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Attempts are being made to help refugee physicians practise in Britain. The move comes as the National Health Service NHS ; seeks to bolster the MD supply by 2000 GPs and 7500 specialists by 2004. "Given that the NHS is critically short of doctors and it costs [Can0 000] to train one, it seems such a waste not to help qualified professionals, " said Dr. Edwin Borman, chair of the British Medical Association's BMA ; International Committee. The BMA is working to help more than 600 refugee physicians, but Borman thinks there are many more who would like to resume their careers. In Canada, provincial governments and the colleges of physicians and surgeons are responsible for integrating such physicians into the medical system. ; The BMA and the Jewish Council for Racial Equality JCORE ; have published a guide for refugee doctors, which covers topics such as the NHS and requirements for practising in the UK. JCORE Director Edie Friedman says many refugees lack information in these areas and seemed resigned to being unable to practise. She said funding for doctors seeking requalification is "very patchy"; if more was made available it could actually cost far less than training new MDs from scratch. The BMA, which waives membership fee for refugee doctors in financial need, also offers a free package of benefits for asylum-seeking MDs and provides an informal mentoring program. There are no similar programs at the national level in Canada. The BMA's working paper on ways to help refugee physicians bma ; notes that many of them were well advanced in their careers when they fled and they are now having a hard time adjusting to the training needed to meet requirements. Others may have had their training interrupted or their documentation destroyed and have difficulty securing references. As well, they often lack fluency in English. -- Mary Helen Spooner, West Sussex, UK. 7Antidepressants: Severe CNS toxicity associated with hyperpyrexia and death has been reported with the combination of tricyclic or tetracyclic antidepressants, selective serotonin reuptake inhibitors SSRIs ; , or serotonin-norepinephrine reuptake inhibitors SNRIs ; and non-selective MAOIs or selective MAO-B inhibitors. Therefore, the coadministration of antidepressants with rasagiline is contraindicated See CONTRAINDICATIONS ; . Effect of AZILECT on other drugs: No additional in vivo trials have investigated the effect of AZILECT on other drugs metabolized by the cytochrome P450 enzyme system. In vitro, studies showed that rasagiline at a concentration of 1g ml equivalent to a level that is 160 times the average Cmax ~ 5.9-8.5 ng mL in Parkinson's disease patients after 1 mg rasagiline multiple dosing, did not inhibit cytochrome P450 isoenzymes, CYP1A2, CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4 and CYP4A. These results indicate that rasagiline is unlikely to cause any clinically significant interference with substrates of these enzymes. 22 104, 116, Pavot's electroneurodiagnostic study diagnosed lumbar facet syndrome, while Press's lumbar spine examination revealed scoliosis and atherosclerosis. Bentt also noted that Butler's MRI and CT myelogram indicated ``nerve root pathology at both L45 and L5S1.'' Id. 132. And even Hall's RFC assessment lists Butler's primary diagnosis as herniated disk disease. Id. 82. The ALJ may have thought that these diagnosed conditions could not produce the degree of pain Butler claimed to suffer but such a conclusion would be near impossible to understand without some explanation, if for no other reason than that the diagnoses are consistently accompanied by descriptions of incapacitating pain. See, e.g., Id. 132, 14849, 203. The ALJ may have rejected these evaluations by inferring from Yan's and Press's reports that Butler's condition could not produce severe pain; however, he has not articulated this position and, given all of the evidence to the contrary, the record cannot do it for him. D. VOCATIONAL EXPERT'S TESTIMONY Butler asserts that at step five the ALJ improperly relied on the vocational expert's testimony to establish that she is capable of performing ``other work.'' We agree. If the ALJ looks to a vocational expert in assessing a claimant's ability to do other work, the ALJ ``must accurately describe the claimant's physical impairments in any question posed to the expert.'' Simms, 877 F.2d at 1050; see also Williams, 997 F.2d at 1499; Diablo, 627 F.2d at 283. Deficiencies in the ALJ's description of the claimant's condition ``undermine the foundation for the expert's ultimate conclusion that there are alternative jobs'' that the claimant is capable of performing. Simms, 877 F.2d at 1053; see also Williams, 997 F.2d at 1499. We cannot say that the hypothetical question the ALJ posed to the vocational expert accurately reflected Butler's physical limitations. The ALJ asked whether work exists in the economy for someone of ``claimant's age, education, and work background'' who can perform a limited range of seden. REMP is the global leader in the supply of large-scale automated storage and retrieval systems for compound management in the pharmaceutical and biotechnology industries. Compound management is a key foundation of the drug discovery and development process as compound libraries represent one of the most important assets of life science companies. Q45 What screening tests should be used for diabetic eye damage in adults with type I diabetes? Author Title Reference Yr N Research Design Aim Population Larsen, N., Godt, J., Grunkin, M., Lund-Andersen, H., & Larsen, M. 2003, "Automated detection of diabetic retinopathy in a fundus photographic screening population", Investigative Ophthalmology & Visual Science., vol. 44, no. 2, pp. 767-771. N 260 eyes in 137 diabetic patients. Location: The Steno Diabetes Center, Greater Copenhagen area of Denmark. Sites: 1. Diagnostic study. The study evaluated the performance of an automated fundus photographic image-analysis algorithm in high-sensitivity and or high specificity segregation of patients with diabetes with untreated diabetic retinopathy from those without retinopathy. Inclusion criteria per patient were an established history of diabetes mellitus, type 1 or type II and availability of at least one macula-centred colour fundus photograph from at least one eye. Exclusion criteria per eye were previous photocoagulation or surgical treatment of diabetic retinopathy or other vitreoretinal disease and media opacities precluding adequate visualization of the fundus by fundus photography, as evaluated at the routine screening sessions. An automated fundus photographic image-analysis algorithm Retinalyze System; Retinalyze A S, Hrsham, Denmark ; . The reference standard which was a grading of macula-centred slides by an experienced ophthalmologist who classified each eye as having or not having diabetic retinopathy. The photographs were shown in random order of presentation. The reference grader was allowed as much time as needed to review the slides. The grading was made with the aid of magnifiers and a slide projector. Additionally comparisons were made with routine grading by a retina specialist. Sensitivity and specificity to detect retinopathy. No patient characteristics reported. The automated lesion detection correctly identified 90.1% of patients with retinopathy and 81.3% of patients without retinopathy. All patients with false-negative gradings had been reference-graded as having questionable retinopathy or minimal nonproliferative retinopathy with red lesions only. A per-eye analysis demonstrated that the automated lesion detection could be adapted to simulate various visual evaluation strategies. When adapted at high sensitivity, the automated system demonstrated sensitivity at 93.1% and specificity at 71.6%. When adapted at high specificity the automated system demonstrated sensitivity at 76.4% and specificity at 96.6%, closely matching routine visual grading at sensitivity 76.4% and specificity 98.3%. DS.
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INTRODUCTION Proposals to establish Quantitation Limits requirements for USP monographs were originally published in Pharmacopeial Forum in 2004 2 ; . The proposal included a Quantitation Limit Solution at a 0.05% concentration level relative to the amount of drug substance in the Test Preparation for drug substance and a 0.1% level relative to the amount of drug substance in the Test Preparation for the drug product. The proposed requirement was that the signal-to-noise S N ; ratio for the drug substance peak obtained with the Quantitation Limit Solution should not be less than 10. The purpose of the requirement was to ensure that appropriate quantitation limits could be met for calculating impurity levels in the drug substance and drug product Test Preparations. Recently, USP has postponed indefinitely the implementation of the requirements of the text pertaining to quantitation limits in General Chapter Chromatography, System Suitability h621i. This Stimuli article explores the calculation of detection sensitivity and approaches to calculate quantitation limits in current and new monographs. TERMINOLOGY The draft USP proposal for the addition of detection sensitivity requirements relates to those monographs that have chromatographic-related specifications. The logic behind the requirement is to ensure that the procedure provides adequate quantitation capability to accurately quantify organic impurities related compounds ; . The provision for such calculations as part of system suitability ensures that related compounds of interest can be quantified accurately each time the procedure is implemented in a laboratory. The literature is replete with discussions of detection limits, including discussions of limits of quantitation and limits of detection 37 ; . USP had originally proposed the terminology detection sensitivity in consideraMember USP General Chapters Expert Committee Correspondence should be addressed to: Horacio Pappa, Ph.D., Senior Scientist and Latin American Specialist, 12601 Twinbrook Parkway, Rockville, MD, 208521790; e-mail: HP usp and meridia.

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DEPARTMENT OF EDUCATION The Commission for Independent Education hereby gives notice of the issuance of an Order regarding the Petition for Variance for Florida Auctioneer Academy, Inc., License #667. The Notice of Petition for Variance was published in Vol. 30, No. 14, of the April 2, 2004, Florida Administrative Weekly. The Commission considered the instant Petition at a duly-noticed public meeting held on May 21, 2004. The Commission's Order, filed on June 22, 2004, denies the Petition, finding that Petitioner has not established that the purpose of the underlying statute, Section 120.542 2 ; , would be met by granting a variance or waiver from subsection 6E-2.004 6 ; , Florida Administrative Code. The Commission further finds that Petitioner has failed to establish that applying the requirements of the aforementioned Rule to his circumstances would violate principles of fairness or impose substantial hardship. A copy of the Commission's Order may be obtained by contacting: Samuel L. Ferguson, Executive Director, Samuel L. Ferguson, Executive Director, Commission for Independent Education, 2650 Apalachee Parkway, Suite A, Tallahassee, Florida 32301.
The Group 1.2.1 The Company's principal activity is that of a holding company. 1.2.2 The Company currently has the following subsidiary undertakings within the meaning of section 736 of the Act: Interest held directly or indirectly ; by the Company % ; Name Field of activity Evolutec Limited Research and development of pharmaceutical products 100 Vacs of Life plc Dormant 100 Oxford Vacs Limited Dormant 100 Bravacs Limited Dormant 100 Optevol Limited Dormant 100. Center for Health Education Reider Laser Symposium Codman Div. of Johnson & Johnson Denver Shunt System.

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DRUG UPDATE Fulvestrant Faslodex ; injection has recently been granted approval by Health Canada as a treatment of estrogen-receptor positive metastatic breast cancer in postmenopausal women with disease progression following antiestrogen therapy tamoxifen and any aromatase inhibitor ; . Until now, this drug has been available free of charge through the Special Access Programme SAP ; . With the Health Canada approval, fulvestrant is no longer available via SAP. Fulvestrant is not currently a BCCA benefit drug. AstraZeneca, the manufacturer, has set up a Faslodex Named Patient Program for the following patients: 1. Patients currently receiving fulvestrant: Patients will continue to receive free drug provided that their physicians apply to the Faslodex Named Patient Program. 2. New patients starting fulvestrant: For now, new patients who fit the Health Canada approved indication can apply to the Faslodex Named Patient Program to be assessed to receive free drug. Patients should be made aware currently it is unclear of the long term funding for this treatment through this program. Physicians treating patients with fulvestrant will still need to receive BCCA undesignated approval. Patients who do not fit the Health Canada approved indication will be reviewed on a case-by-case basis by the BCCA Breast Tumour Group and Provincial Systemic Therapy Program. The contact number for the Faslodex Named Patient Program is 1-800-565-5877 local 6091. For more information, call the BCCA Undesignated Indication Requests at 604 ; 877-6277 or 1-800 633-3333 local 6277. Fulvestrant clinical trial at BCCA: A new phase III randomized, double blind, multicenter clinical trial comparing the efficacy and tolerability of fulvestrant versus exemestane in postmenopausal women with hormone receptor-positive advanced breast cancer with disease progression after prior non-steroidal aromatase inhibitor therapy is underway at the BC Cancer Agency. This trial is being conducted at the Vancouver Centre only. The principal investigator is Dr. Stephen Chia, the clinical trials nurse is Debbie Jepson. CANCER MANAGEMENT GUIDELINES The Cancer Management Guidelines are available on the BC Cancer Agency website : bccancer.bc CaMgmtGuidelines ; under Health Professionals Info, Cancer Management Guidelines. PROVINCIAL SYSTEMIC THERAPY PROGRAM POLICIES BC Cancer Agency Systemic Therapy Policies are available on the BC Cancer Agency website bccancer.bc ; under Health Professionals Info, Chemotherapy Protocols, Policies and Procedures. PROVINCIAL DRUG INFORMATION New Provincial Drug Information Specialist We are pleased to announce that Dr. Thanh Vu has recently joined the BC Cancer Agency as a Drug Information Specialist for the Provincial Systemic Therapy Program. Thanh will be working out of the Vancouver Centre Provincial Pharmacy, Room 4250B ; with Drs. Saira Mithani and Mrio de Lemos to provide provincial drug information consultation. Her other responsibilities will include updating and maintaining the BCCA Cancer Drug Manual. Thanh received her Bachelor of Science in Pharmacy and Doctor of Pharmacy from the University of British Columbia. She has previous experience in the oncology setting as a staff pharmacist in oncology at the Prince George Hospital and as a drug use evaluation pharmacist at the Cross Cancer Institute in Edmonton. Her education and experience will be a great addition to the Provincial Drug Information Service. Thanh may be reached Monday to Friday at 604 ; 877-6098 ext 2597. The direct line for Provincial Drug Information is 604 ; 877-6275. LIBRARY CANCER INFORMATION CENTRE Unconventional Cancer Therapies Manual is available on the BC Cancer Agency website bccancer.bc under Patient Public Info, Unconventional Therapies. The manual consists of 46 short monographs on the more commonly used unconventional cancer therapies e.g., Essiac, vitamins, teas, shark cartilage ; and includes tips for the patient and family on how unconventional therapies can be evaluated. For and danazol. 18 NUMBER OF FRACTURES Annual osteoporotic hip fractures per million 1000 Vertebral compression fractures about 90 000 women BONE MASS MEASUREMENT Available BMD units per million: cDXA 1 n 6 ; pDXA 1 n 8 ; For research 2 For routine use 32 The measurement is paid by the patients themselves and is practically not available to the socially disadvantaged patients. Reimbursement 6 $ only for patients with: Hyperparathyroidism Primary hypogonadism After renal transplantation NUMBER OF PATIENTS ON ANTIOSTEOPOROTIC TREATMENT about 2 000 patients in the country. THE PROPORTION OF PATIENTS WITH OSTEOPOROSIS GETTING PHARMACEUTICAL TREATMENT 2, 5 % REIMBURSEMENT OF THE OSTEOPOROTIC TREATMENT 50 % for all patients women and men ; with T-Score 2, 5 AWARENESS: In the general population 27 % Among physicians 53.

Formulae, the positive effects of breast milk are also available for neonates, which are not breastfed. 3. Health and Quality Enhancing Components from Milk Proteins for Food and Pharmaceutical Applications Within the framework of a EU research project FAIR PL96-3077 ; "Caseinophosphopeptides: Nutraceutical Functional Food Ingredients for Food and Pharmaceutical Applications" studies have been started to identify caseinophosphopeptides in the intestinal chyme ileostomy samples, project partner GB ; of human volunteers. For this puropose, a preparative column chromatographic procedure was established which is based on the selective adsorption of phosphopeptides by aluminium oxide. HPLC methods for determination of peptides were optimized. For cell chemical studies of the effect of phosphopeptide preparations in human cell culture model systems Caco-2, HL60, PML ; , different parameters were measured, e.g. membrane damage viability WST-1 assay ; , induction of apoptosis necrosis DNAfragmentation, flow cytometry ; , cytomorphology cell volume diameter ; , epithelial properties monolayer integrity, TEER, activity of brush border enzymes ; of intestinal cells Caco-2. The phosphopeptide preparations, which have been produced up to now project partner IRL ; revealed no cytotoxic effects and hence are suitable for ingredients in functional foods. Effector Properties of Biologically Active Substances Using Cell Culture Model Systems In order to characterize bioactive substances by means of cell culture model systems, particular stress has been laid on the development and establishment of new cytochemical detection systems for components determining the value of milk. Studies on the effects of non-modified and modified ribonucleosides and caseinophosphopeptides CPP ; on different parameters of intestinal cell Caco-2 ; differentiation were carried out. The effect of test compounds on Transepithelial Electrical Resistance TEER ; was determined using a stationary two-compartment system cells were grown on permeable membranes ; . Furthermore, the influence of ribonucleosides and CPP on brush-border associated alkaline phosphatase activity was measured for the first time with a fluorometric assay Fluorophos ; . The modified adenine ribonucleosides N6-dimethyl-adenosine und N6- 2-isopentenyl ; -adenosine, which in preliminary studies were both identified as strongly acting substances in cell culture, prevent 4. proliferating Caco-2 cells from forming an intact monolayer as well as destroy the structure and function of an intact monolayer grown during 10 days of precultivation. The already tested CPP preparations did not provoke any adverse effects. In addition to the above mentioned assays, which are based on stationary conditions, a method for the cultivation of Caco-2 cells under perpetual perfusion of culture medium was established. In the future, this will provide a detection system for transepithelial effects under dynamic conditions. Aiming at the establishment of a cytochemical assay system based on non-cancer cell material, a method for the extraction of polymorphonuclear leukocytes PML ; from the oral cavity was developed. The desired cells are obtained by rinsing with PBS, labeling cells with magnetic CD15-microbeads and subsequent cell sorting in a strong magnetic field MACS ; . This method represents a simple and cost-efficient tool to obtain human cells, which can be used for the cytochemical characterization of bioactive components from milk and food with milk components. 5. Application of Neural Networks in Peptide Chemistry and Food Analysis Artificial neural networks ANN ; were used for the identification and characterization of new bioactive sequences of antihypertensive Angiotensin-IConverting-Enzyme- ACE ; -inhibitory peptides. ANN optimization was achieved using special computer programs to check different network topologies and training parameters. The following model was most suitable for classification and identification of peptide sequences with a relatively high bioactivity: data set for training, verification and testing comprising a total of 30 peptide sequences, topology number and configuration of neurons ; - 64 input 18 hidden layer 2 output, input values per peptide - C-terminal tripeptide sequence 3 21 neurons ; plus hydrophobicity index 1 neuron ; , output neurons binary active inactive ; . After 100 training cycles, this ANN topology resulted in the correct identification of bioactive peptides of the test data set. Analysis of Reaction Kinetics Occurring at Thermal Inactivation of the Milk Enzymes Adenosine Deaminase, Alkaline Phosphatase and -Glutamyl Transferase The pasteurizing steps for high-temperature and short time pasteurization of liquid milk for consumption as determined in the German Milk Ordinance are characterized by the inactivation of the milk enzymes alkaline phosphatase ALP, EC 3.1.3.1 ; and lactoperoxidase POD, EC 1.11.1.7 ; . The present study did not only deal with the aforementioned enzymes, but also with the thermal stability of glutamyl transferase -GT, EC 2.3.2.2 ; and adenosine deaminase ADA, EC 3.5.4.4 ; . Except from POD, the inactivation kinetics of the enzymes ALP, -GT and 6. 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Comment: I also found myself wondering how docs would resist the blandishments of drug reps and the pressures of direct-toconsumer advertising. Patients even now come with all sorts of demands derived from ads, sometimes with extremely strong convictions. Why wouldn't such patients seek the docs who have the most expensive practice profiles, assuming they're more likely to get what they want, and not have "good care" "rationed"? It would cost them nothing, since anything the PCP orders is fully covered. It seems to me that the path of least resistance would be to order what the patient wants, and that a conscientious doc would be constantly arguing with patients over coverage decisions. Reply: The risk-rating aspect of Doctor Managed Care was revised in response to this and other similar comments of experts. ; The health promotion compassionate care fund for each PCP's patients and the PCP's income, are both inversely related to the sickness care spending for the PCP's group of patients. Consequently, as described in the "Cost Control" section of Doctor Managed Care, each PCP and his her patients all benefit if sickness costs are controlled by providing insurance funding only for evidence-based tests and treatments. When a patient asks his her PCP for a prescription for a 0 per month highly advertised brand name drug when a per month generic is medically equivalent, the PCP could give the patient the choice of having the generic for free or paying for the brand name drug. There would still be discussions and occasional arguments about coverage decisions. Most patients would probably seek the doctors with the least expensive practice profiles because they would receive more in health promotion compassionate care benefits. Comment: Asking docs to make all judgments regarding indemnity payments for living needs for all of the disabled and all work-related injuries seems to add another monumental task. It seems like the docs have to become insurance executives and actuaries on top of everything else. 458.
Table 1. The Viscosities of Neutralized 0.5% Aqueous Dispersions of Carbomer.
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The aim of the systematic review, however, was to determine whether pde-5 inhibitors such as sildenafil viagra ; , vardenafil levitra ; and tadalafil cialis ; are also a safe and effective option for men with diabetes. Synopsis The latest GP Bulletin is now available on the Dept of Health website. Main articles include: Feedback from consultation on patient choice in primary care Help available for PCTs to implement new GMS contract `Considerable progress' in contract implementation PCT out-of-hours services extra funding Wider range of services in primary care to be encouraged Specialist care in respiratory disease NHS learning from international organizations.
Personal practice indian pediatrics 2002; 9-266 atypical pneumonia in children manju salaria meenu singh from the advanced pediatric center, post graduate institute of medical sciences and research, chandigarh 160 012, india. Reversibility of the effects Reversibility of the effects was not considered to provide a strong argument for reducing the concern of D4. If exposure is continuous also the effect would be constant. However, one expert had a higher concern for irreversible effects such as malformations if the fetus is exposed during pregnancy. Classification according to the criteria All SE expressed concern that the mechanism by which D4 exerted its effect on the LH surge had not been shown and that the conclusion made by IND that the reproductive effects seen were not relevant to humans was based on an unproven hypothesis. In addition, as indicated in the above summary of the discussions, most SE had several doubts about the proposed mechanism, since it did not seem to fit with the data and predictions based on present knowledge. However, a few experts thought that the proposed mechanism could be plausible, especially when the considerable species difference in the regulation of ovulation in rats and humans, was taken into account. Some SE expressed that the relevance of the effects for humans may not be excluded even if the suggested mechanism involving decreased activity of the noradrenergic neurons in the brain, had been shown. For several experts, consideration of the dose was important when discussing the category although it was recognised that the criteria did not consider dose, more than in the concept of "limit dose". However, although one expert considered 300 ppm as a high dose, others did not consider 300 ppm LOAEL ; or 70 ppm NOEL ; as exceptionally high doses of a volatile compound. A few experts thought that the evidence were not strong enough to motivate a change in the present classification of category 3. Most other experts argued on the other hand that further data were required, such as data showing the mechanism leading to a blocked LH surge and further evidence demonstrating why this mechanism should not to be relevant to humans, in order to classify in category 3 rather than category 2 since clear reproductive effects had been demonstrated. It had also been shown that D4 reduces prolactin and does interfere with the dopamine receptor. After this discussion the Specialised Experts jointly drafted and adopted the following conclusions.

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