ischemia was dissected as a control. stroked until they relaxed and the trial was resumed. The percentage of vibrissa stimulations in which a paw placement occurred was calculated. Postural reflex test. Postural reflexes were assessed using a method modified from Bederson et al. 1986 ; . The animal was placed on a table, and its tail was held by one hand while the other hand gently pushed the animal's shoulder, moving it laterally 20 cm. The test was repeated in the opposite direction. This process was repeated several times. The use of the forelimbs to resist the lateral movement was scored. Normal, nonischemic rats gripped the table and braced frequently during the push, which was scored as 0. The contralateral forelimb of an ischemic rat may show less resistance and become stiff during the push, which was scored as 1. If the forelimb offered no resistance, i.e., did not brace and dragged under the body during the push, this was scored as 2. Tail hang test. Tail hang test was performed at 30 and 60 d after stroke as described by Borlongan et al. 1998 ; with slight modification. The rat was lifted 510 cm above the table. An ischemia-damaged rat will immediately turn to the contralateral right ; side. This large right turn is accompanied by a twisting of the body and usually a raising of the head toward the holding hand. "Turns" were counted when the angle reached 90 or more. Smaller turns were not counted. The rat was lifted no more than 5 s on each trial and was released for a few seconds before the next trial. The test was repeated 20 times each testing day. The percentage of trials on which a right turn occurred was calculated. Home cage limb use test. After completing the other behavior tests, the animal was returned to its home cage. Rats usually rear up and explore the wall of the cage Schallert et al., 2000 ; . We counted the number of times the animal used its forelimbs to brace itself against the wall, counting separately for the ipsilateral, contralateral, or both forelimbs, until 20 and tetracycline.
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Physiol 47, 990-1001. Wilson, T. A. 1981 ; J. Appl Physiol, 50, 222-224. Pattle, R. E. 1958 ; Proc. R. Soc. London Ser. B 148, 217-240. Clements, J. A. 1961 ; Arch. Environ. Health 2, 280-283. Guyton, A. C. & Moffatt, D. S. 1981 ; Prog. Resp. Res. 18, 62-75. Staub, N. C. 1980 ; Prog. Cardiovasc. Dis. 32, 53-80. Snashall, P. D. & Hughes, J. M. B. 1981 ; Rev. Physiol Biochem. Pharmacol. 89, 5-62. 9. Olver, R. E., Ramsden, C. A. & Strang, L. B. 1981 ; 1. Physiol London ; 319, 38P-39P. 10. Matthay, M. A., Landolt, C. & Staub; N. C. 1982 ; J. Appi. Physiol 53, 96-104. 11. Lever, J. E. 1979 ; J. Supramol Struct. 12, 259-272 and voltaren.
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Apathy is common in HD and is probably related to frontal lobe dysfunction. Apathetic patients become unmotivated and uninterested in their surroundings. They lose enthusiasm and spontaneity. Performance at work or school becomes sluggish. The symptom of apathy can be very troubling to families, if they see the active person they knew slipping away. It can be a source of conflict for caregivers, who know the person is physically capable of activities but "won't" do them. Families need much education and support in this regard and should learn to practice a combination of exhortation and accommodation. While apathetic patients have trouble initiating actions, they will often participate if someone else suggests an activity and works along with them to sustain energy and attention. For example, a man with HD had always loved fishing, but when his brother came to take him fishing for his birthday he wanted to stay home in front of the television. The brother insisted, and when they left the house, he had a good time fishing all day. When he returned, he immediately turned the television back on. Apathy can be hard to distinguish from depression. Apathetic patients, like those with depression, may be sluggish, quiet, and disengaged. They may talk slowly, or not at all. By and large apathetic patients will deny being sad, but in distinguishing the two it is important to ask not only about the patient's mood, but about other depressive symptoms as well, such as a change in sleeping or eating patterns, feelings of guilt, or suicidal thoughts. Neuroleptics and benzodiazepines can cause or worsen apathy. The need for these medications should be reexamined if the patient is apathetic. TABLE 17: COPING STRATEGIES FOR APATHY Use calendars, schedules and routines to keep the person busy. Do not interpret lack of activity as "laziness." Patients may not be able to initiate activities, but may participate if encouraged by others. Gently guide behaviors, but accept "no and terbinafine.
Bradley Pharmaceuticals, Inc. and Subsidiaries NOTES TO CONSOLIDATED FINANCIAL STATEMENTS December 31, 2002 NOTE N - QUARTERLY FINANCIAL INFORMATION UNAUDITED ; The table below lists the quarterly financial information for fiscal 2002 and 2001. All figures in thousands, except per share amounts, and certain amounts do not total the annual amounts due to rounding.
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The suppurative, erythematous inflammation of cellulitis can occur in any area of the body. There are many organisms that cause cellulitis Table 1 ; . The differential diagnosis for cellulitis includes erythema nodosum, erythema gangrenosum, insect bites, dermatitis, or Well's syndrome.1 The skin margins of cellulitis are usually poorly demarcated, except for erysipelas, which has sharply demarcated borders. The erythematous region may become nodular and vesicular, which can rupture to reveal pyopoietic and necrotic material Table 2 ; .2 The disease may involve males more than females and more commonly involves the lower extremities.3 There are risk factors associated with developing cellulitis, specifically sites of entry trauma, intertrigo ; , venous insufficiency, peripheral edema, lymphedema, tinea pedis, and obesity.4, 5 Complications resulting from cellulitic infec.
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[1] S. Abad-Mota. Approximate Query Processing with Summary Tables in Statistical Databases. In EDBT, pages 499 515, Vienna, Austria, Mar. 1992. [2] S. Acharya, P. B. Gibbons, V. Poosala, and S. Ramaswamy. Join Synopses for Approximate Query Answering. In ACM SIGMOD, pages 275286, Philadelphia, PA, USA, June 1999. [3] A. Arning, R. Agrawal, and P. Raghavan. A Linear Method for Deviation Detection in Large Databases. In International Conference on Knowledge Discovery and Data Mining, pages 164169, Portland, OR, USA, Aug. 1996. [4] D. Barbar and M. Sullivan. Quasi-Cubes: Exploiting Apa proximations in Multidimensional Databases. 26 3 ; : 1217, 1997. [5] D. Barbar and X. Wu. Using Loglinear Models to Compress a Datacubes. In Web-Age Information Management, pages 311322, Shanghai, China, June 2000.
In recent years, the creation of new cephalosporins for parenteral and oral use has made it difficult for clinicians to remember the names and clinical uses of the drugs.
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