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Persistently elevated expansive irritable mood. Associated features: over talkativeness, grandiosity, distractibility, diminished need for sleep, racing thoughts, unrealistic plans and disturbed social functions. Conditions, six of the eight subjects had predicted serum concentrations that considerably exceeded the upper end of the therapeutic range; they would therefore have been at risk for toxic effects from the of 29 are biofood-induced There are theophylline different available regulatory availability there has on absorption the gree plain Theo-Dur Pulmo-dur ; , # bid Gyrocaps Somophyllin-CRT in the tant Theolair appears vitro.3' absorption creased Sprinkle ing, but following absorption the rate effects on limited without uncoated absorption brand in the "dose-dumping." at least 16 slow-release available names; United in the some Kingdom have United of these and required.

These 3 adolescent males all developed an acute syndrome of gait instability, headache, cerebellar dysfunction, altered mental status, and variable dysphagia dysarthria, with evidence of brainstem dysfunction in the 2 subjects who died Table 1 ; . The clinical and pathologic findings in all 3 cases were related to ischemic infarction in the distribution of multiple distinct cerebellar arterial vessels, which were primary and specifically unrelated to cerebellar herniation from any supratentorial process. The neuropathology did not identify primary tonsillar herniation, which would have been present in a supratentorial process such as diffuse hypoxic-ischemic encephalopathy. Each of the 3 cannabis-associated cases of cerebellar infarction was confirmed by biopsy 1 case ; or necropsy 2 cases ; and showed inflammatory cellular reactions characteristic of a 1- to 3-day-old infarct case 1 ; or a 3- 7-day-old infarct cases 2 and 3 ; .3 In all 3 cases, the central nervous system infarction was acute and localized to cerebellum. Multiple cerebellar arterial distributions were involved in the 3 cases. Brainstem compromise caused by cerebellar and cerebral edema led to death in the 2 fatal cases. For a.
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These are both medicines called nucleoside reverse transcriptase inhibitors.

3 2 THEO-DUR 450MG TABLET SA THEOLAIR-SR 300MG TABLET THEOPHYLLINE 100MG TAB SA THEOPHYLLINE 200MG CAP SA THEOPHYLLINE 200MG TAB SA THEOPHYLLINE 300MG CAP SA THEOPHYLLINE 300MG TAB SA THEOPHYLLINE 450MG TAB SA THEOPHYLLINE 80MG 15ML SOLN THERMAZENE 1% CREAM THEROBEC PLUS TABLET THIORIDAZINE 100MG TABLET THIORIDAZINE 10MG TABLET THIORIDAZINE 15MG TABLET THIORIDAZINE 25MG TABLET THIORIDAZINE 50MG TABLET THIOTHIXENE 10MG CAPSULE THIOTHIXENE 1MG CAPSULE THIOTHIXENE 2MG CAPSULE THIOTHIXENE 5MG CAPSULE THORAZINE 100MG TABLET THORAZINE 10MG TABLET THORAZINE 150MG TABLET THORAZINE 200MG TABLET THORAZINE 25MG TABLET THORAZINE 50MG TABLET THYROID 120MG TABLET THYROID 60MG TABLET THYROLAR-1 TABLET THYROLAR-1 4 TABLET THYROLAR-2 TABLET THYROLAR-3 TABLET TIAZAC 120MG CAPSULE SA TIAZAC 180MG CAPSULE SA TIAZAC 240MG CAPSULE SA TIAZAC 300MG CAPSULE SA TIAZAC 360MG CAPSULE SA TIAZAC 420MG CAPSULE SA TICLID 250MG TABLET TICLOPIDINE 250MG TABLET TIGAN 100MG CAPSULE TIGAN 100MG SUPPOSITORY TIGAN 200MG SUPPOSITORY TIGAN 250MG CAPSULE TIKOSYN 0.125MG CAPSULE TIKOSYN 0.25MG CAPSULE TIKOSYN 0.5MG CAPSULE TILADE INHALER TIMOLOL 0.25% EYE DROPS TIMOLOL 0.25% GEL SOLUTION TIMOLOL 0.5% EYE DROPS TIMOLOL 0.5% GEL SOLUTION TIMOLOL MALEATE 10MG TABLET TIMOPTIC 0.25% EYE DROPS TIMOPTIC 0.5% EYE DROPS TIMOPTIC-XE 0.25% EYE SOLN TIMOPTIC-XE 0.5% EYE SOLN TINDAMAX 250MG TABLET TINDAMAX 500MG TABLET TIZANIDINE 2MG TABLET TIZANIDINE 4MG TABLETS TOBI 300MG 5ML SOLUTION TOBRADEX EYE DROPS TOBRADEX EYE OINTMENT TOBRAMYCIN 0.3% EYE DROPS TOBREX 0.3% EYE DROPS TOBREX 0.3% EYE OINTMENT TOFRANIL 25MG TABLET TOFRANIL 50MG TABLET TOFRANIL-PM 100MG CAPSULE TOFRANIL-PM 125MG CAPSULE TOFRANIL-PM 150MG CAPSULE and ventolin.

Antibiotics Pure theophylline preparations e.g. Slo-Bid, Uniphyl, Theo-24, Theo-Dur ; Bronchodilator inhalers e.g. Proventil, Ventolin, Serevent, Maxair, Albuterol, Atrovent, Foradil, etc. ; Cromolyn sodium e.g. Intal ; and nedocromil sodium e.g. Tilade ; Singulair. Each tamiflu pill contains 75mg of the active ingredi theobid theophylline , theo-dur , uniphyl ; used to prevent and treat wheezing, shortness of breath, and difficulty breathing caused by asthma, chronic bronchitis, emphysema, and other lung diseases and cimetidine.

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E. Pufal, M. Sykutera, P.Piotrowski Katedra i Zaklad Medycyny S dowej UMK w Toruniu Collegium Medium Bydgoszcz , ul.Marii Sklodowskiej Curie 9, 85-094 Bydgoszcz, Polen The analysis of the fatal poisonings investigated at the Institute of Forensic Medicine of the Collegium Medicum in Bydgoszcz in the years 1996 2006 is described. The last ten years are characterized by a great dynamics concerning the number deadly poisoned people and the kind of xenobiotics causing the deaths. Between the years 1996 and 2006, the total of 1500 postmortem chemical toxicological examinations were performed. The structural changes between particular groups of poisoning in the period of time concerned ethanol, carbon monoxide, drugs and others cyanides, toxic anions, rat-poison, narcotic, organic solvents.

It is said that that medicine has anti-inflammatory affects also, so one can not draw certain conclusions yet and differin. Women clear the drug more slowly than men.

Vegetable products Live trees and other plants; bulbs, roots and the like; cut flowers and ornamental foliage Articles admitted without conditions. Edible vegetables and certain roots and tubers and eldepryl. DisCUSSION Post-rotational Turning Sensation. - The mean records obtained from the group of subjects on each day of the test afford clear evidence of a response decline. This is probably largely attributable to habituation processes which are akin to the 'tolerance' which develops on repeated exposures to other forms of unfamiliar labyrinthine stimulation [Hallpike and Hood, 1953; Glaser and McCance, 1959; Guedry, 1965]. Groen [1962] attributed such response decline to an adaptive change in the 'coupling' between the vestibular afferent signal and the neuronal centres which control the efferent manifestations of such signals. It may also be partly due to the decrease in mental arousal which develops as the experimental situation becomes inDownloaded from ep.physoc by on September 20, 2007. Benign, since the patient was told it should be biopsied, it is better to do the biopsy than upset the patient" [2]. Others would argue that to perform a surgical procedure without sound medical justification is assault and battery, to say nothing of a departure from good medidine, standard of care, and morally connect on ethical practice. Our policy, relating to the issue raised by this question and supported by the experience of others [2], has evolved after many fnustrations, canceled surgical procedures, and unnecessary expense to and feldene.
Effectively, increasing the working concentration of the product changes the use for which it is applicable. When used as a fish medication, it is used at low doses in milligrams per litre ; whereas much higher concentrations are required for disinfection in the order of kilograms per 100 litres water ; . Over the years, more information has emerged about the diverse uses for Halamid, its safety and its lack of damage to the environment. Mode of action In solution, the chloramine-T ion is formed. This is the active ingredient, which reacts with cellular material. It is an irreversible oxidative reaction and consequently, it is not possible for microbes to adapt or develop resistance. It does not form hypochlorous acids as stated in some literature, nor does it rely on the formation of free, reactive oxygen or chlorine radicals. It acts through the formation of the chloramine-T ion in solution which then reacts with the organic material with which it comes into contact. The compound is a relatively poor `chlorine donor' and does not form organochlorines in the environment. Factors affecting biocidal activity Concentration Contact-time Temperature pH Water hardness Organic load Additives ie foaming agents ; Effect of pH Fig 1 demonstrates the stability of the product over a range of different pH conditions. Halamid reacts faster in acidic environments and this may be beneficial in some cases, an attribute that can be adjusted to suit individual circumstances. However, this may be more difficult to achieve in aquaculture than in land-based operations because of the additional constraints of the environment.
Generic competition one of the biggest competitive challenges that the company faces in the united states and internationally is from generic pharmaceutical manufacturers and frusemide. Doctor didn't think it was from the drug.

Prezzo e costi di spedizione: 58 48 per I soci SHI ; ? Costi di spedizione: nessuno per l'Italia; da definire per l'estero. Prices and shipping costs: 58 48 to SHI members ; ? Shipping costs: Italy - free; other countries: to establish. Le ordinazioni saranno prese a partire dal mese di Luglio 2007 direttamente dall'editore Orders will be accepted from July 2007 by the publisher: Edizioni Belvedere di Luigi Corsetti, via Adige 45 Latina Italia ; : edizionibelvedere.it email: info edizionibelvedere.it and keflex. 57 ; Abstract: Described herein are novel drug compositions for oral and or mucosal buccal, sublingual, nasal, pulmonary, etc. ; administration comprising a plurality of polymeric, nanoparticles made from pharmaceutically acceptable bioadhesive polymers and active drug selected from group of proteins ad peptides such as insulin, other macromolecules such as nucleic acids and other biologically active molecules. The invention further relates to absorption enhancers for use in above composition for enhanced absorption of drug by oral and or mucosal membrane. Drawing: 02 Sheets. Total Pages: 24. Fig. Nil. Stantially increased with the combination versus either modality alone. Gleason score, PSA, and the findings on digital rectal examination and imaging would be the main considerations in determining whether the patient is at sufficient high risk to warrant combination therapy. Further progress may be attainable by combining the 3 modalities of androgen ablation, chemotherapy and radiation therapy, although again the toxicity will be significantly increased as well. A quality of life component should be incorporated into studies of combination modalities and also considered in the benefit risk assessment of the individual patient's treatment. The role of adjuvant therapy in the high risk population following either surgery or radiotherapy needs systematic study. A substantial proportion of these patients may be presumed to have micrometastases at presentation; micrometastases are more susceptible to hormonal or chemotherapy eradication than established bulky disease. High risk patients can be identified by clinical, biochemical or molecular techniques, providing a sufficiently well-defined target population for testing adjuvant treatment. The efficacy of adjuvant chemotherapy is well established for other common epithelial cancers eg with survival benefit in lung, colorectal, breast ; . The Southwest Oncology Group 9921 trial is attempting to examine this question but is currently accruing slowly. A major disconnect between clinical guidelines and clinical practice lies in the status of primary hormone therapy for nonmetastatic prostate cancer. In the United States, and even more so in Japan where it is the treatment of choice, men with locally advanced or localized prostate cancer often receive androgen ablation therapy as primary treatment. There are few prospective data to indicate whether androgen ablation is effective as a primary treatment with surgery or radiation. Some recent data, discussed by Akaza et al page 000 ; in this issue, suggest that the efficacy of androgen deprivation is greater in early stage prostate cancer than in late stage disease, where its effects are generally palliative. In Japan a large, prospective study of more than 26, 000 patients is now under way evaluating progression-free survival, overall survival and cancer specific survival in patients receiving androgen deprivation as primary, adjuvant or neoadjuvant therapy. If this and other trials provide evidence of disease control, clinical guidelines for early stage prostate cancer should be revised to include primary androgen deprivation as an option. Once again, however, the morbidity of this treatment requires careful study. Neoadjuvant therapy is another option for patients diagnosed with high risk local regional disease. Currently, there are 2 randomized trials, the Veterans Administration CSP 553 and Cancer and Leukemia Group B 90203 studies, looking at neoadjuvant hormones plus chemotherapy versus none, examining outcomes in terms of local and systemic control. MANAGEMENT OF HIGH RISK RECURRENT DISEASE As noted, not all PSA failures following local treatment indicate high risk, and treating them all may mean unnecessary exposure to toxicity. PSADT has better usefulness in assessing the risk and the appropriate manage and nifedipine.
The usual dose is one 20 mg tablet to be taken once daily in the morning before breakfast. Theophylline ElixophyllinR, QuibronR-T, RespbidR, Slo-PhyllinR, TheochronR, TheoclarR, Theo-DurR, TheolairR, Theo-24R, UniphylR ; Mechanism of Action: Inhibits phosphodiesterase producing increased tissue concentrations of cyclic adenosine monophosphate cAMP ; . This results in: bronchodilation, CNS stimulation, positive inotropic and chronotropic effects, diuresis, gastric acid secretion. Indications: Used as a bronchodilator in long-term control of reversible airway obstruction caused by asthma or COPD. Stimulant in apnea of infancy. Adverse Effects and Side Effects: CNS: Seizures, anxiety, headache, insomnia, tremor CV: Arrythmias, tachycardia, angina, palpitations GI: Nausea, vomiting, anorexia, abdominal cramps Drug Interactions: Additive cardiovascular and CNS side effects with sympathomimetic and reminyl and theo-dur.
Hubbard's hate campaign ron hubbard, founder of scientology, began expounding his theories about the source and cure of all mental illness in his earliest science fiction articles as well as his first book — dianetics: 'the modern science of mental health — still considered scientology's bible, according to louis jolyon jolly ; west professor and former chair of the psychiatry and biobehavioral department at ucla.
Introduction Numerous studies of rodent cancer models and in humans show that nonsteroidal anti-inflammatory drugs NSAIDs ; have antineoplastic properties. One known effect of NSAIDs is their ability to inhibit the key enzymes required for prostaglandin production prostaglandin endoperoxide synthase or cyclooxygenase ; . Two isoforms of cyclooxygenase have been characterized, COX-1 and COX-2. Most of the preclinical evidence for the antineoplastic effects of NSAIDs is based on studies using animals that have either a genetic or a chemically induced predisposition to develop colon cancer 1 ; . These type of experimental approaches lack the power to determine whether the antineoplastic effects of NSAIDs are specifically due to inhibition of cyclooxygenase, the result of other effects, or both. Oshima et al. 2 ; evaluated COX-2 mice to determine whether COX-2 contributed to adenoma formation. They found that when mice with a genetic predisposition for polyp formation were mated with COX-2 mice, tumor burden in the offspring was significantly reduced when compared with that of control mice, strongly implicating a role for COX-2 in tumor promotion. Others have shown that treatment with COX-2 inhibitors leads to a marked reduction in the growth of a variety of neoplasms including colon 3 ; , head and neck 4 ; , skin 5 ; , and bladder 6 ; . Recent clinical studies have indicated that the presence of COX-2 in human and selegiline.
13. Kashyap S and Claman P. Polycystic Ovarian Disease and the Risk of Pregnancy-Induced Hypertension. Journal of Reproductive Medicine 2000; 45: 991- Kashyap S and Gruslin A. Maternal Influenza Vaccination. Primary Care Update for Obgyns 2000; 7: 7-11. Lear W, Mc Donald M, Kashyap S and Boer P. Random Primer p dN ; 6 digoxigenin labeling for quantitation of mRNA by Q-RT-PCR and ELISA. Biotechinques 1995; 18 1 ; : 7880, 82-83.

Department of Molecular Medicine M.H., P.E., L.P., I.U. ; , National Public Health Institute, FIN-00290 Helsinki, Finland; Hospital for Children and Adolescents M.H., P.E., Ja.P. ; , Helsinki University Hospital, FIN-00290 Helsinki, Finland; Department of Pediatrics A.-G.M. ; , Akershus Central Hospital, N-1474 Nordbyhagen, Norway; Division of Endocrinology A.-G.M., E.S.H. ; , Institute of Medicine, Haukeland University Hospital, N-5021 Bergen, Norway; Department of Clinical Sciences O.K., F.R. ; , University Hospital, SE-75185 Uppsala, Sweden; and Department of Tissue Typing Ju.P. ; , FRC Blood Transfusion Service, FIN-00310 Helsinki, Finland.

2. Select appropriate areas of data collection to develop a nursing health assessment for clients experiencing common health problems related to vascular and hematologic functioning. 3. Describe following diagnostic studies and therapeutic regimens. Biochemistry and Biophysics, Texas A&M University, 3 ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, 4 ; Department of Microbiology and Immunology and Howard Hughes Medical Institute, Albert Einstein College of Medicine The global significance of developing novel anti-malarials cannot be understated. We have undertaken a program focused on optimizing the activity of inhibitors of P. falciparum enoyl acyl carrier protein reductase PfENR ; . The B-ring of triclosan 1 ; was modified at the 2' and 4'positions. Analysis of the X-ray crystal structure of 1 bound to the PfENR: co-factor complex suggested derivatization of the 4'-position with hydrogen-bonding groups would facilitate interaction with additional active site residues. A methylamino group off the 2'-position would allow for favorable interactions with the co-factor in addition to the enzyme. The conversion of R1 to groups with hydrogen bond donors and or acceptors afforded less hydrophobic compounds that did not improve significantly upon the potency of 1. Alkylated methylamino derivatives at R2 achieved EC50 values 100 ng mL, affording a 20-fold gain in potency against the parasite. These findings may provide the foundation for the further optimization of triclosan-based therapeutics.

This is where the booster medications come into play and ventolin. 2Ultraviolet Radiation Ultraviolet UV ; radiation 100 to 400 nm ; has had a long and distinguished use in clinical medicine. Several excellent textbooks are available. My lack of motivation existed before the medication treatment. According to a recent report released in the new england journal of medicine of 16, 000 adults surveyed over the age of 24, nearly 30 percent had blood pressure of at least 140 90 and more than one-third of them were unaware of their condition. A 75-year-old woman presented to the A&E department with a fracture of the mid-shaft of her right humerus, which she stated occurred as she was pulling the curtains shut. Past medical history was unremarkable. A DEXA scan performed two years earlier showed normal bone density. On systems review, she complained of lower back pain over the previous six months. Laboratory investigations revealed a normocytic, normochromic anaemia, haemoglobin 9.9 and mild renal impairment, creatinine 136. She re-presented 10 days later with general deterioration, confusion, altered level of consciousness, new faecal incontinence, abdominal tenderness and generalised muscle twitching.

Patrick J. Stiff1, William I. Bensinger2, Christos Emmanouilides3, Z. John Lu4, Alessandra Cesano4, Ricardo Spielberger5 1 Loyola University, Maywood, Illinois; 2Fred Hutchinson Cancer Research Center, Seattle, Washington; 3UCLA David Geffen School of Medicine, Los Angeles, California; 4Amgen, Inc., Thousand Oaks, California; 5City of Hope National Medical Center, Duarte, California Background: Oral mucositis OM ; is a frequent complication of CRT and often is rated as the most debilitating treatment-related side effect. In a pivotal phase 3 clinical trial of palifermin conducted in the HSCT setting, patients placebo 106, palifermin 106 ; were asked to assess their OM severity and functional limitations swallowing, eating, drinking, talking, sleeping ; through a selfreported daily questionnaire Oral Mucositis Daily Questionnaire [OMDQ] ; while physicians used the World Health Organization WHO ; clinical scale for measuring OM severity WHO-OM ; . The feasibility and validity of the OMDQ were evaluated and are reported here. METHODS: OMDQ feasibility was measured by daily compliance rate. Pearson correlation coefficients were computed to measure test-retest reliability, internal consistency reliability, and discrimination validity. RESULTS: The mean daily compliance rate for OMDQ completion over the entire study period was at least 84% in both treatment groups. The Pearson correlation coefficients ranged from 0.60.9, 0.50.8; and 0.30.6 for testretest reliability, internal consistency reliability, and discriminative WHO and OMDQ Scores. `ARROWgird BIue" is a io, nt development of Ddtex Medical Services, Inc., and Arrow International, Inc., using technology developed by Dr. Shonta Modals and colleagues, in the Department of Surgery, Columbia Universi'. U.S. Potent Numbers 4, 612 337; apply. Other U.S. and oreign patents pending. Maid, DG; Wheeler, Si; Stolz, SM; Menmel, IA: Ciinical trial of a novel antiseptic-coated central venous catheter. Abstract of paper presented at 31st ICUC Clinical Infections, October 1, 1991. `DaIsIberg, P1; Yutuc, WR; Newcomer, K1 $ubdavion hemodioly. ssucatheter infections, American Journal of Kidney Diseases, Vol. VU, No.5 Moyl, 1986: pp 421 .427.

Antihypertensive Medications Antihypertensive medications that are associated with fluid reduction diuretics and angiotensinconverting enzyme inhibitors [ACEIs] ; are associated with better cardiovascular outcomes than antihypertensive medications that promote fluid retention calcium channel blockers [CCBs] and -adrenergic receptor blockers [ -blockers] ; .35 Thiazide diuretics are more effective than ACEIs, CCBs, and -blockers at preventing heart failure, and thiazide diuretics are more effective than ACEs and -blockers at preventing strokes.36 40 When compared with -adrenergic receptor blockers and ACEIs, CCBs are less effective at reducing myocardial infarctions and heart failure.36, 37 Non-selective NSAIDs Non-selective NSAIDs cause fluid retention, raise blood pressure, 41, 42 are associated with the development of heart failure, 43 45 and are associated with an increased likelihood of having an ischemic stroke.46 A number of studies have failed to identify.
The records appearing in this Gazette will be added to DOLPHIN, the database Of all pharmaceutical inventions in the next week. Based on the INPADOC database produced by the European Patent Office, it covers all national and international patents with relevance to pharmaceutical research and development published from 1968 onwards and selected patents from earlier years. DOLPHIN contains information on bibliographic data, contents, associated products, legal status, licensees and context of patents, which is presented in a format to convey all aspects of a patent at a glance.
Some recommendations are listed in table 1.
X Voltaren Chapter 15 Respiratory Medications 15.1.1 Beta-2 Adrenergic Drugs albuterol QL X albuterol ER tabs X Accuneb QL X Alupent Inhaler QL X Foradil QL X Maxair-Autohaler QL X albuterol, ProAir HFA ProAir HFA QL, ST X Proventil HFA QL X albuterol, ProAir HFA Serevent Diskus QL X Ventolin HFA QL, ST X albuterol, ProAir HFA Volmax X Xopenex QL X albuterol Xopenex HFA QL, ST X albuterol, ProAir HFA 15.1.2 Methylxanthine Drugs theophylline ER X Theo-Dur X Uni-Dur X Uniphyl X 15.1.3 Other Drugs for Asthma acetylcysteine X cromolyn sodium X ipratropium QL X Advair Diskus QL X Aerobid, Aerobid-M QL X Flovent, Pulmicort Asmanex Twisthaler QL, ST X Flovent, Pulmicort Atrovent Inhaler QL X Atrovent HFA QL X Azmacort QL, ST X Flovent, Pulmicort Combivent QL X Duoneb QL X Flovent Diskus QL X betaxolol QL X Flovent HFA QL X carteolol HCl QL X Intal QL X levobunolol HCl QL X Mucomyst X metipranolol QL X Pulmicort QL X pilocarpine HCl QL X Qvar QL, ST X Flovent, Pulmicort timolol maleate, timolol QL X Spiriva QL X maleate XE Symbicort QL X Advair Alphagan-P QL X Tilade QL X Azopt X Twinject QL X . Betimol X betaxolol, timolol 15.1.4 Leukotriene Modifiers Betoptic S QL X Accolate QL, ST X Singulair also ST ; Cosopt X Azopt, timolol Singulair QL, ST X Epinal QL X Zyflo QL, ST X Singulair also ST ; Iopidine QL X brimonidine, Alphagan-P 15.2.1 Antihistamines Istalol X cyproheptadine X Lumigan QL X fexofenadine QL X Travatan, Travatan-Z QL X hydroxyzine X Trusopt QL X Azopt promethazine HCl X Xalatan QL X Allegra Suspension X OTC loratadine, OTC PA Prior Authorization Required QL Quantity Limits if exceeded, prior auth. required ; ST Step Therapy if criteria not met, prior auth. required ; E Drugs Exempt from Generic Substitution G Generic Drug Substitution Applies SP Specialty Pharmacy 16.
Theo-dur sprinkle produced mean cmax and cmin theophylline serum levels of 1 4 ± 6 and 9 ± 8 mcg ml as compared with a cmax and cmin of 1 5 ± 8 and 5 ± 7 mcg ml for theo-dur tablets.