The above amounts include non-pension post-employment benefit schemes, principally medical plans, with an actuarial present value of obligations of 690 million Swiss francs 1999: 703 million Swiss francs ; and plan assets of 649 million Swiss francs 1999: 576 million Swiss francs ; . The related net liability recognised is 147 million Swiss francs 1999: 190 million Swiss francs ; . Actuarial gains of 106 million Swiss francs 1999: 63 million Swiss francs ; were unrecognised. Amounts recognised in the balance sheet for post-employment defined benefit plans are predominantly non-current and are reported as long-term assets and non-current liabilities.
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Provision in Article 27. This would include the existing procedure, whereby Council Decisions lay down the procedures by unanimity. Article 28 4 bis ; : This provision has been inserted in paragraph 4 bis because CFSP has its own procedures for adopting its own distinctive instruments. And different legislative procedures will be required for ex-third pillar.
Does uluerution occur only in a lesion with a dense, hard, fibrous or hyaline cap overlying the soft atheromatous mass? 2 ; Why do some ulcers, but by no means all, lead to thrombosis? Experimental work on this aspect of atherosclerosis is scanty. Besides our work, 1"11 there are the reports of Wakerlinr'on the abdominal aortae of dogs, and of Constantinides0 on the aortae and coronary arteries of rabbits. In our experiments, ulceration occurred predominantly in the abdominal aorta at the site of the usual fibrotic spontaneous lesion which, in the presence of an atherogenic diet, becomes a site of predilection for lipid deposition, as described in our previous communications.10'11 Therefore, in our experiments on chicks, the same morphological pattern leading to ulceration is evident as in man and rabbit. In chicks, the ulceration is almost predictably triggered by estrogen administration superimposed on a lesion with a particularly soft core induced by the combination of a low-protein, high-fat, high-cholesterol diet. How estrogens produce these changes is a matter of speculation at present. From the sequence of events in regression of corouary atherosclerosis, it seems probable that the disappearance of the lipid in the lesions is associated with absorption and transport to the and imovane.
OWNERSHIP OF MAIL-ORDER PHARMACIES that plan sponsors were concerned about non-price dimensions of service, such as benefit design, the extent of the retail network, and the quality of mail-order service. The Commission collected data on the amounts that PBMs pay to the plan sponsor to help defray the costs of switching to the PBM at the start of a new contract or bonus amounts to obtain or retain the plan sponsor as a customer. 29 The data revealed that large PBMs and retailer-owned PBMs often make these payments, but they usually do not total more than 0, 000 per client. There were exceptions. In 2002 and 2003, some PBMs made payments to plan sponsors that ranged between .5 and million per client. The Commission staff's review of PBM contracts with plan sponsors suggested that member satisfaction, dispensing accuracy rates, turn-around time at mail pharmacies, wait time for customer service calls, distance to a network retail pharmacy, and timeliness of management reports are also key factors in any contract. 30 Most PBM-plan sponsor contracts included performance guarantees e.g., prescription fill time, call center response time, and generic substitution rates ; that required the PBM to make specified dollar payments to the plan sponsor if the PBM failed to meet the guarantees. 31 PBMs often work with plan sponsors to create plan designs with copayments, coinsurance, or deductibles that provide members with incentives to comply with a plan s formulary. 32 Those incentives range from differential copayments to complete denial of coverage for out-of-network or off-formulary purchases. Plan sponsors and PBMs also may negotiate over incentives for enrollees to use mail-order pharmacies for maintenance medications. 33 The PBM's contract with a plan sponsor covers the amount that the plan sponsor will pay to the PBM for each prescription dispensed at a network retail pharmacy. The PBM's charge to the plan sponsor per prescription is similar in form to the retail pharmacy contract. For brand drugs, it is a discount off AWP plus a dispensing fee and an administrative charge per script, e.g., "AWP minus 10% plus .50 plus ##TEXT##.10." For generic drugs, the charge is similarly calculated, but the discount is usually off of the price specified on the PBM's MAC list. 34 Some PBMs earn revenues and profits through the "spread" between the amount charged to a plan sponsor and the amount paid for the drug product, including a dispensing fee if any, to the retail or mail-order.
The statins are well tolerated by most persons. Elevated hepatic transaminases generally occur in 0.5% to 2.0% of cases and are dose-dependent 11, 12 ; . Whether transaminase elevation with statin therapy constitutes true hepatotoxicity has not been determined. Progression to liver failure specifically due to statins is exceedingly rare if it ever occurs 13 ; . Reversal of transaminase elevation is frequently noted with a reduction in dose, and elevations do not often recur with either re-challenge or selection of another statin 14, 15 ; . Cholestasis and active liver disease are listed as contraindications to statin use; however, no specific evidence exists showing exacerbation of liver disease by statins. Furthermore, statins have not been shown to worsen the outcome in persons with chronic transaminase elevations due to hepatitis B or C, and treatment of hyperlipidemia may actually improve transaminase elevations in individuals with fatty liver 16 ; . An observational study 16a ; has suggested a rare association of statin use with polyneuropathy. This has not been found in the large blinded randomized controlled trials. The ability of statins to produce myopathy under some circumstances is well established. A common complaint is non-specific muscle aches or joint pains that are generally not associated with significant increases in creatine kinase. In placebo-controlled trials, the incidence of these complaints generally reported as about 5% ; is similar between placebo and active drug therapy, suggesting they may not be drug-related 1217 ; . Nonetheless, in some patients, the temporal association with statin therapy is strong enough to implicate these drugs as a cause of these complaints. Other patients can have mild-to-moderate elevations of creatine kinase without muscle complaints. Again, elevations may be non-specific, but a statin effect often cannot be ruled out. It is rare that patients treated with a statin exhibit severe myositis characterized by muscle aches, soreness or weakness and associated with elevated creatine kinase levels, generally greater than 10 times the ULN. In this setting, failure to discontinue drug therapy can lead to rhabdomyolysis, myoglobinuria, and acute renal necrosis 18 ; . Myositis is most likely to occur in persons who have complex medical problems and or who are taking multiple medications. It may rarely occur with statin monotherapy, but it occurs more frequently when statins are used in combination with a variety of medications, including cyclosporine, fibrates, macrolide antibiotics, certain antifungal drugs, and niacin 19 21 ; . Some of the drug to drug interactions involve specific interactions with the cytochrome P-450 drug-metabolizing system, especially those involving the 3A4 isozyme 22, 23 ; . The combination of statins with a fibrate is attractive for persons who have both high serum cholesterol and high triglycerides or for those who continue to have elevated triglycerides after reaching their LDLcholesterol target on statin therapy. However, there may be a concern about an increased danger of developing myop and lasix.
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Let us begin with the consideration of biovalue and the creation of wealth. Contemporary biomedicine, by rendering the depths of the body visible, intelligible, calculable and capable of intervention at a molecular level, makes it amenable to the production of economic value. In many ways, what is being accomplished through the life sciences is a kind of `flattening' of the vital processes of the body. This not only enables these `surfaces' to become equivalent with one another at the most basic biological level, but also allows them to be enfolded within processes of capital or social accumulation. They contain the potential to transform the vitality of each and all of us into a standing reserve for the creation of biovalue. One area where this is occurring draws on the health technologies of social citizenship and redeploys them in the service of biovalue. Two examples of this logic can be found in Sweden and Iceland and levitra.
12 ; PATENT APPLICATION PUBLICATION 19 ; INDIA 21 ; APPLICATION No: 466 CHE 2004A 22 ; Date of filing of Application: 18 05 04 Publication Date: 21 04 2006 ; Title of the invention: 71 ; Name of Applicant AUTO-POWERED VEHICLE AND A.RAJENDRA BABU GENERATOR 51 ; International classification: B 62 D Address of Applicant: A.RAJENDRA BABU 31 ; Priority Document No. S O M.ARUMUGAM, NO77A, P.T.RAJAN, 32 ; Priority Date: SALAI, K.K.NAGAR, CHENNAI-600 078, TAMIL NADU, INDIA 33 ; Name of priority country: 72 ; Name of the Inventor s ; : A.RAJENDRA BABU 87 ; WIPO No. : 61 ; Patent of addition to Application No. : Filed on: 62 ; Divisional to Applcation No.: Filed on: 57 ; Abstract The invention is devised and designated as auto-powered circuit system applied in electric Vehicle and generator, connotes that in the system, the electrical energy required to run the Vehicle or generator is generated by the system itself, and the mechanism included four main drive 12 volt batteries connected serially to DC motor through the Silicon Diode. With the DC supply, DC motor operates the mechanism like running the vehicle simultaneously producing retractable Supply, returned to and recharging the Battery, that in turn lined with the circuit of DC motor and Dyanamo, recharges the Four main drive Batteries. Thus, by this invented mechanism, the charge in the Main batteries is always maintained. This Invention is made practically possible by crucial role of Silicon diode and Dynamos and in this invention in Vehicle, a back-up battery also provided. This invention removes the limitation of charging the electric vehicle externally and discharging and charging of supply is done Simultaneously through the same electric winding coil of DC motor. Moreover, this invented basic circuit system is workable in any electric devices.
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The site at NCBI see Table 2 ; has attempted to collate all the available information as well as that for other Plasmodium species and the related apicomplexan parasite Toxoplasma gondii ; . A recent development, funded by the Burroughs Wellcome Fund, has established a full database : PlasmoDB ; . In its current form, PlasmoDB provides: views of finished and annotated sequence in both web-based and CD format; a relational database that should facilitate entry and analysis of expression data; a BLASTable database containing the most recent genomic sequence information finished and unfinished text-queriable results from a complete BLAST search of all P. falciparum data against GenBank + EMBL; and various other data-mining tools. In addition to the obvious interest of PlasmoDB to the malaria research community, WHO TDR has made a commitment to provide on-line 'help-desk' support for PlasmoDB and other parasite databases ; through training of scientists bioinformaticians from developing countries. 3.2. Microarrays Microarrays are high-density arrays of DNA targets on glass or filter supports. These have been used in several studies, most notably for S.cerevisiae. There are essentially two formats for the DNA targets, namely DNA fragments usually generated by PCR ; or oligonucleotides. PCR-derived targets for P. falciparum have been produced from genome sequence data D. Carrucci, pers. comm. ; or by the amplification of sequences from a mung bean nuclease library. In the mung bean nuclease library study 34, arrays were made from a random library and screened with mRNA from asexual trophozoite ; and sexual gametocyte ; stages. The RNAs were labelled with different fluorochromes and allowed to hybridise to the arrays. Genes transcribed during asexual stages were labelled green, sexual stages labelled red and yellow signal green + red ; for genes that were active during both stages. From this single experiment the authors identified several developmentally regulated genes, including some which had been previously identified, confirming the efficacy of this approach. The potential for these types of experiments is great but will require careful data handling and analysis. Hayward et al34 identified their candidate genes by sequencing the inserts after hybridisation but once the genome has been completely sequenced the address of each ORF open reading frame ; will be stored as part of the array information. An array covering all of the genes in the P. falciparum genome in duplicate would have approximately 12, 000-14, 000 spots, therefore every experiment would generate at least 14, 000 quantitative data points per probe, in addition to the array baseline information. It is not hard to see that without a highly efficient database, the efficiency and accuracy of any analysis would be greatly reduced, particularly as transcriptional changes are likely to be defined by `clusters' of genes35 which makes the contribution of individual genes difficult to interpret. The database must be accessible by the research community in order to take full advantage of the results and, as seen for C. elegans : wormbase ; , a centralised database is essential. Transcriptional analysis for P. falciparum is also being attempted by Serial Analysis of Gene Expression SAGE; 36 D. Wirth, pers. comm. ; . This technique uses PCR amplification of mRNA to derive short sequence tags that are.
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Results and Discussion In the present study, immunostaining clearly demonstrated prominent expression of AT1R in the metastatic lung tumors of mice Fig. 1A ; . We also observed that 9 of 10 patients showed AT1R expression in lung metastases Fig. 1B; Table 1 ; , which was consistent with our results in mice. The AT1R is expressed in various normal organs, including the blood vessels, brain, kidney, lung, liver, adrenal gland, and pituitary gland 14 ; . In situ hybridization of angiotensin receptor mRNA and ligand-binding assays have shown that the main AII receptor subtype in the pulmonary vessels is type 1 15 ; . The present study showed that not only endothelial cells, but also tumor cells.
Exposure to RAD-243, and after drug washout. The average current in the lowest row show a clear drug-induced reduction of the peak current, and progressive decline in current amplitude for the duration of the 200-ms pulse. Open times during control and drug exposure were fit with single exponentials. The mean open times were 3.3 3.6, 1.9 and 3.8 3.5 during control, exposure to RAD-243, and and motrin.
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3.38 ; . Such a criticality expresses the number of hours lost during the mission generated by the failure mode. The criticality figures are not significant for the Damage Risk at the top level, but only at the bottom ones, a cause of the construction of the hazard rates. The BLMS components are ordered in table 4.7 with decreasing criticality. The VME fan tray and the VME power supply are between the most critical, thank to their high failure rates. The possibility that the VME crate could operate with a reduced cooling and the 2oo3 redundancy is not taken into account in the analysis. The components with the highest net criticality are the integrator, the IC and the monostable the High Tension power supplies are redundant ; . The criticality of these components is given by their functions, which could generate a Damage Risk. In the fault tree analysis, it will be shown how the criticality of the amplifier and of the monostable has been reduced with the 10pA test, while the IC becomes more critical due to the Gain test executed only annually. This criticality analysis is limited by not taking into account the quantity of the component in the system. In the BLMS this limitation is reflected by an underestimation of the criticality of the components which have a high probability to generate either a false alarms or a warning. This limited validity of the results is one of the defects of the FMECA. In case of complex system, with redundancies or subsystem failures which do not propagate.
The prescribing physician should avoid prescribing this medication to women who are pregnant, nursing, or who have a high likelihood of becoming pregnant.
ORAL ANTIVIRALS Mr. Smith presented the recommendations for the oral antivirals. HID's recommendation is to continue with the current preferred products including acyclovir, ribavirin Copegus, Rebetol, generic ; , Hepsera, ganciclovir, Valtrex and Valcyte. Two speakers were heard: Richard Prejeen, Famvir, Novartis; Carol Collins, Valtrex, GSK. Mr. Jones made a motion to accept HID's recommendation as presented. Mr. McFerrin offered a second. Discussion followed regarding single day dosing of Famvir for recurrent genital herpes from a pricing standpoint. Mr. Jones and Mr. McFerrin withdrew their motion and second.
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Unidirectional organization of alpha-smooth muscle actin microfilament network is lost in aged human dermal myofibroblasts T Zuliani, C Gondran, S Talbourdet, F Bonte and M Dumas Laboratoires R et D, L.V.M.H. Branche Parfums et Cosmetiques, Saint Jean de Braye, France Skin myofibroblasts MF ; participate in wound healing contraction and dermal neoformation. Their contractile activity is attributed to a well-developed cytoplasmic microfilament network composed of myosin and actin, particularly alpha-smooth muscle actin alpha-SMA ; , expressed throughout the philogenetic tree in cells whose main function is contraction. MF are connected to the extracellular matrix by specialized structures called fibronexi, where actin microfilaments and extracellular fibrils are organized into a close association, mediated by the integrin family of adhesion receptors. alpha-SMA expression was investigated by direct immunostaining on 8 normal dermal fibroblast DF ; strains from abdominal skin of healthy females 24 to 60 year old ; after 10 days treatment with 1 ng ml TGF-beta1, a potent inducer of the MF phenotype. Indirect immunostaining of integrinbeta1 and cell adhesion measurement on coated type I collagen were also performed. Alpha-SMA expression was stimulated by TGF-beta1 in all strains by a factor 2 to 20 ; but no significant differences were observed between young and old strains the latter exhibiting the largest heterogeneity. Interestingly, confocal microscopy showed a multidirectional alpha-SMA microfilament network in older cells, the younger ones showing an unidirectional feature. Adhesion was greater for MF than for DF according to the higher integrin-beta1 expression measured on these cells but no statistical differences were observed between the two age groups. We hypothesize that the impairment of wound strength as a function of age may be due to a dispersion of the contractile forces throughout the multidirectional actin microfilament network of MF, more than a reduced ability of aged cells to express alpha-SMA in response to cytokines or a defect in their adhesion properties.
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C9H8O4. M: 180.16. White, crystalline solid. MP: 138 140C. Slightly soluble in water. Soluble in oxygenated and chlorinated solvents. Production: acetic anhydride + salicylic acid O-acetylation ; Derivatives: benorilate; 4-hydroxycoumarin; phenprocoumone Uses: analgesic antipyretic antiinflammatory antiplatelet drug.