AstraZeneca has entered into a research alliance with the University of Dundee, the Medical Research Council and five other major pharmaceutical companies including GlaxoSmithKline, Merck and Pfizer. The Alliance, recently renewed, provides the University's Division of Signal Transduction Therapy DSTT ; at the MRC Protein Phosphorylation Unit, with funding of 15m over five years. This supports world class research into two classes of enzymes which are now important drug targets in the industry. Broadening understanding of how these enzymes work is helping to advance the development of drugs to treat many diseases, including cancer, diabetes and rheumatoid arthritis.
A gel of an injection. A physician ordered an ultrasound for a patient in isolation. Attempting to avoid contamination of an entire tube of ultrasound gel, a technician withdrew some gel into a parenteral syringe and brought the syringe into the room. The unused portion in the unlabeled syringe was brought out of the room and left on a medication cart just outside the patient's door. Later, during a mock inspection, the unlabeled syringe, containing about 8 mL of the blue-tinted ultrasound gel, was found on top the cart. Fortunately, the unlabeled syringe did not result in an error, but it does illustrate several important points. Unlabeled syringes containing injectable, topical, or oral products should be discarded. Topical preparations should never be prepared in injectable, or even oral, syringes. A properly labeled topical syringe was really the only safe option or, in this case, a disposable, labeled cup. continued on next page.
The Division of Reproductive Medicine and Infertility is pleased to offer quarterly educational lectures to registered nurses in the area. Physicians and midwives are welcome to attend, as well. Our doctors will cover a variety of topics related to infertility diagnosis, workup and treatment, that will be of interest to registered nurses. FREE CONTACT HOURS, approved by Rhode Island State Nurses Association, will be awarded for participation. The next scheduled talk will be "An Overview of IVF", by Dr. Jeffrey Roberts, on Tuesday, January 31st, 2006, at 5: 30 p.m., at our facility at One Blackstone Place, Providence, RI. For nursing questions, please email Diane Sharkey, RN, at dsharkey wihri . For more information about the seminars, please contact Lara Laskowski, IVF outreach coordinator, at 401 ; 274-1122, ext. 1583, or email her at llaskowski wihri.
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We have survived the past year, and the hepc.bull continues to be published monthly and sent to about 700 people. Our website receives an average of 50, 000 hits a month. Peppermint Patti's FAQ and one of our pamphlets were translated into Spanish. Our pamphlet series is still growing, albeit slowly. We have taken steps to reach out to the aboriginal community. We have been granted 2 practicum nursing students to help with our efforts toward public education, and hope they can help us with an awareness campaign, for which we have developed a power point program. We took part in the Volunteer Fair at Hillside Mall, and made a display board for that. We have replaced the Ladies' and Men's groups with quarterly general meetings. We took part in the organization of the May 1st Hepatitis Awareness Day activities at the Legislature. 2002 has seen the important advent of the BCHepC Circle, and its two conferences, in Nanaimo and in Vancouver, for which HepCBC is at least partially responsible. We are the proud Agency of Record for the Circle, which represents most of the Hep C groups in BC. We still belong to Volunteer Victoria, who sent us Karolyn Sweeting. Did I say we miss her? Our Info Line has taken care of numerous requests, through which we meet the needs of the community by mailing out copies of medical articles to Hep C patients so that they may learn more about the disease, or show their doctors, to help educate them. We have partnered with CLF in presenting their Living with Liver Disease program. We have approximately 97 paid-up, registered members, and 10 associate members, and have had about 45 volunteers, not all of whom are members. About 10 of them are regularly active. We have 158 up-to-date paid subscribers to the hepc.bull, and many more who have asked to receive the bulletin free of charge, since they don't have enough money to pay for a subscription. We have 110 email subscribers, as well. Many others read the bulletin on our website, or receive copies of it from their local support group. As I said, there have been an average of 50, 000 hits to the website and no doubt many of these visitors are checking the hepc.bull or other info at the website. Thanks to the pegylated interferon treatments, more and more people are responding to treatment, but there are still many non-responders out there, and the vast majority who do not qualify for treatment, or cannot tolerate treatment or choose to not be treated. Schering's product is now approved, but Roche's Pegasys is not yet sold in Canada, although it has been approved in the US. Many people have not responded to Schering's products and may have a better chance with another product. For those not eligible for clinical trials, treatment is extremely expensive, running thousands of dollars a month. We must advocate for the approval of other treatments. Our Board desperately needs more members, especially some with fundraising experience and community connections. David Mazoff, our exexecutive director, as I said, has stepped down, and is only minimally involved. We have had a couple hepc.bull.
TABLE 7 Bone mass and bone metabolism on entry and percentage change from entry at 3 and 6 months by treatment group Study entry absolute values ; ICS BUA VOS Urinary pyridinoline: creatine 53.0 4.7 ; n 13 ; 1702 14.5 ; n 13 ; 270.6 16.3 ; n 39 ; 2-only 55.5 5.0 ; n 15 ; 1672 9.0 ; n 15 ; 254.8 22.3 ; n 33 ; 73.3 6.1 ; n 33 ; 3 months % change from entry ; ICS 2.1 6.5 ; n 11 ; 0.004 0.7 ; n 11 ; 4.1 10.3 ; n 27 ; 1.2 10.5 ; n 27 ; 2-only 14.8 11.2 ; n 10 ; 0.39 0.4 ; n 10 ; 13.2 6.1 ; n 34 ; 14.3 6.4 ; n 34 ; 6 months % change from entry ; ICS 10.3 5.7 ; n 11 ; 1.3 1.2 ; n 10 ; 12.4 5.1 ; n 26 ; 9.9 5.2 ; n 26 and lasix.
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LUNENBURG COUNTY PUBLIC SCHOOLS File: TOBACCO-FREE SCHOOL FOR STAFF AND STUDENTS Smoking, chewing or any other use of any tobacco products by staff and students shall be prohibited property as defined in this policy. For purposes of this policy, the following definitions shall apply: 1. "School property" shall mean all property owned, leased, rented or otherwise used by a school including but not limited to the following: a. All interior portions of any building or other structure used for instruction, administration, support services, maintenance or storage. b. Any indoor facility or portion of such facility owned or leased or contracted for and used for the provision of regular or routine health care, day care, or early childhood development Head Start ; services. All vehicles used by the division for transporting students, staff, visitors or other persons. JFCH.
Gayle C. Windham, Lixia Zhang, Robert Gunier, Lisa A. Croen, Judith K. Grether Division of Environmental and Occupational Disease Control, California Department of Health Services, Richmond, CA; Impact Assessment Inc, La Jolla, CA; and Kaiser Permanente Medical Care Program Division of Research, Oakland, CA and lisinopril.
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METHOD This article analyzes interview and survey data that the researcher collected while directing the MindFreedom International Oral History Project from June 1 through September 1, 2001 . The purpose of the MindFreedom Oral History Project was to gather stories of experiences in the mental health system from the psychiatric survivor or ex-patient perspective.
ORGANISATION OF CAUCUSES . 34 THE QUALITY BENCHMARK OF THE SOCIAL SUMMIT . 35 ESTABLISHING MECHANISMS FOR FOLLOW-UP . 37 The original idea . 37 Public announcement . 38 THE FOUNDATION OF SOCIAL WATCH . From Copenhagen to Beijing to Soesterberg to Montevideo to Cyberspace and mesterolone.
Oncologists should consider referring all patients already receiving IV bisphosphonates to a dentist or oral and maxillofacial surgeon for an examination and a surveillance schedule. The dental team should carefully evaluate the oral cavity for exposed bone in the areas most commonly affected, such as the posterior lingual area of the mandible, and for radiographic evidence of osteolysis, osteosclerosis, widened periodontal membrane spaces, and furcation involvements. A dental cleaning and fluoride carriers should be considered, and tooth removal should be avoided if at all possible. If the tooth is nonrestorable because of caries, root canal treatment and amputation of the crown is a better option than removing the tooth. Similarly, teeth that demonstrate 1 or 2 mobility should be splinted rather than removed. If the mobility is 3 or more or is associated with a periodontal abscess, there is a strong possibility that osteonecrosis is already present and the abscess and or granulation tissue is merely covering exposed bone. In these situations, removing the tooth and providing antibiotic treatment, as described in the previous section, is the only recourse. Elective surgery within the jaws, such as removal of third molar teeth or tori, periodontal surgery, or placement of dental implants, is strongly discouraged at this time. Denture wearing is acceptable, but the prosthesis should be examined for areas of excessive pressure or friction and given a soft reline if needed.
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New drug for which the application is submitted; and B ; if with respect to the drug for which investigations described in paragraph 1 ; A ; were conducted information was filed und er paragra ph 1 ; o subsection c ; o f this section for a method of use paten t which d oes not claim a use for which the applicant is seeking approval under this subsection, a stateme nt that the m ethod of use p atent does not claim such a use. 3 ; A ; An applicant who makes a certification described in paragraph 2 ; A ; iv ; shall include in the app lication a stateme nt that the applicant will give the notice req uired by subparagraph B ; to i ; each owner of the patent which is the subject of the certification or the representative of such owner designated to receive such notice, and ii ; the holder of the approved application under subsection b ; of this section for the drug which is claimed by the patent or a use of which is claimed by the patent or the representative of suc h hold er designated to rece ive such notice. B ; The notice referred to in subparagraph A ; shall state that an application has been submitted under this subse ction for the drug with respect to which the certification is made to ob tain approval to engage in the commercial manufacture, use, or sale of the drug before the expiration of the patent referred to in the certification. Such notice shall include a detailed statement of the factual and legal basis of the applicant's opinion that the patent is not valid or will not be infringed. C ; If an application is amended to include a certification described in paragraph 2 ; A ; iv ; , the notice required b y subp aragraph B ; shall be given when the amended application is subm itted. 4 ; A ; The Secretary shall issue guidance for the individuals who review applications submitted under paragraph 1 ; or under section 262 of title 42, which shall relate to promptness in conducting the review, technical excellence, lack of bias and conflict of interest, and knowledge of regulatory and scientific standard s, and w hich sha ll apply equally to all individ uals who review such app lications. B ; The Secretary shall meet with a sponsor of an investigation or an applicant for approval for a drug under this subsection or section 262 of title 42 if the sponsor o r app licant makes a reasonable written request for a meeting for the purpose of reaching agreement on the design and size of clinical trials intended to form the primary basis of an effectiveness claim. The sponsor or applicant shall provide information necessary for discussion and agreement on the design and size of the clinical trials. Minutes of any such meeting shall be prepared by the Secretary and made availab le to the sp onso r or ap plicant upon request. C ; Any agreement regarding the parameters of the design and size of clinical trials of a new drug under this paragraph that is reached between the Secretary and a sponsor or applicant shall be reduced to writing and made part of the administrative record by the Secretary. Such agreement shall not be changed after the testing b egins, except i ; ii ; with the written agreement of the sponsor or applicant; or pursuant to a decision, made in accordance with subparagraph D ; by the director of the reviewing division, that a substantial scientific issue essential to determining the safety or effectiven ess of the drug has be en identified after the testing has begun. D ; A de cision under subp aragraph C ; ii ; b the director shall be in writing and the Secretary shall provide to the sponsor or applicant an opportunity for a meeting at which the director and the sponsor or applicant will be present and at which the director will document the scientific issue.
PURPOSE To ensure accurate clinical documentation in all clinical information systems paper or electronic ; POLICY In order to ensure accurate clinical documentation in all clinical information systems paper or electronic ; , any revisions to dictated clinical documentation must be captured in the electronic systems. Whenever possible, revisions are made in the electronic system in which the document originated i.e., Dictaphone Text, Co-Path, Chartscript, IDX, etc ; . If the original document is no longer retained in that system, then a new addendum document must be created. If the originating system does not provide a mechanism for revisions, the revisions will be made in the receiving system s ; . A copy of the revised documentation must be interfaced to or scanned by all receiving electronic systems and or filed in the paper-based medical record per established protocols ; . The original, unaltered document must remain as part of the electronic patient record, and the patient record must permit access to the original document on demand. Revisions are made in the format of either edits within the original document or addenda to the original document, and must change the content of the documentation. Revisions of documents for non-substantive changes e.g. typos ; is costly, and considered unnecessary rework. PROCEDURE S ; Dictating Edits or Addenda in the Regions Dictaphone Text System: Edits are used to correct unsigned documents 30 days from date of service or discharge; addenda are used to correct signed documents and documents 30 days from date of service or discharge. Dial dictation system 254-5454 ; Enter 4-digit dictator ID, 2-digit worktype, and 13-digit encounter number, as prompted. Begin dictating as follows: "The following dictation is an edit or addendum ; to document ID # found at bottom of transcribed report ; , patient name and patient MRN" Dictating Corrections to Administrative Errors: Dictate an addendum to correct an erroneously and nexium.
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So students at King's are withholding payment of their College Bills perhaps not surprising given that average rents at King's have gone up more than 29% since 1999, almost in line with the original Bursars' report that sparked rent strikes four years ago. But in last year's room ballot students, with few exceptions, picked the most desirable albeit most expensive rooms first. So, given that the College loses significant amounts of money on providing accommodation, that rents are still well below market rates, and that most students seem to be able to afford them, how can such increases not be justified? The answer lies in what is still the `few exceptions'. Government statistics and league tables show that top universities and Cambridge in particular are missing out on able applicants from non-traditional and less-affluent backgrounds. As rents go up simple affordability will begin to segregate those who can afford any room and those who are financially barred from this choice. Such `two-tiering' is an active deterrent to potential applicants. The University prospectus has finally admitted that the minimum amount an undergraduate needs to live on is 4, 900 per year, 1, 000 more than the maximum student loan, leaving a black hole in the pockets of students who just miss out on the full loan. Conventional `hardship funds' are not the answer. It is unacceptable for students to rely on these when the money runs out, simply to pay their College Bills. Just as the conditions under which students are eligible for Newton Bursaries are now systematic and clearly publicised, colleges must provide simple, precise support schemes that will determine costs up-front. Colleges must stop trying to build over-ambitious new accommodation designed to make a statement and meet conference demands rather than fit basic student needs. King's, for example, has spent over 90, 000 per room on its latest building projects, nearly four times what HEFCE recommend, and the loss of this investment capital is a major cause of the College's current deficit. "It is reasonable for government to ask why 75 per cent of the intake to universities comes from middle-class backgrounds, as it did 40 years ago, " wrote Charles Clarke last November. No doubt a large element of this is due to school and social environments where the aspiration of higher education is inequitably imparted. But Clarke's observation will continue to hold unless a genuine consideration of affordability to all students informs every rent, catering and facilities decision made across British universities.
Observations in the field There are a large number of psychotropic medications which are likely to be misused. The brand names frequently referred to by the TREND Tendances rcentes et nouvelles drogues: Recent trends and new drugs ; structure are Tranxene dipotassic clorazepate ; , Stilnox zolpidem ; , Imovane zopiclone ; , Rivotril clonazepam ; , Artane trihexyphenidyle ; , Rohypnol flunitrazepam ; and Valium diazepam ; . They are mostly drugs of the benzodiazepine family. Three medications for which the recording structure allowed the collection of pertinent information are covered here: two benzodiazepines Rohypnol and Valium ; and Artane, an anti-Parkinson's drug.
The component of trend attributable to emerging technologies proves to be a continuing, yet highly variable, driver of medical expense trend. Professional and facility trend impact varies from year to year.
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|Animals would be needed to establish the exact relationship between tryptophan pyr rolase adaptation and plasma tryptophan concentration as described by Given and Knox 9 ; , similar plasma tryptophan con centrations gave different results in rats and ruminants. If tryptophan has a similar activating and stabilizing effect on trypto phan pyrrolase in ruminants, it would also be expected to increase the enzyme activity in these species. Since little or no adapta tion of enzyme was evident in ruminants.
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The HIV AIDS module of the 2004 Kenya Service Provision Assessment 2004 KSPA ; was designed to provide information on the capacities of sampled health facilities to provide HIV AIDS services. The relevant indicators were initially developed by a technical working group comprising World Health Organization WHO ; , UNAIDS, United States Agency for International Development USAID ; and invited Non Governmental Organizations NGOs ; . We wish to acknowledge contributions from the staff of National Coordinating Agency for Population and Development, Ministry of Health, University of Nairobi, Central Bureau of Statistics and all who helped in the development of instruments used in the collection of information, facilitated data collection, analysis and the writing of this report. The interviewers that collected this information comprised of nurses and social scientists that were selected by Provincial Medical Officers. We wish to thank them all for their contribution to making this report a success. We also appreciate the financial and technical support given by USAID, DFID, UNICEF and ORC Macro USAID sub-contract ; . In particular, the contribution of the PEPFAR to this activity was very important and their contributions were well received.
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The women in the studies were already taking oral contraceptives and thus would "automatically" be able to tolerate the medication; they were not compared with a control group of women who were not taking oral contraceptives. The supporters of menstrual suppression argue that ovulation itself can inflame the lining of the ovary and might be linked to ovarian cancer. The debate, no doubt, will rage on. Because Seasonale users can expect to have fewer periods, the label also advises women to consider the possibility that they might be pregnant if they miss any scheduled periods. Sources: FDA, fda.gov; Barr Laboratories, September 8, 2003; bar rlabs ; seasonale ; Pittsburgh Post-Gazette, June 24, 2003.
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